Metabolomic Profiling of in Patients With type2 Diabetes
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|ClinicalTrials.gov Identifier: NCT03725709|
Recruitment Status : Recruiting
First Posted : October 31, 2018
Last Update Posted : November 2, 2018
|Condition or disease||Intervention/treatment|
|Diagnoses Disease Diabetes Mellitus, Type 2||Procedure: spinal anesthesia|
|Study Type :||Observational|
|Estimated Enrollment :||240 participants|
|Official Title:||Metabolomic Profiling of Cerebrospinal Fluid and Plasma in Patients With type2 Diabetes|
|Actual Study Start Date :||August 1, 2016|
|Estimated Primary Completion Date :||July 31, 2019|
|Estimated Study Completion Date :||December 31, 2019|
Procedure: spinal anesthesia
Plan to enroll 120 Type 2 diabetes and 120 non-diabetes patients with received spinal anesthesia.Blood will be collected at time point of pre-anesthesia 10 minutes and CSF samples will be collected at time point during spinal anesthesia induction. Blood will be collected, drawn into EDTA-coated tube.
- Find the reliable biomarkers, using metabolomic analysis [NMR, LC-MS] [ Time Frame: Through study completion, an average of 1 year ]Use metabolomic analysis to connect CSF and blood metabolomic profiles information for further clarification of the influence of DM in CNS and expect to find new reliable biomarkers in diabetes patient for early predict DM progression and outcome.
- Exam metabolic profiles of CSF and plasma in diabetes. (Metabolites analysis of CSF and plasma) [ Time Frame: Through study completion, an average of 1 year ]Metabolites analysis of CSF and plasma will be investigated by NMR, LC-MS. Peak lists of all NMR and LC/MS/MS spectra will be searched against the database through a web server for metabolomic data analysis and further establish the CSF Metabolome Database.
Biospecimen Retention: Samples With DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03725709
|Chang Gung Memorial Hospital||Recruiting|
|Taoyuan, Taiwan, 333|
|Contact: Fu Chao Liu, MD,PHD +886 975365718 firstname.lastname@example.org|