Antibacterial Effect of Guava Leaves Extract Mouthwash Compared to Chlorhexidine Mouthwash in High Caries Risk Patients
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|ClinicalTrials.gov Identifier: NCT03773094|
Recruitment Status : Not yet recruiting
First Posted : December 12, 2018
Last Update Posted : December 12, 2018
This trial is to test the antibacterial effect of Guava leaves extract mouth wash compared to Chlorhexidine mouth wash in high caries risk patients.
Also salivary pH and patient satisfaction to taste will also be tested.
|Condition or disease||Intervention/treatment||Phase|
|High Caries Risk Patients Antimicrobial Effect Salivary pH Patient Satisfaction to Taste||Drug: Guava leaves extract Drug: Chlorhexidine||Phase 2 Phase 3|
This study is conducted to evaluate the effect of Guava leaves extract mouth wash on anti-bacterial activity against streptococcus mutans, salivary pH and patient satisfaction to taste compared to Chlorhexidine mouth wash.
P: Population with high caries risk patients I: Intervention by Guava leaves extract mouthwash C: Control is Chlorhexidine mouthwash O1: The primary outcome is antibacterial activity. O2: The secondary outcome is salivary pH O3: The tertiary outcome is patient satisfaction to taste
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||94 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||Double (Participant, Outcomes Assessor)|
|Official Title:||Effect of Guava Leaves Extract Mouth Wash on Antibacterial Activity, Salivary pH and Patient Satisfaction Compared to Chlorhexidine Mouth Wash in High Caries Risk Patients: A Randomized Control Clinical Trial|
|Estimated Study Start Date :||January 2019|
|Estimated Primary Completion Date :||November 2019|
|Estimated Study Completion Date :||January 2020|
Experimental: Guava leaves extract
A natural product that is prepared as a mouthwash
Drug: Guava leaves extract
Natural product : The leaves of the guava tree are full of antioxidants, anti-inflammatory agents, antibacterials, and even tannins that can have significant health benefits, from treating stomach troubles to chronic diseases like cancer
Other Name: Psidium guajava
Active Comparator: Chlorhexidine
chemical agent Chlorhexidine as a mouthwash
chemical agent used as a mouthwash against cariogenic bacteria. considered the gold standard
Other Name: Chlorhexidine glucnate
- Anti-bacterial effect against streptococcus mutans [ Time Frame: 3 months ]Antimicrobial effect against streptococcus mutans: saliva samples collected and total bacterial count measured after agar plates incubating, expressed in colony forming units
- Salivary pH [ Time Frame: 3 months ]
Saliva samples pH will be measured using digital pH meter to evaluate its efficacy in preventing the action of acidogenic bacteria in high caries risk patients.
It displays numerical value.
- Patient satisfaction to taste: questionnaire [ Time Frame: 3 months ]The patient will fill a questionnaire to assess patient satisfaction to taste after usage of the mouthwash. Nominal answers
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03773094
|Contact: Engy MM Kassem, Master's firstname.lastname@example.org|
|Contact: Mohamed A Khairy, PhDemail@example.com|