Prevalence of Primary Aldosteronism in Patients With Stroke
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|ClinicalTrials.gov Identifier: NCT03789357|
Recruitment Status : Active, not recruiting
First Posted : December 28, 2018
Last Update Posted : March 3, 2021
Strokes leads to significant morbidity and mortality, and hypertension is the most important risk factor for strokes. It is estimated that up to 10% of patients with hypertension have the underlying, treatable condition of primary aldosteronism. Hence, we hypothesize that the prevalence of primary aldosteronism is high in patients with strokes, a complication of long-standing hypertension.
Patients admitted with an acute stroke to the Acute Stroke Unit, Changi General Hospital, will be screened for Primary Aldosteronism three months post-stroke, and confirmatory tests will be done with saline-infusion test.
|Condition or disease||Intervention/treatment|
|Primary Aldosteronism Stroke||Diagnostic Test: Aldosterone renin ratio|
|Study Type :||Observational|
|Estimated Enrollment :||300 participants|
|Official Title:||Prevalence of Primary Aldosteronism in Patients With Stroke|
|Actual Study Start Date :||May 1, 2018|
|Estimated Primary Completion Date :||July 31, 2021|
|Estimated Study Completion Date :||June 30, 2022|
All patients admitted to the Acute Stroke Unit
Diagnostic Test: Aldosterone renin ratio
Aldosterone Renin Ratio to screen for Primary Aldosteronism
- Percentage of patients with stroke with confirmed primary aldosteronism in patients admitted to the acute stroke unit for stroke [ Time Frame: 6 months ]Percentage of patients with confirmed Primary Aldosteronism using confirmatory test
- Accuracy of Screening test in early period post-stroke [ Time Frame: 3 months ]To determine if the screening blood test for primary aldosteronism performed within 1 week post-stroke is equally accurate compared to being performed 2-4 months post-stroke.
- Percentage of unilateral primary aldosteronism in patients admitted with acute stroke [ Time Frame: 6 months ]Percentage of unilateral PA amongst patients with stroke
- Percentage of patients with positive screening test in patients admitted with acute stroke [ Time Frame: 3 months ]
- Blood pressure change after treatment for primary aldosteronism [ Time Frame: 12 months ]
- Cardiac Complications [ Time Frame: 6 months ]Cardiac complications in patients with primary aldosteronism, compared to those without primary aldosteronism, as assessed by transthoracic echocardiography features of left ventricular hypertrophy / mass, and diastolic dysfunction
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Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03789357
|Changi General Hospital|
|Singapore, Singapore, 529889|
|Principal Investigator:||Troy Puar, MRCP UK||Changi General Hospital|