Biometry of Occult Lens Subluxation Misdiagnosed as Primary Acute Angle Closed Glaucoma

• ClinicalTrials.gov Identifier: NCT03752710
• Recruitment Status: Completed
• First Posted: November 26, 2018
• Last Update Posted: November 27, 2018
• Sponsor: Tianjin Medical University Eye Hospital
• Information provided by (Responsible Party): Lv Yingjuan, Tianjin Medical University Eye Hospital

Study Description

Brief Summary:

In this work, we evaluated the biometry data of lens subluxation inducing acute angle closure which were misdiagnosed as primary angle closure at the first visit, and compared with the data of chronic angle closure glaucoma, cataract, primary acute angle closure.

Condition or disease
Subluxation of Lens

Study Design

• Study Type: Observational
• Actual Enrollment: 183 participants
• Observational Model: Case-Control
• Time Perspective: Retrospective
• Official Title: Biometric Indicators of Eyes With Occult Lens Subluxation
• Actual Study Start Date: January 2016
• Actual Primary Completion Date: December 2017
• Actual Study Completion Date: December 2017

Groups and Cohorts

Group/Cohort
Acute primary angle closure
Acute secondary angle closure induced by LS
Cataract
Primary chronic angle closed glaucoma

Outcome Measures

Primary Outcome Measures :

1. Eye anterior segment biometry [ Time Frame: 1 day ]
   Anterior segment biometry measure by Lenstar LS900
2. Intraocular pressure [ Time Frame: 1 year ]
   Intraocular pressure was measured by Goldmann tonometer
3. visual acuity [ Time Frame: 1 year ]
   visual acuity before and after surgery

Eligibility Criteria

• Ages Eligible for Study: Child, Adult, Older Adult
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: No
• Sampling Method: Non-Probability Sample

Study Population

This retrospective case study included 17 eyes of 17 patients with ASAC-LS, who were misdiagnosed with APACG on their first visit. In addition, 56 eyes of 56 patients diagnosed with APACG, 54 eyes of 54 patients diagnosed with CPACG, and 56 eyes of 56 patients diagnosed with cataract were also included. All of the patients were admitted from Jan 10, 2016 to Dec 28, 2017 in Tianjin Medical University Hospital. This study was conducted in accordance with the Helsinki Declaration and was approved by the Ethics Committee of Tianjin Medical University Eye Hospital.

Criteria

ASAC-LS was diagnosed according to the following criteria, including sudden pain in the eye, decreased vision with or without nausea and vomiting. Slit lamp microscopy reveals phacodonesis, lens inclination or vitreous herniation into the anterior chamber, central and peripheral shallow anterior chamber, and asymmetric iris bulge. All patients were confirmed during the surgery to have LS.

APACG was diagnosed with the following criteria6, 7 8, including substantially elevated IOP and closed angle, acute eye pain, blurred vision, or nausea and vomiting. More importantly, ischemic injury caused by acute ocular hypertension, ciliary or mixed congestion, corneal edema, and glaucoma flecks should be detected.

The diagnostic criteria of CPACG included narrow angle with anterior synechiae of varying widths, IOP > 22 mmHg, and glaucomatous optic disc damage and visual field shrinkage9-11 The angle closure should be more than two quadrants, yet there was no ischemic injury in the anterior segment caused by acute ocular hypertension.

Exclusion criteria were history of laser peripheral iridotomy or peripheral iridectomy, glaucoma filtration surgery, angle closure caused by ocular trauma, uveitis, neovascularization or lens swelling or hyper mature lens. The patients with acute angle closure in both eyes were excluded. The subjects in which Lenstar LS900 examination could not be performed because of severe lens opacity or corneal edema were also not included in the study.

Contacts and Locations

No Contacts or Locations Provided

More Information

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):

Xing X, Huang L, Tian F, Zhang Y, Lv Y, Liu W, Liu A. Biometric indicators of eyes with occult lens subluxation inducing secondary acute angle closure. BMC Ophthalmol. 2020 Mar 5;20(1):87. doi: 10.1186/s12886-020-01355-7.

• Responsible Party: Lv Yingjuan, Dr Lv Yingjuan, Tianjin Medical University Eye Hospital
• ClinicalTrials.gov Identifier: NCT03752710
• Other Study ID Numbers: Tianjin LS study
• First Posted: November 26, 2018
• Last Update Posted: November 27, 2018
• Last Verified: November 2018

• Studies a U.S. FDA-regulated Drug Product: No
• Studies a U.S. FDA-regulated Device Product: No

Additional relevant MeSH terms:

Joint Dislocations; Lens Subluxation; Joint Diseases; Musculoskeletal Diseases; Wounds and Injuries; Lens Diseases; Eye Diseases