Improving Electronic Written Communication in Aphasia (T-WRITE)
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|ClinicalTrials.gov Identifier: NCT03773419|
Recruitment Status : Recruiting
First Posted : December 12, 2018
Last Update Posted : January 6, 2020
People with aphasia have difficulty with writing and often struggle to use electronic communication that connects people to one another. The goal of this project is to evaluate the extent to which a novel treatment (T-WRITE) improves written language function and the use of text messaging; we also evaluate whether there are subsequent positive effects on the participant's social connectedness and ultimately health-related quality of life (HRQOL).
T-WRITE involves choral reading and repeated writing of sentences via texting. Participants work intensively and independently at home on a laptop computer. A virtual therapist directs the participant to practice copying and independently writing phrases and short sentences using the typing feature on a cellular phone. The specific objective of this randomized clinical trial is to compare T-WRITE to ORLA+WTG, a similar treatment that targets written expression using handwriting.
|Condition or disease||Intervention/treatment||Phase|
|Aphasia||Behavioral: Texting Intervention (T-WRITE) Behavioral: HandWriting Intervention (ORLA+WTG)||Not Applicable|
An acquired impairment in writing, also known as agraphia, is a characteristic symptom of aphasia, i.e., a language disorder resulting from damage to the language centers of the brain. Written communication via text and instant messaging, electronic mail, and various types of social media has become an increasingly important part of everyday life in our technology driven society. Consequently, difficulty with written expression can significantly restrict people with aphasia from participation in community life, including social, professional, and educational realms. Improving writing in persons with aphasia could improve communication, increase access to information, reduce isolation and facilitate social connectedness. Furthermore, delivering writing treatment via an electronic modality, such as texting, could be particularly advantageous given the increasing reliance on electronic communication. This study investigates the efficacy of T-WRITE, a computer-based writing treatment for aphasia that targets phrase/sentence level writing using texting. Its aims are to: 1) evaluate the efficacy of computer-based texting treatment for improving written communication in persons with aphasia and 2) assess the extent to which improvements in electronic written communication impact social connectedness and health-related quality of life (HRQOL). This will be accomplished via a randomized controlled trial across two sites that compares computer-based texting treatment (T-WRITE) to a control group that receives a hand-writing treatment (ORLA+WTG).
The intervention is delivered via computer using state-of-the-art virtual therapist technology. A perceptive, life-like animated computer agent (virtual therapist), using visible speech, guides the participant so he or she can independently work through the set of choral reading and writing activities (see figure above showing a screen shot of the virtual therapist). The objective is to assure an optimal learning experience in the comfort of the participant's home by using a virtual therapist with accurate visible speech feedback. The virtual therapist reads aloud, speaks with accurate visible speech, highlights and repeats words and sentences, directs the participant to copy/write phrases or sentences, and provides guidance much like a real therapist. The sequence of steps in the ORLA+WTG and the T-WRITE treatments are identical. The output modality for participants randomized to T-WRITE is texting using a cellular phone whereas participants in the ORLA+WTG will hand-write their responses using pen and paper. Participants will practice their writing for 90 minutes a day, 6 days a week for 4 weeks.
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||60 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||Single (Outcomes Assessor)|
|Official Title:||Improving Electronic Written Communication in Persons With Aphasia: A Clinical Trial|
|Actual Study Start Date :||September 20, 2018|
|Estimated Primary Completion Date :||October 2020|
|Estimated Study Completion Date :||December 2020|
Experimental: Texting Intervention (T-WRITE)
Computer-based treatment targeting written language via texting (90 minutes a day, 5 days a week for 4 weeks)
Behavioral: Texting Intervention (T-WRITE)
Computer-based intervention, guided by a virtual therapist, that involves repeated listening, reading and writing sentences using a cellular phone
Active Comparator: HandWriting Intervention (ORLA+WTG)
Computer-based treatment targeting written language via handwriting (90 minutes a day, 5 days a week for 4 weeks)
Behavioral: HandWriting Intervention (ORLA+WTG)
Computer-based intervention, guided by a virtual therapist, that involves repeated listening, reading and writing sentences using pen and paper
- Western Aphasia Battery-Revised (WAB-R) Writing subtest [ Time Frame: Change from pre-treatment to post-treatment (i.e. following completion of 36 hours of treatment at 4 weeks) ]Performance-based measure of written language; score ranges from 0 - 100
- Stroke and Aphasia Quality of Life Scale (SAQOL-39) [ Time Frame: Change from pre-treatment to post-treatment (i.e. following completion of 36 hours of treatment at 4 weeks) ]Self-report measure of health-related quality of life, validated with persons with aphasia; provides a total mean score that ranges from 1 - 39.
- The Friendship Scale [ Time Frame: Change from pre-treatment to post-treatment (i.e. following completion of 36 hours of treatment at 4 weeks) ]Six-item self-report scale that measures dimensions that contribute to social isolation and social connection. Each item is scored on a 5-point scale (0-4); overall score ranges from 1-24.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03773419
|Contact: Elissa Conlon, MAfirstname.lastname@example.org|
|Contact: Leora Cherney, PhDemail@example.com|
|United States, Illinois|
|Shirley Ryan AbilityLab||Recruiting|
|Chicago, Illinois, United States, 60611|
|Contact: Leora Cherney, PhD 312-238-6163 firstname.lastname@example.org|
|United States, Virginia|
|James Madison University||Recruiting|
|Harrisonburg, Virginia, United States, 22807|
|Contact: Jaime B Lee, PhD 540-568-2618 email@example.com|
|Principal Investigator:||Leora Cherney, PhD||Shirley Ryan AbilityLab|