A New Breath for Malignant Hypertension: Implementation of the HAMA Cohort (HAMA)
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|ClinicalTrials.gov Identifier: NCT03755726|
Recruitment Status : Recruiting
First Posted : November 28, 2018
Last Update Posted : October 16, 2019
|Condition or disease|
Malignant hypertension is the most severe form of high blood pressure, fatal if left untreated. It has not disappeared, with an increasing incidence. Patients with the disease, mainly young (35 to 55 years of age), have an unfavorable cardiovascular prognosis (14% of cardiovascular and renal events at 4 years). Despite these facts, scientific research on the subject remains limited. The definitions and diagnostic criteria have not changed since 1929, and the therapeutic recommendations remain empirical.
This first prospective and multicentric registry will increase and modernize the knowledge of the disease. From these data, diagnostic and therapeutic recommendations based on solid scientific evidence could be developed.
The investigators want to first recruit 500 patients and define their prognosis at 5 years. The impact of the patient's phenotype, type and number of target organs affected will be studied.
A modern definition, adapted to these results, could be proposed. The epidemiology of the disease, the care pathways, the target organ disorders and the management carried out in the centers will be described in detail.
|Study Type :||Observational|
|Estimated Enrollment :||500 participants|
|Official Title:||A New Breath for Malignant Hypertension: Implementation of the HAMA Cohort|
|Actual Study Start Date :||September 20, 2019|
|Estimated Primary Completion Date :||September 20, 2029|
|Estimated Study Completion Date :||September 20, 2029|
- prognosis [ Time Frame: 5 years ]5-year prognosis for patients with malignant hypertension
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Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03755726