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Association Between IVUS and OCT Parameters and Invasive Physiologic Indices

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ClinicalTrials.gov Identifier: NCT03795714
Recruitment Status : Recruiting
First Posted : January 8, 2019
Last Update Posted : January 21, 2019
Sponsor:
Collaborator:
Samsung Medical Center
Information provided by (Responsible Party):
Bon-Kwon Koo, Seoul National University Hospital

Brief Summary:
  1. to evaluate diagnostic accuracy and performance of IVUS and OCT-derived quantitative parameters to predict functional significance of stenosis defined using all the available physiologic indices.
  2. to explores the association between intravascular imaging-derived plaque characteristics and invasive physiologic indices.

Condition or disease Intervention/treatment
Ischemic Heart Disease Diagnostic Test: IVUS or OCT and Invasive physiologic indices

Detailed Description:

Given the inherent limitations of coronary angiography to depict the presence of functionally significant epicardial coronary stenosis and discrepancy between angiographic stenosis severity and the presence of myocardial ischemia, invasive physiologic indices such as fractional flow reserve (FFR) or instantaneous wave-free ratio (iFR) has been a standard method to guide decision of revascularization.

Intravascular ultrasound (IVUS) and optical coherence tomography (OCT) are an intracoronary imaging method able to provide information about lumen area, vessel area, plaque burden, and plaque characteristics that can be used for the guidance of revascularization procedure. Several previous studies explored the diagnostic performance of intravascular imaging-defined quantitative parameters to predict functional significance defined by FFR, however, quantitative parameter derived from intravascular imaging showed only moderate diagnostic accuracy and the optimal cut-off value of intravascular imaging-derived minimal lumen area (MLA) or minimal lumen diameter (MLD) were varied according to the patient population, interrogated vessels, and the location of target lesions, suggesting limited clinical relevance of judging functional significance of target stenosis using intravascular imaging alone. Nevertheless, the adoption rate of FFR-guided decision has been limited due to various reasons and intravascular image-guided decision has been still used in substantial proportion of the patients.

Recently, new resting pressure-derived indices including resting full-cycle ratio (RFR) or diastolic pressure ratio (dPR) have been introduced as other substitutes for iFR, which does not require administration of hyperemic agents, therefore, possess more convenient in daily practice. Recent study with the largest sample size demonstrated identical diagnostic property and prognostic implication among iFR, RFR, and dPR. As those resting pressure-derived indices might have more generalizability for daily practice, it is expected to raise the adoption rate of physiologic interrogation. Therefore, understanding the association between all the available physiologic indices and intravascular imaging-derived quantitative and qualitative parameters might be important in clinical decision for patient who underwent invasive coronary angiography.

In this regard, the investigators sought to evaluate diagnostic accuracy and performance of intravascular imaging-derived quantitative parameters to predict functional significance of stenosis defined using all the available physiologic indices and further explores the association between IVUS and OCT-derived plaque characteristics and invasive physiologic indices.


Layout table for study information
Study Type : Observational
Estimated Enrollment : 166 participants
Observational Model: Case-Only
Time Perspective: Retrospective
Official Title: Intravascular Ultrasound and Optical Coherence Tomography-Defined Optimal Criteria and Plaque Characteristics for Defining the Functional Significance of Coronary Stenoses Using Resting and Hyperemic Physiologic Indices
Actual Study Start Date : November 17, 2017
Estimated Primary Completion Date : January 31, 2019
Estimated Study Completion Date : March 31, 2019

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Heart Diseases

Group/Cohort Intervention/treatment
Intravascular Imaging and Physiologic Assessment
330 patients with suspected ischemic heart disease and who underwent IVUS or OCT assessment and invasive physiologic assessment.
Diagnostic Test: IVUS or OCT and Invasive physiologic indices
IVUS or OCT measurement in order to evaluate the lesion morphology and stent optimization, and invasive physiologic measurement in order to functional significance of epicardial stenosis




Primary Outcome Measures :
  1. Diagnostic accuracy of percent diameter stenosis assessed by intravascular imaging to predict functional significance assessed by fractional flow reserve (FFR) [ Time Frame: During Cardiac Cath ]
    Diagnostic accuracy of percent diameter stenosis assessed by intravascular imaging to predict functional significance defined by FFR ≤0.80

  2. Diagnostic accuracy of percent diameter stenosis assessed by intravascular imaging to predict functional significance assessed by instantaneous wave-free ratio (iFR) [ Time Frame: During Cardiac Cath ]
    Diagnostic accuracy of percent diameter stenosis assessed by intravascular imaging to predict functional significance defined by iFR ≤0.89

  3. Diagnostic accuracy of percent diameter stenosis assessed by intravascular imaging to predict functional significance assessed by diastolic pressure ratio (dPR) [ Time Frame: During Cardiac Cath ]
    Diagnostic accuracy of percent diameter stenosis assessed by intravascular imaging to predict functional significance defined by dPR ≤0.89

  4. Diagnostic accuracy of percent diameter stenosis assessed by intravascular imaging to predict functional significance assessed by resting full-cycle ratio (RFR) [ Time Frame: During Cardiac Cath ]
    Diagnostic accuracy of percent diameter stenosis assessed by intravascular imaging to predict functional significance defined by RFR ≤0.89

  5. Diagnostic accuracy of minimal lumen diameter assessed by intravascular imaging to predict functional significance assessed by FFR [ Time Frame: During Cardiac Cath ]
    Diagnostic accuracy of minimal lumen diameter assessed by intravascular imaging to predict functional significance defined by FFR ≤0.80

  6. Diagnostic accuracy of minimal lumen diameter assessed by intravascular imaging to predict functional significance assessed by iFR [ Time Frame: During Cardiac Cath ]
    Diagnostic accuracy of minimal lumen diameter assessed by intravascular imaging to predict functional significance defined by iFR ≤0.89

  7. Diagnostic accuracy of minimal lumen diameter assessed by intravascular imaging to predict functional significance assessed by dPR [ Time Frame: During Cardiac Cath ]
    Diagnostic accuracy of minimal lumen diameter assessed by intravascular imaging to predict functional significance defined by dPR ≤0.89

  8. Diagnostic accuracy of minimal lumen diameter assessed by intravascular imaging to predict functional significance assessed by RFR [ Time Frame: During Cardiac Cath ]
    Diagnostic accuracy of minimal lumen diameter assessed by intravascular imaging to predict functional significance defined by RFR ≤0.89

  9. Diagnostic accuracy of minimal lumen area assessed by intravascular imaging to predict functional significance assessed by FFR [ Time Frame: During Cardiac Cath ]
    Diagnostic accuracy of minimal lumen area assessed by intravascular imaging to predict functional significance defined by FFR ≤0.80

  10. Diagnostic accuracy of minimal lumen area assessed by intravascular imaging to predict functional significance assessed by iFR [ Time Frame: During Cardiac Cath ]
    Diagnostic accuracy of minimal lumen area assessed by intravascular imaging to predict functional significance defined by iFR ≤0.89

  11. Diagnostic accuracy of minimal lumen area assessed by intravascular imaging to predict functional significance assessed by dPR [ Time Frame: During Cardiac Cath ]
    Diagnostic accuracy of minimal lumen area assessed by intravascular imaging to predict functional significance defined by dPR ≤0.89

  12. Diagnostic accuracy of minimal lumen area assessed by intravascular imaging to predict functional significance assessed by RFR [ Time Frame: During Cardiac Cath ]
    Diagnostic accuracy of minimal lumen area assessed by intravascular imaging to predict functional significance defined by RFR ≤0.89

  13. Diagnostic accuracy of plaque burden assessed by intravascular imaging to predict functional significance assessed by FFR [ Time Frame: During Cardiac Cath ]
    Diagnostic accuracy of plaque burden assessed by intravascular imaging to predict functional significance defined by FFR ≤0.80

  14. Diagnostic accuracy of plaque burden assessed by IVUS to predict functional significance assessed by iFR [ Time Frame: During Cardiac Cath ]
    Diagnostic accuracy of plaque burden assessed by IVUS to predict functional significance defined by iFR ≤0.89

  15. Diagnostic accuracy of plaque burden assessed by IVUS to predict functional significance assessed by dPR [ Time Frame: During Cardiac Cath ]
    Diagnostic accuracy of plaque burden assessed by IVUS to predict functional significance defined by dPR ≤0.89

  16. Diagnostic accuracy of plaque burden assessed by intravascular imaging to predict functional significance assessed by RFR [ Time Frame: During Cardiac Cath ]
    Diagnostic accuracy of plaque burden assessed by intravascular imaging to predict functional significance defined by RFR ≤0.89


Secondary Outcome Measures :
  1. Sensitivity of percent diameter stenosis assessed by intravascular imaging to predict functional significance assessed by FFR [ Time Frame: During Cardiac Cath ]
    Sensitivity of percent diameter stenosis assessed by intravascular imaging to predict functional significance defined by FFR ≤0.80

  2. Sensitivity of percent diameter stenosis assessed by intravascular imaging to predict functional significance assessed by iFR [ Time Frame: During Cardiac Cath ]
    Sensitivity of percent diameter stenosis assessed by intravascular imaging to predict functional significance defined by iFR ≤0.89

  3. Sensitivity of percent diameter stenosis assessed by intravascular imaging to predict functional significance assessed by dPR [ Time Frame: During Cardiac Cath ]
    Sensitivity of percent diameter stenosis assessed by intravascular imaging to predict functional significance defined by dPR ≤0.89

  4. Sensitivity of percent diameter stenosis assessed by intravascular imaging to predict functional significance assessed by RFR [ Time Frame: During Cardiac Cath ]
    Sensitivity of percent diameter stenosis assessed by intravascular imaging to predict functional significance defined by RFR ≤0.89

  5. Sensitivity of minimal lumen diameter assessed by intravascular imaging to predict functional significance assessed by FFR [ Time Frame: During Cardiac Cath ]
    Sensitivity of minimal lumen diameter assessed by intravascular imaging to predict functional significance defined by FFR ≤0.80

  6. Sensitivity of minimal lumen diameter assessed by intravascular imaging to predict functional significance assessed by iFR [ Time Frame: During Cardiac Cath ]
    Sensitivity of minimal lumen diameter assessed by intravascular imaging to predict functional significance defined by iFR ≤0.89

  7. Sensitivity of minimal lumen diameter assessed by intravascular imaging to predict functional significance assessed by dPR [ Time Frame: During Cardiac Cath ]
    Sensitivity of minimal lumen diameter assessed by intravascular imaging to predict functional significance defined by dPR ≤0.89

  8. Sensitivity of minimal lumen diameter assessed by intravascular imaging to predict functional significance assessed by RFR [ Time Frame: During Cardiac Cath ]
    Sensitivity of minimal lumen diameter assessed by intravascular imaging to predict functional significance defined by RFR ≤0.89

  9. Sensitivity of minimal lumen area assessed by intravascular imaging to predict functional significance assessed by FFR [ Time Frame: During Cardiac Cath ]
    Sensitivity of minimal lumen area assessed by intravascular imaging to predict functional significance defined by FFR ≤0.80

  10. Sensitivity of minimal lumen area assessed by intravascular imaging to predict functional significance assessed by iFR [ Time Frame: During Cardiac Cath ]
    Sensitivity of minimal lumen area assessed by intravascular imaging to predict functional significance defined by iFR ≤0.89

  11. Sensitivity of minimal lumen area assessed by intravascular imaging to predict functional significance assessed by dPR [ Time Frame: During Cardiac Cath ]
    Sensitivity of minimal lumen area assessed by intravascular imaging to predict functional significance defined by dPR ≤0.89

  12. Sensitivity of minimal lumen area assessed by intravascular imaging to predict functional significance assessed by RFR [ Time Frame: During Cardiac Cath ]
    Sensitivity of minimal lumen area assessed by intravascular imaging to predict functional significance defined by RFR ≤0.89

  13. Sensitivity of plaque burden assessed by intravascular imaging to predict functional significance assessed by FFR [ Time Frame: During Cardiac Cath ]
    Sensitivity of plaque burden assessed by intravascular imaging to predict functional significance defined by FFR ≤0.80

  14. Sensitivity of plaque burden assessed by intravascular imaging to predict functional significance assessed by iFR [ Time Frame: During Cardiac Cath ]
    Sensitivity of plaque burden assessed by intravascular imaging to predict functional significance defined by iFR ≤0.89

  15. Sensitivity of plaque burden assessed by intravascular imaging to predict functional significance assessed by dPR [ Time Frame: During Cardiac Cath ]
    Sensitivity of plaque burden assessed by intravascular imaging to predict functional significance defined by dPR ≤0.89

  16. Sensitivity of plaque burden assessed by intravascular imaging to predict functional significance assessed by RFR [ Time Frame: During Cardiac Cath ]
    Sensitivity of minimal lumen area assessed by intravascular imaging to predict functional significance defined by RFR ≤0.89

  17. Specificity of percent diameter stenosis assessed by intravascular imaging to predict functional significance assessed by FFR [ Time Frame: During Cardiac Cath ]
    Specificity of percent diameter stenosis assessed by intravascular imaging to predict functional significance defined by FFR ≤0.80

  18. Specificity of percent diameter stenosis assessed by intravascular imaging to predict functional significance assessed by iFR [ Time Frame: During Cardiac Cath ]
    Specificity of percent diameter stenosis assessed by intravascular imaging to predict functional significance defined by iFR ≤0.89

  19. Specificity of percent diameter stenosis assessed by intravascular imaging to predict functional significance assessed by dPR [ Time Frame: During Cardiac Cath ]
    Specificity of percent diameter stenosis assessed by intravascular imaging to predict functional significance defined by dPR ≤0.89

  20. Specificity of percent diameter stenosis assessed by intravascular imaging to predict functional significance assessed by RFR [ Time Frame: During Cardiac Cath ]
    Specificity of percent diameter stenosis assessed by intravascular imaging to predict functional significance defined by RFR ≤0.89

  21. Specificity of minimal lumen diameter assessed by intravascular imaging to predict functional significance assessed by FFR [ Time Frame: During Cardiac Cath ]
    Specificity of minimal lumen diameter assessed by intravascular imaging to predict functional significance defined by FFR ≤0.80

  22. Specificity of minimal lumen diameter assessed by intravascular imaging to predict functional significance assessed by iFR [ Time Frame: During Cardiac Cath ]
    Specificity of minimal lumen diameter assessed by intravascular imaging to predict functional significance defined by iFR ≤0.89

  23. Specificity of minimal lumen diameter assessed by intravascular imaging to predict functional significance assessed by dPR [ Time Frame: During Cardiac Cath ]
    Specificity of minimal lumen diameter assessed by intravascular imaging to predict functional significance defined by dPR ≤0.89

  24. Specificity of minimal lumen diameter assessed by intravascular imaging to predict functional significance assessed by RFR [ Time Frame: During Cardiac Cath ]
    Specificity of minimal lumen diameter assessed by intravascular imaging to predict functional significance defined by RFR ≤0.89

  25. Specificity of minimal lumen area assessed by intravascular imaging to predict functional significance assessed by FFR [ Time Frame: During Cardiac Cath ]
    Specificity of minimal lumen area assessed by intravascular imaging to predict functional significance defined by FFR ≤0.80

  26. Specificity of minimal lumen area assessed by intravascular imaging to predict functional significance assessed by iFR [ Time Frame: During Cardiac Cath ]
    Specificity of minimal lumen area assessed by intravascular imaging to predict functional significance defined by iFR ≤0.89

  27. Specificity of minimal lumen area assessed by intravascular imaging to predict functional significance assessed by dPR [ Time Frame: During Cardiac Cath ]
    Specificity of minimal lumen area assessed by intravascular imaging to predict functional significance defined by dPR ≤0.89

  28. Specificity of minimal lumen area assessed by intravascular imaging to predict functional significance assessed by RFR [ Time Frame: During Cardiac Cath ]
    Specificity of minimal lumen area assessed by intravascular imaging to predict functional significance defined by RFR ≤0.89

  29. Specificity of plaque burden assessed by intravascular imaging to predict functional significance assessed by FFR [ Time Frame: During Cardiac Cath ]
    Specificity of plaque burden assessed by intravascular imaging to predict functional significance defined by FFR ≤0.80

  30. Specificity of plaque burden assessed by intravascular imaging to predict functional significance assessed by iFR [ Time Frame: During Cardiac Cath ]
    Specificity of plaque burden assessed by intravascular imaging to predict functional significance defined by iFR ≤0.89

  31. Specificity of plaque burden assessed by intravascular imaging to predict functional significance assessed by dPR [ Time Frame: During Cardiac Cath ]
    Specificity of plaque burden assessed by intravascular imaging to predict functional significance defined by dPR ≤0.89

  32. Specificity of plaque burden assessed by intravascular imaging to predict functional significance assessed by RFR [ Time Frame: During Cardiac Cath ]
    Specificity of plaque burden assessed by intravascular imaging to predict functional significance defined by RFR ≤0.89

  33. Linear correlation between percent diameter stenosis and FFR [ Time Frame: During Cardiac Cath ]
    Linear regression analysis between percent diameter stenosis and FFR

  34. Linear correlation between percent diameter stenosis and iFR [ Time Frame: During Cardiac Cath ]
    Linear regression analysis between percent diameter stenosis and iFR

  35. Linear correlation between percent diameter stenosis and dPR [ Time Frame: During Cardiac Cath ]
    Linear regression analysis between percent diameter stenosis and dPR

  36. Linear correlation between percent diameter stenosis and RFR [ Time Frame: During Cardiac Cath ]
    Linear regression analysis between percent diameter stenosis and RFR

  37. Linear correlation between minimal lumen diameter and FFR [ Time Frame: During Cardiac Cath ]
    Linear regression analysis between minimal lumen diameter and FFR

  38. Linear correlation between minimal lumen diameter and iFR [ Time Frame: During Cardiac Cath ]
    Linear regression analysis between minimal lumen diameter and iFR

  39. Linear correlation between minimal lumen diameter and dPR [ Time Frame: During Cardiac Cath ]
    Linear regression analysis between minimal lumen diameter and dPR

  40. Linear correlation between minimal lumen diameter and RFR [ Time Frame: During Cardiac Cath ]
    Linear regression analysis between minimal lumen diameter and RFR

  41. Linear correlation between minimal lumen area and FFR [ Time Frame: During Cardiac Cath ]
    Linear regression analysis between minimal lumen area and FFR

  42. Linear correlation between minimal lumen area and iFR [ Time Frame: During Cardiac Cath ]
    Linear regression analysis between minimal lumen area and iFR

  43. Linear correlation between minimal lumen area and dPR [ Time Frame: During Cardiac Cath ]
    Linear regression analysis between minimal lumen area and dPR

  44. Linear correlation between minimal lumen area and RFR [ Time Frame: During Cardiac Cath ]
    Linear regression analysis between minimal lumen area and RFR

  45. Linear correlation between plaque burden and FFR [ Time Frame: During Cardiac Cath ]
    Linear regression analysis between plaque burden and FFR

  46. Linear correlation between plaque burden and iFR [ Time Frame: During Cardiac Cath ]
    Linear regression analysis between plaque burden and iFR

  47. Linear correlation between plaque burden and dPR [ Time Frame: During Cardiac Cath ]
    Linear regression analysis between plaque burden and dPR

  48. Linear correlation between plaque burden and RFR [ Time Frame: During Cardiac Cath ]
    Linear regression analysis between plaque burden and RFR

  49. Discriminatory function of percent diameter stenosis to predict functional significance assessed by FFR [ Time Frame: During Cardiac Cath ]
    Discriminatory function of percent diameter stenosis to predict functional significance defined by FFR≤0.80

  50. Discriminatory function of percent diameter stenosis to predict functional significance assessed by iFR [ Time Frame: During Cardiac Cath ]
    Discriminatory function of percent diameter stenosis to predict functional significance defined by iFR≤0.89

  51. Discriminatory function of percent diameter stenosis to predict functional significance assessed by dPR [ Time Frame: During Cardiac Cath ]
    Discriminatory function of percent diameter stenosis to predict functional significance defined by dPR≤0.89

  52. Discriminatory function of percent diameter stenosis to predict functional significance assessed by RFR [ Time Frame: During Cardiac Cath ]
    Discriminatory function of percent diameter stenosis to predict functional significance defined by RFR≤0.89

  53. Discriminatory function of minimal lumen diameter to predict functional significance assessed by FFR [ Time Frame: During Cardiac Cath ]
    Discriminatory function of minimal lumen diameter to predict functional significance defined by FFR≤0.80

  54. Discriminatory function of minimal lumen diameter to predict functional significance assessed by iFR [ Time Frame: During Cardiac Cath ]
    Discriminatory function of minimal lumen diameter to predict functional significance defined by iFR≤0.89

  55. Discriminatory function of minimal lumen diameter to predict functional significance assessed by dPR [ Time Frame: During Cardiac Cath ]
    Discriminatory function of minimal lumen diameter to predict functional significance defined by dPR≤0.89

  56. Discriminatory function of minimal lumen diameter to predict functional significance assessed by RFR [ Time Frame: During Cardiac Cath ]
    Discriminatory function of minimal lumen diameter to predict functional significance defined by RFR≤0.89

  57. Discriminatory function of minimal lumen area to predict functional significance assessed by FFR [ Time Frame: During Cardiac Cath ]
    Discriminatory function of minimal lumen area to predict functional significance defined by FFR≤0.80

  58. Discriminatory function of minimal lumen area to predict functional significance assessed by iFR [ Time Frame: During Cardiac Cath ]
    Discriminatory function of minimal lumen area to predict functional significance defined by iFR≤0.89

  59. Discriminatory function of minimal lumen area to predict functional significance assessed by dPR [ Time Frame: During Cardiac Cath ]
    Discriminatory function of minimal lumen area to predict functional significance defined by dPR≤0.89

  60. Discriminatory function of minimal lumen area to predict functional significance assessed by RFR [ Time Frame: During Cardiac Cath ]
    Discriminatory function of minimal lumen area to predict functional significance defined by RFR≤0.89

  61. Discriminatory function of plaque burden to predict functional significance assessed by FFR [ Time Frame: During Cardiac Cath ]
    Discriminatory function of plaque burden to predict functional significance defined by FFR≤0.80

  62. Discriminatory function of plaque burden to predict functional significance assessed by iFR [ Time Frame: During Cardiac Cath ]
    Discriminatory function of plaque burden to predict functional significance defined by iFR≤0.89

  63. Discriminatory function of plaque burden to predict functional significance assessed by dPR [ Time Frame: During Cardiac Cath ]
    Discriminatory function of plaque burden to predict functional significance defined by dPR≤0.89

  64. Discriminatory function of plaque burden to predict functional significance assessed by RFR [ Time Frame: During Cardiac Cath ]
    Discriminatory function of plaque burden to predict functional significance defined by RFR≤0.89



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Layout table for eligibility information
Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
330 patients with suspected ischemic heart disease and who underwent IVUS or OCT assessment and invasive physiologic assessment.
Criteria

Inclusion Criteria:

  • Patients who suspected ischemic heart disease, and underwent invasive physiologic assessment and intravascular ultrasound

Exclusion Criteria:

  • Cardiogenic shock
  • Graft vessel
  • In-stent restenosis

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03795714


Contacts
Layout table for location contacts
Contact: Joo Myung Lee, MD, MPH, PhD 82-10-8884-8439 drone80@hanmail.net
Contact: Ki Hong Choi, MD 82-10-8875-1648 cardiokh@gmail.com

Locations
Layout table for location information
Korea, Republic of
Samsung Medical Center Recruiting
Seoul, Korea, Republic of, 06351
Contact: Joo Myung Lee, MD, MPH, PhD       drone80@hanmail.net   
Contact: Ki Hong Choi, MD       cardiokh@gmail.com   
Principal Investigator: Joo Myung Lee, MD, MPH, PhD         
Sub-Investigator: Ki Hong Choi, MD         
Seoul national university hospital Recruiting
Seoul, Korea, Republic of, 110-744
Contact: Bon-kown Koo, MD/PhD    82-2-2072-2062    bkkoo@snu.ac.kr   
Principal Investigator: Bon-kwon Koo, MD/PhD         
Sponsors and Collaborators
Seoul National University Hospital
Samsung Medical Center
Investigators
Layout table for investigator information
Study Chair: Bon-Kwon Koo, MD, PhD Professor
Principal Investigator: Joo Myung Lee, MD, MPH, PhD Assistant Professor

Layout table for additonal information
Responsible Party: Bon-Kwon Koo, Professor, Seoul National University Hospital
ClinicalTrials.gov Identifier: NCT03795714     History of Changes
Other Study ID Numbers: IVUS2017-11-056-001
First Posted: January 8, 2019    Key Record Dates
Last Update Posted: January 21, 2019
Last Verified: January 2019

Layout table for additional information
Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No

Keywords provided by Bon-Kwon Koo, Seoul National University Hospital:
Intravascular Ultrasound
Optical Coherence Tomography
Fractional Flow Reserve
Diastolic Pressure Ratio
Resting Full-Cycle Ratio
Ischemic Heart Disease
Instantaneous Wave-free Ratio

Additional relevant MeSH terms:
Layout table for MeSH terms
Heart Diseases
Myocardial Ischemia
Coronary Artery Disease
Cardiovascular Diseases
Vascular Diseases
Coronary Disease
Arteriosclerosis
Arterial Occlusive Diseases