Isometric Exercise and Endogenous Pain Inhibition
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|ClinicalTrials.gov Identifier: NCT03778476|
Recruitment Status : Recruiting
First Posted : December 18, 2018
Last Update Posted : December 18, 2018
|Condition or disease||Intervention/treatment||Phase|
|Fibromyalgia||Other: Isometric Exercise||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||60 participants|
|Intervention Model:||Crossover Assignment|
|Intervention Model Description:||The two groups will participate in two sessions receiving intervention or no intervention in a randomized manner.|
|Masking Description:||The participant is masked to the hypotheses of the treatment.|
|Official Title:||Isometric Exercise and Endogenous Pain Modulation|
|Actual Study Start Date :||May 25, 2018|
|Estimated Primary Completion Date :||August 2022|
|Estimated Study Completion Date :||August 2022|
Experimental: Isometric Exercise
Participants will perform a submaximal voluntary contraction of the quadriceps muscle to task failure.
Other: Isometric Exercise
Participants will be asked to hold a submaximal voluntary contraction of the quadriceps muscle as long as they can (task failure).
No Intervention: Quiet Rest
Participants will sit quietly for a period of time that mimics the exercise.
- Conditioned Pain Modulation [ Time Frame: baseline, immediately after exercise or quiet rest ]the change in pressure pain threshold (kPa) during or after the immersion of the foot in a cold water bath (approximately 6 degrees) compared with baseline (before foot submersion) constitutes the measure of conditioned pain modulation in this study.
- Vibration Perception Threshold [ Time Frame: baseline, immediately after exercise or quiet rest ]a biothesiometer will be used to measure sense of vibration (threshold) local and distal from the exercising muscle.
- Numerical Pain Rating Scale (NPRS) [ Time Frame: baseline, during exercise, and immediately after exercise or quiet rest ]in both sessions, pain intensity will be evaluated during ice water bath immersion (i.e. before and after exercise or quiet rest) and during exercise using an 11-point NPRS with 0 being no pain and 10 worst pain possible.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03778476
|Contact: Marie Hoeger Bement, PT, PhDfirstname.lastname@example.org|
|United States, Wisconsin|
|Milwaukee, Wisconsin, United States, 53233|
|Contact: Marie Hoeger Bement, PT, PhD 414-288-6738 email@example.com|
|Sub-Investigator: Ali Alsouhibani, PT, MS|
|Principal Investigator:||Marie Hoeger Bement, PT, PhD||Marquette University|
|Study Director:||Ali Alsouhibani, PT, MS||Marquette University|