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Effects of Aerobic and Resistance Training on Abdominal Fat Loss

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ClinicalTrials.gov Identifier: NCT03700827
Recruitment Status : Recruiting
First Posted : October 9, 2018
Last Update Posted : July 19, 2019
Sponsor:
Collaborator:
Washington University School of Medicine
Information provided by (Responsible Party):
Southern Illinois University Edwardsville

Brief Summary:
Study the effects of different exercise modes on total and regional adiposity variation in subcutaneous and visceral adipose tissue (VAT and SAT). The investigators hypothesize that total abdominal will improve for all the exercise groups compared to the control group. When comparing intervention groups: 1) no differences on the degree of improvement in total abdominal fat depots (VAT and SAT) 2) different degree of change when comparing specific sections at VAT and SAT are expected.

Condition or disease Intervention/treatment Phase
Obesity, Abdominal Other: Resistance Training Other: Aerobic Training Not Applicable

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Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 15 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Effects of Aerobic and Resistance Training on Abdominal Fat Loss
Actual Study Start Date : October 1, 2017
Estimated Primary Completion Date : May 2020
Estimated Study Completion Date : May 2020

Arm Intervention/treatment
Experimental: Resistance Training Group
Resistance training will consist of 3 whole body circuits per week for 3 weeks lasting approximately 1 hour per session. All major muscle groups will be involved (leg press, bent-over-row, bench press, back squat, dumbbell jump squats, dead-lifts, and weighted abdominal crunches). Each participant will go through each circuit three times with 30 seconds between each exercise and 2 minutes between each set.
Other: Resistance Training
High-intensity Resistance Training Group

Experimental: Aerobic Training Group
Aerobic interval training will consist of 3 sessions/week for 3 weeks for approximately 45-50 minutes per session depending on exercise energy expenditure. There will be two periods of intervals. The first period will be 3 minutes of high-intensity activity and the second period will be reduced to moderate-intensity for 2 minutes. The speed/incline will change depending on the participants perception or Borg's rating of perceived exertion. Intensity will be measured using Lactate levels after each session.
Other: Aerobic Training
Aerobic Interval Training Group

No Intervention: Control Group
The control group must attend sessions but will not exercise.



Primary Outcome Measures :
  1. Changes in Visceral Abdominal Tissue (VAT) [ Time Frame: 2 assessment periods: at baseline and week 4 ]
    Changes in VAT will be measured using Magnetic Resonance Imaging


Secondary Outcome Measures :
  1. Changes in Subcutaneous Abdominal Tissue (SAT) [ Time Frame: 2 assessment periods: at baseline and week 4 ]
    Changes in SAT will be measured using Magnetic Resonance Imaging

  2. Changes in Muscular Strength [ Time Frame: 2 assessment periods: at baseline and week 4 ]
    Changes in muscular strength will be assessed by one-repetition maximum test on leg press and bench press

  3. Changes in Cardiorespiratory Function [ Time Frame: 2 assessment periods: at baseline and week 4 ]
    Changes in cardiorespiratory will measured on a treadmill with a metabolic cart

  4. Changes in fat mass (kg) [ Time Frame: 2 assessment periods: at baseline and week 4 ]
    Changes in fat mass will be measured using dual-energy x-ray absorptiometry

  5. Changes in relative body fat (%BF) [ Time Frame: 2 assessment periods: at baseline and week 4 ]
    Changes in body composition (relative body fat, lean body mass and fat mass) will be measured using dual-energy x-ray absorptiometry

  6. Changes in relative lean body mass (kg) [ Time Frame: 2 assessment periods: at baseline and week 4 ]
    Changes in lean body mass will be measured using dual-energy x-ray absorptiometry

  7. Changes in Lipid profile (TG, Total Cholesterol, HDL2 HDL3, LDL) [ Time Frame: 2 assessment periods: at baseline and week 4 ]
    Samples will be processed to obtain serum and plasma, and stored at -80°c until analysis

  8. Changes in concentration of Troponin [ Time Frame: 2 assessment periods: at baseline and week 4 ]
    Will be performed using a Luminex MAGPIX System with xPONENT 4.2

  9. Changes in concentration of Fibrinogen [ Time Frame: 2 assessment periods: at baseline and week 4 ]
    Will be performed using a Luminex MAGPIX System with xPONENT 4.2

  10. Changes in concentration of C-reactive protein (CRP) [ Time Frame: 2 assessment periods: at baseline and week 4 ]
    Will be performed using a Luminex MAGPIX System with xPONENT 4.2

  11. Changes in concentration of IL-6 [ Time Frame: 2 assessment periods: at baseline and week 4 ]
    Will be performed using a Luminex MAGPIX System with xPONENT 4.2

  12. Changes in concentration of IL-10 [ Time Frame: 2 assessment periods: at baseline and week 4 ]
    Will be performed using a Luminex MAGPIX System with xPONENT 4.2

  13. Changes in concentration of TNF-alpha [ Time Frame: 2 assessment periods: at baseline and week 4 ]
    Will be performed using a Luminex MAGPIX System with xPONENT 4.2



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Ages Eligible for Study:   18 Years to 35 Years   (Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • 30 - 39.9 kg/m2 BMI
  • White/Caucasian
  • Female
  • Sedentary

Exclusion Criteria:

  • Known cardiovascular, pulmonary, metabolic disease
  • Pregnant females
  • Any excluded criteria with MRI scans (i.e. certain metal implants, recent tattoos)
  • Diabetic
  • Hypertension
  • Cigarette smoking
  • MRI related contraindications (metal, no removable devices, etc.)

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03700827


Contacts
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Contact: Maria Fernandez del Valle, PhD 6186505905 marfern@siue.edu

Locations
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United States, Illinois
Southern Illinois University of Edwardsville Recruiting
Edwardsville, Illinois, United States, 62026
Contact: Erik Kirk, PhD    618-650-2938    ekirk@siue.edu   
Sponsors and Collaborators
Southern Illinois University Edwardsville
Washington University School of Medicine
Investigators
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Principal Investigator: Maria Fernandez del Valle, PhD Southern Illinois University of Edwardsville

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Responsible Party: Southern Illinois University Edwardsville
ClinicalTrials.gov Identifier: NCT03700827     History of Changes
Other Study ID Numbers: 16-1208-4C-2
First Posted: October 9, 2018    Key Record Dates
Last Update Posted: July 19, 2019
Last Verified: July 2019
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: Undecided

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Keywords provided by Southern Illinois University Edwardsville:
Abdominal Fat
Visceral Adipose Tissue
Subcutaneous Adipose Tissue
Exercise
Intervention
Additional relevant MeSH terms:
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Obesity, Abdominal
Obesity
Overnutrition
Nutrition Disorders