The Effect Of Hyaluronic Acid And Melatonin With Systemic Administration of Vitamin C On Implant Stability After Immediate Implant in Anterior Region
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT03804177|
Recruitment Status : Not yet recruiting
First Posted : January 15, 2019
Last Update Posted : January 16, 2019
The concept of immediate implant placement at the time of tooth extraction was first introduced by Schulte et al. on animal studies. Since then, many follow‑up studies examining different variables have supported the concept of immediate implant placement. pioneered a major contribution to immediate implant placement in human studies which recommended the insertion of an implant into a fresh extraction socket.
They advocated immediate implant placement primarily to reduce the number of surgical interventions needed to perform an implant‑supported rehabilitation and shorten the treatment time.
Placement of implants immediately into extraction sites allow the surgeon to idealize the position of the implant appropriately with a better rehabilitation of the normal contour to the facial aspect of the final restoration.
Immediate implant placement in fresh extraction sockets was reported to reduce alveolar bone resorption. Better esthetic outcomes were achieved including the prosthetic crown length in harmony with the adjacent teeth, natural scalloping and easier distinct papillae to achieve and maximum soft tissue support.
Hyaluronic acid is a glycosaminoglycan, this unique molecule is implicated In a variety of biological functions including structural integrity, and the regulation of embryologic development. It is described as a natural organic substance, with physiological therapy activity, main component of the extracellular matrix of many tissues such as the skin, synovial joints and periodontal tissues .
|Condition or disease||Intervention/treatment||Phase|
|Immediate Dental Implant||Procedure: immediate implant placement with melatonin hyaluronic acid vit C Procedure: immediate implant placement without melatonin hyaluronic acid vit C||Phase 4|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||24 participants|
|Intervention Model:||Parallel Assignment|
|Intervention Model Description:||it is randomized clinical trial|
|Masking:||Double (Participant, Outcomes Assessor)|
|Masking Description:||single blinded|
|Official Title:||The Effect Of Hyaluronic Acid And Melatonin With Systemic Administration of Vitamin C On Implant Stability After Immediate Implant Placement in Anterior and Premolar Region in Systemically Healthy Patients|
|Estimated Study Start Date :||February 10, 2019|
|Estimated Primary Completion Date :||February 10, 2022|
|Estimated Study Completion Date :||April 30, 2022|
Experimental: implant with hyaluronic melatonin vit c
implant placement with topical application of hyaluronic and melatonin and systemic administration of vitamin C
Procedure: immediate implant placement with melatonin hyaluronic acid vit C
immediate implant placement with melatonin and hyaluronic acid and systemic administration vitamin C
Other Name: early implant placement
Active Comparator: immediate implant
immediate implant placement alone without melatonin or hyauronic acid nor vitamin c
Procedure: immediate implant placement without melatonin hyaluronic acid vit C
immediate implant placement without melatonin and hyaluronic acid and systemic administration vitamin C
Other Name: early implant placement
- implant stability [ Time Frame: 6 months ]implant stability by ostell
- soft tissue healing [ Time Frame: 6 months ]soft tissue healing by likert scale (0 indicate complete soft tissue Closure (no line of fibrin) , 1 indicate complete closure (thin line of fibrin) , 2 indcate complete closure (fibrin) , 3 indicate in complete closure (dehiscence ) , 4 indicate incomplete closure (necrosis)
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03804177
|Contact: ahmed Nasser, Mscfirstname.lastname@example.org|
|Study Chair:||Mona darhous, PHD||Cairo University|
|Study Chair:||Mona shoieb, PHD||Cairo University|