Identification of Non-responders to Levothyroxine Therapy
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The purpose of this study is to assess differential effects of T4 and T3 on cell and tissue level
Condition or disease
HypothyroidismBiomarkersEndocrine System Diseases
Drug: LevothyroxinDrug: Liothyronine
15-20% of the patients with hypothyroidism remain symptomatic, despite adequate thyroxine substitution. Endocrinologists are split in their opinion on combination therapy with T4 and T3 on patients with poorly regulated hypothyroidism. There are no objective means, by which to identify individuals who would benefit from combination therapy. The purpose of this study is to assess differential effects of T4 and T3 on body temperature, metabolism, muscle strength and brain function. The main aim is to try to identify biomarkers reflecting different effects of T4 and T3 on cell and tissue level.
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Layout table for eligibility information
Ages Eligible for Study:
18 Years to 65 Years (Adult, Older Adult)
Sexes Eligible for Study:
Gender Based Eligibility:
Accepts Healthy Volunteers:
Poorly regulated hypothyroidism
Female aged between 18 and 65 years
Written informed consent obtained from the patient according to national regulations