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China Health Big Data (China biobank)

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ClinicalTrials.gov Identifier: NCT03699228
Recruitment Status : Recruiting
First Posted : October 8, 2018
Last Update Posted : October 9, 2018
Sponsor:
Collaborators:
Chinese PLA General Hospital
Ruijin Hospital
Huashan Hospital
Henan Provincial Hospital
The Affiliated Hospital Of Guizhou Medical University
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
The First Affiliated Hospital of Zhengzhou University
First Affiliated Hospital Xi'an Jiaotong University
The renmin hospital of wuhan university
Nanjing BenQ Hospital
China japan hospital
xinan hospital
Wu Hu Yijishan hospital
The fifth affiliated hospital of zhong shan university
Information provided by (Responsible Party):
xiaoguang Cheng, Beijing Jishuitan Hospital

Brief Summary:
In this nationwide multi center study the investigators combine the low dose chest CT scan data with QCT technology, to measure the BMD of spine, VAT and liver fat in the health check subjects. The aim of this study is to evaluate the performance of QCT in the health check field, and further to evaluate the prevalence of osteoporosis, obesity and liver steatosis in health check population across China.

Condition or disease
Osteoporosis Obesity Liver Steatoses

Detailed Description:
Low dose Chest CT scan is the standard for lung cancer in the health check center in China. Quantitative computed tomography (QCT) is utilizing the CT raw data to measure the bone mineral density (BMD), the visceral fat (VAT) and liver fat content in human, which can be widely used in the diagnosis of osteoporosis, the assessment of obesity and liver steatosis. In this nationwide multi center study the investigators combine the low dose chest CT scan data with QCT technology, to measure the BMD of spine, VAT and liver fat in the health check subjects. This study is to evaluate the performance of QCT in the health check field, and further to evaluate the prevalence of osteoporosis, obesity and liver steatosis in health check population across China.

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Study Type : Observational
Estimated Enrollment : 30000 participants
Observational Model: Other
Time Perspective: Prospective
Official Title: China Nationwide Multi Center Big Data Study on the Quantitative Computed Tomography (QCT) and Health Status of Check -up Population
Actual Study Start Date : December 1, 2017
Estimated Primary Completion Date : June 30, 2020
Estimated Study Completion Date : December 31, 2020

Resource links provided by the National Library of Medicine





Primary Outcome Measures :
  1. The spinal volumetric bone mineral density (vBMD) [ Time Frame: 2 year ]
    The volumetric bone mineral density of L1-2 measured by QCT


Secondary Outcome Measures :
  1. The visceral adipose tissue (VAT) [ Time Frame: 2 year ]
    The visceral adipose tissue (VAT) measured by quantitative computed tomography (QCT)

  2. Liver fat [ Time Frame: 2 years ]
    Liver fat measurement by quantitative computed tomography (QCT)



Information from the National Library of Medicine

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Ages Eligible for Study:   30 Years to 90 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
General health check population
Criteria

Inclusion Criteria:

health check subjects 30-90 years old low dose chest CT scan

Exclusion Criteria:

pregnant women metal implant in the CT scan area


Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03699228


Contacts
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Contact: xiaoguang cheng, md 0086-010-58516947 xiao65@263.net
Contact: xiaoxia fu, md 0086-13683132746

Locations
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China, Anhui
Wu Hu Yijishan Hospital Recruiting
Wu Hu, Anhui, China, 100035
Contact: xiaojun zha    008613705533568      
China, Beijing
Beijing Jishuitan hospital Recruiting
Beijing, Beijing, China, 100035
Contact: Kai Li, PhD    008615801633664      
Principal Investigator: Ling Wang, MD         
China, Guizhou
The first affiliated hospital of Guiyang Medical University Recruiting
Guiyang, Guizhou, China
Contact: Xia Du, MD    008613765071289      
China, Henan
The first affiliated hospital of Zhengzhou University Recruiting
Zhengzhou, Henan, China
Contact: Yan Wu, MD    008613803843588      
China, Shanghai
Hua Shan hospital Recruiting
Shanghai, Shanghai, China
Contact: Shuang chen    008613601717952      
Shanghai Ruijin hospital Recruiting
Shanghai, Shanghai, China
Contact: Yong Lu, MD    008613701995934      
Sponsors and Collaborators
Beijing Jishuitan Hospital
Chinese PLA General Hospital
Ruijin Hospital
Huashan Hospital
Henan Provincial Hospital
The Affiliated Hospital Of Guizhou Medical University
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
The First Affiliated Hospital of Zhengzhou University
First Affiliated Hospital Xi'an Jiaotong University
The renmin hospital of wuhan university
Nanjing BenQ Hospital
China japan hospital
xinan hospital
Wu Hu Yijishan hospital
The fifth affiliated hospital of zhong shan university
Investigators
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Principal Investigator: xiaoguang cheng, MD Beijing Jishuitan Hospital
Principal Investigator: qiang zeng General PLA hospital

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Responsible Party: xiaoguang Cheng, professor of radiology, chairman of department, Beijing Jishuitan Hospital
ClinicalTrials.gov Identifier: NCT03699228     History of Changes
Other Study ID Numbers: jst2018
First Posted: October 8, 2018    Key Record Dates
Last Update Posted: October 9, 2018
Last Verified: October 2018

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No

Keywords provided by xiaoguang Cheng, Beijing Jishuitan Hospital:
Bone mineral density, quantitative computed tomography, Osteoporosis, obesity, liver steatosis

Additional relevant MeSH terms:
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Osteoporosis
Fatty Liver
Bone Diseases, Metabolic
Bone Diseases
Musculoskeletal Diseases
Metabolic Diseases
Liver Diseases
Digestive System Diseases