Cantharone for the Treatment of Perenial Warts
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|ClinicalTrials.gov Identifier: NCT03625960|
Recruitment Status : Completed
First Posted : August 10, 2018
Last Update Posted : August 10, 2018
|Condition or disease||Intervention/treatment||Phase|
|Wart, Genital||Drug: Cantharidin Drug: Trichloroacetic Acid||Phase 4|
Warts are one of the most common sexually transmitted diseases. They are caused by the human papilloma virus (HPV) that causes cervical cancer. Warts can grow, obstruct labor, and spread. Patients presenting to the obgyn clinic with perenial warts were randomized to treatment with trichloroacetic acid (one of the many types of treatments) or to the treatment with cantharidine group. Cantharidine is a vesicant extracted from beetle bugs which painlessly causes a small blister to form and cures the patient from the HPV infection causing the wart . We compared cosmesis, scar formation, pain and number of treatments (visits) as well as effectiveness in both groups.
- Determine if cantharone is more effective than trichloroacetic acid (TCA) for removal of warts
- Compare pain levels (pain during application) for each method
- Compare patient satisfaction for each method
- Compare scar formation and cosmesis for each method
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||12 participants|
|Intervention Model:||Parallel Assignment|
|Intervention Model Description:||Patients will be randomized to receive either trichloroacetic acid or cantharidine treatment.|
|Masking Description:||Patients will be randomized to receive treatment with trichloroacetic acid or cantharidine.|
|Official Title:||Trichloroacetic Acid Versus Cantharone for the Treatment of Perenial Warts|
|Actual Study Start Date :||June 15, 2006|
|Actual Primary Completion Date :||June 15, 2007|
|Actual Study Completion Date :||July 15, 2007|
Experimental: Cantharidine group
Application of cantharidine to perenial warts
A thin film of cantharidin is applied to the surface of the wart and to 1 millimeter area surrounding the wart. After the film dries, it is covered with an occlusive dressing for 24 hours. The patient removes the area the next day and thoroughly washes the area with soap and water. Patients return to clinic a week later.
Active Comparator: trichloroacetic acid group
application of trichloroacetic acid to perenial warts
Drug: Trichloroacetic Acid
Trichloroacetic acid is applied to the surface of the wart with a wooden applicator and after drying the area is washed with soap and water in an hour.
- Pain on treatment [ Time Frame: at 30 minutes time point from application of treatment. ]Comparison of pain when treatment is applied. The patient is asked on a scale of 0-5 (with 5 being extreme pain, 4 being severe pain, 3 being moderate, 2 being mild, 1 being slight and zero being no pain, how do you rate your pain.
- Assessment of a patient's likelihood of using this method again as measured on a survey question [ Time Frame: 2 weeks from starting therapy ]A questionnaire given to the patient at the conclusion of the study and containing the question "on a scale from 1-5 (5 most likely) how likely are you to recommend this method to a friend or using it again yourself".
- Presence of scarring or skin discoloration [ Time Frame: 2 weeks from starting therapy ]At the time of wart eradication, the treatment area is examined for healing. The clinician rates cosmesis on a scale from 0-5 with 5-skin grows back perfectly, 4-slight discoloration, 3-thickened skin, 1-slight scarring and 0-scarring.