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Gum Acacia and Blood Glucose

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT03716479
Recruitment Status : Completed
First Posted : October 23, 2018
Last Update Posted : October 4, 2019
Sponsor:
Information provided by (Responsible Party):
University of Minnesota

Brief Summary:
This study will provide needed insight on the satiety and blood glucose and l effects of the soluble fiber gum acacia at 20g and 40g doses.

Condition or disease Intervention/treatment Phase
Diet Modification Other: Low Fiber Other: High Fiber Other: Placebo/Control Not Applicable

Detailed Description:
This is a randomized, single-blind, crossover, intervention study testing the satiety and blood glucose effects of the soluble fiber gum acacia.

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 48 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Intervention Model Description: subjects will consume 0, and 2 doses of acacia gum
Masking: Double (Participant, Investigator)
Masking Description: fiber will be mixed into orange juice
Primary Purpose: Prevention
Official Title: The Effect of Gum Acacia on Satiety, Glycemic Response and Gastrointestinal Tolerance
Actual Study Start Date : October 9, 2018
Actual Primary Completion Date : August 31, 2019
Actual Study Completion Date : September 1, 2019

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Blood Sugar
Drug Information available for: Acacia

Arm Intervention/treatment
Experimental: 0 fiber
0 grams fiber added to orange juice
Other: Placebo/Control
No acacia gum will be added to orange juice.

Experimental: low fiber
20 grams of acacia gum added to orange juice
Other: Low Fiber
20 g of acacia gum will be added to orange juice

Experimental: high fiber
40 grams of acacia gum added to orange juice
Other: High Fiber
40 g of acacia gum will be added to orange juice




Primary Outcome Measures :
  1. Blood glucose levels [ Time Frame: 0, 30, 60, 120, 180, and 240 minutes after breakfast; Area under the curve (AUC) will be calculated for each treatment ]
    Blood will be taken via finger stick

  2. Appetite Sensation [ Time Frame: 15, 30, 45, 60, 90, 120, 180 and 240 minutes after breakfast; Area under the curve (AUC) will be calculated for each treatment ]
    Subjective visual analog scale (VAS) will be utilized to assess hunger, fullness and desire to eat



Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


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Ages Eligible for Study:   18 Years to 65 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria: BMI between 18 and 29 kg/m2

Exclusion Criteria:

  • distaste for bagels and cream cheese, orange juice or cheese pizza;
  • current smoker;
  • restrained eating habits;
  • recent weight change;
  • any history of disease or significant past medical history;
  • are vegetarian;
  • do not normally eat breakfast or lunch;
  • pregnant or lactating;
  • irregular menstrual cycles.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03716479


Locations
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United States, Minnesota
Department of Food Science and Nutrition
Saint Paul, Minnesota, United States, 55108
Sponsors and Collaborators
University of Minnesota
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Responsible Party: University of Minnesota
ClinicalTrials.gov Identifier: NCT03716479    
Other Study ID Numbers: STUDY00004203
First Posted: October 23, 2018    Key Record Dates
Last Update Posted: October 4, 2019
Last Verified: October 2019
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No