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Effects of Yoga, Strength Training and Aerobic Exercise on Cognition in Adult Cancer Survivors

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ClinicalTrials.gov Identifier: NCT03650322
Recruitment Status : Completed
First Posted : August 28, 2018
Last Update Posted : July 1, 2020
Sponsor:
Information provided by (Responsible Party):
Neha P. Gothe, University of Illinois at Urbana-Champaign

Brief Summary:
The investigators propose to compare the effects of a 12-week, supervised, site-based group yoga intervention on cognitive function, functional fitness, and well-being in middle-aged cancer survivors. Subjects will be randomly assigned to one of three exercise conditions: a yoga group, an aerobic walking group or a strength training group. All sessions (2-3 times per week) will be led by a trained exercise leader for a total of 150 minutes of exercise each week for the 12-week intervention.

Condition or disease Intervention/treatment Phase
Cancer Cancer-related Problem/Condition Exercise Behavioral: Yoga Behavioral: Stretching and Toning Behavioral: Aerobic Walking Not Applicable

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 78 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Official Title: Effects of Yoga, Strength Training and Aerobic Exercise on Cognition in Adult Cancer Survivors
Actual Study Start Date : October 1, 2018
Actual Primary Completion Date : May 30, 2020
Actual Study Completion Date : May 30, 2020

Resource links provided by the National Library of Medicine


Arm Intervention/treatment
Experimental: Yoga Practice
Participants will be led through a beginner yoga course taught by a certified yoga instructor. Classes will meet twice a week for 75 minutes each for the duration of 12 weeks. Sessions will focus on yoga postures, breathing, and meditative practices and may utilize mats, blocks, belts, and blankets.
Behavioral: Yoga
12 weeks, total of 150 minutes of exercise per week.

Active Comparator: Stretching and Toning
This 12 week, progressive stretching and toning course will aid participants in building whole body strength and flexibility by utilizing weights, chairs, mats, and various other exercise equipment. Sessions will meet three times a week for 50 minutes and will offer 'easy' and 'hard' modifications taught by an exercise leader.
Behavioral: Stretching and Toning
12 weeks, total of 150 minutes of exercise per week.

Experimental: Aerobic Walking
Participants will partake in treadmill walking that encourages them to reach a pre-determined heart rate range. Sessions will be conducted three times a week for 50 minutes, and offer participants to self-select a speed and incline to meet their target heart rate zone.
Behavioral: Aerobic Walking
12 weeks, total of 150 minutes of exercise per week.




Primary Outcome Measures :
  1. Cognitive Function [ Time Frame: Change from baseline to 12 weeks will be reported ]
    Participants will complete part of the NIH Toolbox measures that assess cognitive function.


Secondary Outcome Measures :
  1. Cardiovascular Function [ Time Frame: Change from baseline to 12 weeks will be reported ]
    Participants will complete a submaximal exercise test to reach a target heart rate within 85% of the age-predicted maximum.



Information from the National Library of Medicine

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Ages Eligible for Study:   30 Years to 70 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • 30-70 years of age
  • Cancer diagnosis
  • 1 year since last cancer treatment (surgery, chemotherapy, and/or radiation)
  • Not planning to receive treatment during study period
  • Completion of Physical Activity Readiness Questionnaire (PAR-Q)
  • Ambulatory and absence of health conditions that may be exacerbated by yoga, walking, or strength training
  • Physician consent (if deemed necessary)
  • Low-active, i.e. less than 150 minutes/week of moderate to vigorous exercise, no current yoga practice (including within last six months)
  • Intention to remain in the Champaign-Urbana area over the study duration
  • Willingness to be randomly assigned to one of the three groups (yoga, aerobic walking, strength training)
  • Comfortable with reading, writing, and speaking English

Exclusion Criteria:

  • Below 30 or above 70 years of age
  • Cancer diagnosis of the brain
  • Less than 1 year since last treatment (surgery, chemotherapy, and/or radiation) or plans to receive treatment during study
  • Determined ambulatory or 'high risk' based on responses to PAR-Q
  • High-active (exercising more than 150 minutes/week in the last six months)
  • No consent from physician
  • Intent to be away from the Champaign-Urbana area for an extended period of time during the study
  • Inability to communicate effectively in English

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03650322


Locations
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United States, Illinois
University of Illinois at Urbana-Champaign
Urbana, Illinois, United States, 61801
Sponsors and Collaborators
University of Illinois at Urbana-Champaign
Investigators
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Principal Investigator: Neha Gothe, Ph.D., M.A. University of Illinois at Urbana-Champaign
Additional Information:
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
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Responsible Party: Neha P. Gothe, Assistant Professor, University of Illinois at Urbana-Champaign
ClinicalTrials.gov Identifier: NCT03650322    
Other Study ID Numbers: 18922
First Posted: August 28, 2018    Key Record Dates
Last Update Posted: July 1, 2020
Last Verified: June 2020
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No