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Trial record 1 of 42 for:    Exercise | Madison, Wisconsin, U.S.
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Cerebrovascular Response to Acute Exercise

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ClinicalTrials.gov Identifier: NCT03722953
Recruitment Status : Suspended (Due to COVID-19)
First Posted : October 29, 2018
Last Update Posted : November 4, 2021
Sponsor:
Information provided by (Responsible Party):
University of Wisconsin, Madison

Brief Summary:
Cerebrovascular function and peripheral vascular function will be measured in healthy young adults, before and after acute bouts of aerobic exercise at various intensities.

Condition or disease Intervention/treatment Phase
Healthy Physical Activity Other: Control Other: Aerobic Exercise Not Applicable

Detailed Description:

Acute bouts of aerobic exercise have been shown to enhance vascular reactivity of the peripheral circulation; however, the effects of a single exercise session on the cerebral circulation are unknown. This study will measure cerebrovascular function and peripheral vascular function before and after aerobic exercise at high and low intensities.

The research aims are:

  1. To determine if a single bout of aerobic exercise acutely enhances cerebrovascular function
  2. To determine the effect of aerobic exercise intensity and dose on cerebrovascular function in healthy adults.
  3. To determine if the acute exercise-induced changes in cerebrovascular function are associated with acute exercise-induced changes in peripheral vascular function in healthy adults.

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Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 20 participants
Allocation: N/A
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Official Title: The Role of Shear Stress in the Cerebrovascular Response to Acute Exercise
Actual Study Start Date : December 1, 2018
Estimated Primary Completion Date : July 2022
Estimated Study Completion Date : September 2022

Arm Intervention/treatment
Aerobic Exercise

Control: Cerebrovascular function and peripheral vascular function will be measured.

Aerobic Exercise: Across four separate visits, participants will perform light intensity exercise, light intensity exercise plus an additional task, vigorous intensity exercise and vigorous intensity exercise to match the energy expenditure of light intensity exercise visit.

Other: Control
  1. Ultrasound
  2. Blood Pressure
  3. Heart Rate
  4. Oxygen Saturation

Other: Aerobic Exercise
  1. Ultrasound
  2. Blood Pressure
  3. Heart Rate
  4. Oxygen Saturation




Primary Outcome Measures :
  1. Cerebrovascular function [ Time Frame: Change in cerebrovascular function: measurements occur at baseline and 90 minutes post aerobic exercise to quantify magnitude of change. ]
    Utilize ultrasound to measure a change in blood flow velocity in response to a breathing test

  2. Peripheral vascular function [ Time Frame: Change in peripheral vascular function: measurements occur at baseline and 60 minutes post aerobic exercise to quantify magnitude of change. ]
    Utilize ultrasound to measure a change in brachial artery diameter in response to reactive hyperemia



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Ages Eligible for Study:   20 Years to 40 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Between 20-40 years old
  • BMI < 30 kg/m2
  • Recreationally active
  • Experience running on a treadmill

Exclusion Criteria:

  • Current smoker
  • History or evidence of: hepatic disease, renal disease, hematological disease, cardiovascular disease, stroke/neurovascular disease, diabetes
  • Taking blood pressure medication
  • History of depression or other mood related disorders
  • Part of a vulnerable population (e.g. pregnant women, prisoner, individuals lacking capacity to consent, etc.)

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03722953


Locations
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United States, Wisconsin
Gymnasium-Natatorium
Madison, Wisconsin, United States, 53706
Sponsors and Collaborators
University of Wisconsin, Madison
Publications:

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Responsible Party: University of Wisconsin, Madison
ClinicalTrials.gov Identifier: NCT03722953    
Other Study ID Numbers: 2018-0783
A176000 ( Other Identifier: UW Madison )
EDUC/KINESIOLOGY ( Other Identifier: UW Madison )
Protocol Version 10/23/2018 ( Other Identifier: UW Madison )
First Posted: October 29, 2018    Key Record Dates
Last Update Posted: November 4, 2021
Last Verified: November 2021
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Keywords provided by University of Wisconsin, Madison:
Exercise
Treadmill
Vascular Function
Intensity