Cerebrovascular Response to Acute Exercise
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT03722953|
Recruitment Status : Suspended (Due to COVID-19)
First Posted : October 29, 2018
Last Update Posted : November 4, 2021
|Condition or disease||Intervention/treatment||Phase|
|Healthy Physical Activity||Other: Control Other: Aerobic Exercise||Not Applicable|
Acute bouts of aerobic exercise have been shown to enhance vascular reactivity of the peripheral circulation; however, the effects of a single exercise session on the cerebral circulation are unknown. This study will measure cerebrovascular function and peripheral vascular function before and after aerobic exercise at high and low intensities.
The research aims are:
- To determine if a single bout of aerobic exercise acutely enhances cerebrovascular function
- To determine the effect of aerobic exercise intensity and dose on cerebrovascular function in healthy adults.
- To determine if the acute exercise-induced changes in cerebrovascular function are associated with acute exercise-induced changes in peripheral vascular function in healthy adults.
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||20 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Primary Purpose:||Basic Science|
|Official Title:||The Role of Shear Stress in the Cerebrovascular Response to Acute Exercise|
|Actual Study Start Date :||December 1, 2018|
|Estimated Primary Completion Date :||July 2022|
|Estimated Study Completion Date :||September 2022|
Control: Cerebrovascular function and peripheral vascular function will be measured.
Aerobic Exercise: Across four separate visits, participants will perform light intensity exercise, light intensity exercise plus an additional task, vigorous intensity exercise and vigorous intensity exercise to match the energy expenditure of light intensity exercise visit.
Other: Aerobic Exercise
- Cerebrovascular function [ Time Frame: Change in cerebrovascular function: measurements occur at baseline and 90 minutes post aerobic exercise to quantify magnitude of change. ]Utilize ultrasound to measure a change in blood flow velocity in response to a breathing test
- Peripheral vascular function [ Time Frame: Change in peripheral vascular function: measurements occur at baseline and 60 minutes post aerobic exercise to quantify magnitude of change. ]Utilize ultrasound to measure a change in brachial artery diameter in response to reactive hyperemia
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03722953
|United States, Wisconsin|
|Madison, Wisconsin, United States, 53706|