Central Pain Mechanisms in Patients With Hand-Osteoarthritis, Psoriatic Arthritis and Healthy Controls
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|ClinicalTrials.gov Identifier: NCT03703934|
Recruitment Status : Suspended (COVID-19)
First Posted : October 12, 2018
Last Update Posted : March 18, 2020
In this trial different parts of the pain signalling system involved in two rheumatic diseases - painful hand osteoarthritis and psoriatic arthritis, is examined. These measurements will be compared to those of healthy volunteers
The hypothesis is that patients with hand osteoarthritis and psoriatic arthritis react differently to painful and non-painful stimuli compared with the healthy volunteers.
The aim is to recruit 66 patients with painful hand-osteoarthritis, 66 patients with painful psoriatic arthritis and 66 healthy subjects not currently suffering from any pain conditions.
After completing an informed consent form subjects will participate in a single clinical visit. The pain signalling system is examined using pressure algometry and cuff algometry. A pressure algometer is a pistol shaped device that elicits pressure through a rod and a cuff algometer is akin to a blood pressure cuff. Different thresholds will be measured, such as when the sensation of pressure becomes painful and when the painful pressure becomes unbearable.
Participants will also get hand strength tested, have their joints examined and answer questionnaires regarding daily function and quality of life.
Furthermore participants will get blood drawn which is analysed for the presence of markers of inflammation and joint degeneration.
|Condition or disease|
|Arthritis, Psoriatic Hand Osteoarthritis|
|Study Type :||Observational|
|Estimated Enrollment :||180 participants|
|Official Title:||Central Pain Mechanisms in Patients With Hand-Osteoarthritis, Psoriatic Arthritis and Healthy Controls|
|Actual Study Start Date :||October 20, 2018|
|Estimated Primary Completion Date :||June 30, 2020|
|Estimated Study Completion Date :||June 30, 2020|
Patients with painful psoriatic arthritis
Patients with painful nodal non-erosive hand osteoarthritis
Patients without a painful condition
- Between group difference in Pressure pain threshold (PPT) [ Time Frame: Day One ]Difference PPT between groups measured in kPa
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03703934
|Department of Rheumatology Aalborg Universityhospital North|
|Aalborg, Denmark, 9000|