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Trial record 46 of 181 for:    Recruiting, Not yet recruiting, Available Studies | Chest pain

Epicardial Adipose Tissue Thickness PredIcts Obstructive Coronary Artery Disease in Acute Coronary Syndrome Patients (EPIC-ACS)

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ClinicalTrials.gov Identifier: NCT03787797
Recruitment Status : Recruiting
First Posted : December 25, 2018
Last Update Posted : December 27, 2018
Sponsor:
Information provided by (Responsible Party):
Amir Abbas Mahabadi, University Hospital, Essen

Brief Summary:
Epicardial adipose tissue (EAT) is a visceral adipose tissue that surrounds the heart and the coronary arteries. It is metabolically active, secreting pro- and anti-inflammatory mediators and cytokines. With increasing EAT volume, inflammatory activity increasing, which suggests that EAT may locally influence atherosclerosis development in the coronary artery tree. The amount of EAT is associated with cardiovascular disease risk factors as well as presence and progression of subclinical atherosclerosis. Likewise, EAT volume is increased in patient with prevalent and incident coronary artery disease manifestation. In the setting of acute coronary syndrome, EAT was found to be associated with the TIMI risk score and Syntax II score. While CT imaging of the heart is the gold standard for EAT quantification, transthoracic echocardiography allows for a quick and reliable assessment of EAT thickness, as has been used in research studies and may qualify for routine EAT assessment in clinical routine.However, currently data on how quantification of EAT in clinical routine may impact patient management is lacking. We aim to investigate, whether quantification of EAT thickness via transthoracic echocardiography enables improved risk stratification in patients presenting with acute chest pain to the emergency department.

Condition or disease Intervention/treatment
Acute Coronary Syndrome Diagnostic Test: Echocardiography

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Study Type : Observational
Estimated Enrollment : 653 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Epicardial Adipose Tissue Thickness PredIcts Obstructive Coronary Artery Disease in Acute Coronary Syndrome Patients
Actual Study Start Date : December 6, 2018
Estimated Primary Completion Date : October 1, 2019
Estimated Study Completion Date : December 30, 2019

Resource links provided by the National Library of Medicine



Intervention Details:
  • Diagnostic Test: Echocardiography
    Assessment of epicardial adipose tissue thickness


Primary Outcome Measures :
  1. Coronary revascularization [ Time Frame: within 90 days after initial presentation ]
    Number of Participants with need for coronary revascularization therapy


Secondary Outcome Measures :
  1. Invasive coronary angiography [ Time Frame: within 90 days after initial presentation ]
    Number of Participants undergoing invasive coronary angiography



Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Inclusion of patients without known coronary artery disease undergoing workup for suspected acute coronary syndrome at the emergency department of the University Hospital Essen.
Criteria

Inclusion Criteria:

  • admission to the emergency department of the University Hospital Essen with acute chest pain suggestive of an acute coronary syndrome

Exclusion Criteria:

  • Known obstructive coronary artery disease prior to presentation, prior revascularization therapy, unwillingness to provide informed consent

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03787797


Contacts
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Contact: Amir A Mahabadi, MD +49201723 ext 84822 amir-abbas.mahabadi@uk-essen.de

Locations
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Germany
University Hospital Essen Recruiting
Essen, NRW, Germany, 4
Contact: Amir A Mahabadi, MD    +4920172384822    amir-abbas.mahabadi@uk-essen.de   
Sponsors and Collaborators
University Hospital, Essen
Investigators
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Principal Investigator: Amir A Mahabadi, MD University Hospital, Essen

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Responsible Party: Amir Abbas Mahabadi, Principal Investigator, University Hospital, Essen
ClinicalTrials.gov Identifier: NCT03787797     History of Changes
Other Study ID Numbers: 18-8402-BO
First Posted: December 25, 2018    Key Record Dates
Last Update Posted: December 27, 2018
Last Verified: December 2018
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: Yes
Plan Description: IPD will be made available upon request.

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Keywords provided by Amir Abbas Mahabadi, University Hospital, Essen:
Epicardial adipose tissue
Chest pain
Echocardiography
Coronary artery disease
Additional relevant MeSH terms:
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Coronary Artery Disease
Myocardial Ischemia
Coronary Disease
Acute Coronary Syndrome
Syndrome
Disease
Pathologic Processes
Heart Diseases
Cardiovascular Diseases
Arteriosclerosis
Arterial Occlusive Diseases
Vascular Diseases