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Fatigability and Physical Performance: Effects of Resistance Training Variables Manipulation

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT03619070
Recruitment Status : Unknown
Verified August 2018 by Fábio Lera Orsatti, Universidade Federal do Triangulo Mineiro.
Recruitment status was:  Recruiting
First Posted : August 7, 2018
Last Update Posted : August 8, 2018
Sponsor:
Information provided by (Responsible Party):
Fábio Lera Orsatti, Universidade Federal do Triangulo Mineiro

Brief Summary:
This study evaluate whether resistance training variables modulate the fatigability (power-duration relationship) and physical performance in adults and older adults

Condition or disease Intervention/treatment Phase
Aging Other: Resistance training, LL Other: Resistance training, HL Other: Resistance training, HVHL Other: Control group, CG Not Applicable

Detailed Description:
The resistance training variables manipulation is utilized for maximize the results of resistance training. However it is unclear whether the resistance training variables manipulation modulates the fatigability (i.e. power-duration relationship) and whether this explains the improvement on physical performance (i.e. gait speed, sit-to-stand and timed up and go tests).

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Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 80 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Prevention
Official Title: Fatigability and Physical Performance: Effects of Resistance Training Variables Manipulation
Actual Study Start Date : May 20, 2018
Estimated Primary Completion Date : September 30, 2018
Estimated Study Completion Date : November 15, 2018

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Health Checkup

Arm Intervention/treatment
Experimental: Lower load resistance training (LL)
In the LL group, postmenopausal women will perform the resistance training with moderate volume (i.e. three sets per exercise performed until or close to failure) and low load (i.e. 30% of 1RM)
Other: Resistance training, LL
In LL, the postmenopausal women will be submitted to 12 weeks of Resistance training with moderate volume (i.e. three sets per exercise) and low load (i.e. 30% of one repetition maximum)

Experimental: Higher load resistance training (HL)
In the HL group, postmenopausal women will perform the resistance training with moderate volume (i.e. three sets per exercise performed until or close to failure) and high load (i.e. 80% of 1RM)
Other: Resistance training, HL
In HL, the postmenopausal women will be submitted to 12 weeks of Resistance training with moderate volume (i.e. three sets per exercise) and high load (i.e. 80% of one repetition maximum)

Experimental: Higher volume resistance training (HVHL)
In the HVHL group, postmenopausal women will perform the resistance training with high volume (i.e. six sets per exercise performed until or close to failure) and high load (i.e. 80% of 1RM)
Other: Resistance training, HVHL
In HVHL, the postmenopausal women will be submitted to 12 weeks of Resistance training with high volume (i.e. six sets per exercise) and hig load (i.e. 80% of one maximum repetition)

Control group, (CG)
In CG, the postmenopausal women group will not perform exercise
Other: Control group, CG
The CG groups do not will performed the exercise.




Primary Outcome Measures :
  1. Fatigability [ Time Frame: Changes in fatigability measure (e.g. baseline and after 12 weeks of intervention) ]
    The fatigability will be evaluate by 60 maximum voluntary isometric contractions (3 s contraction, 2 s rest) in knee extensors at 70 degree.


Secondary Outcome Measures :
  1. Physical Performance [ Time Frame: Changes in physical performance measure (e.g. baseline and after 12 weeks of intervention) ]
    The physical performance will be evaluate by gait speed tests (e.g. 10m walking at usual and fast pace, 400m walk at usual and fast pace).


Other Outcome Measures:
  1. Body composition [ Time Frame: Changes in body composition (e.g. baseline and after 12 weeks of intervention) ]
    The body composition will be evaluate by dual-energy X-ray absorptiometry (DXA).

  2. Muscle strength [ Time Frame: Changes in muscle strength (e.g. baseline and after 12 weeks of intervention) ]
    Muscle strength will be assess in all subjects, by the one-repetition maximum (1-RM) test, for dynamic exercises. The 1-RM is defined as the maximal weight that is lifted with proper body alignment and correct lifting technique.



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Ages Eligible for Study:   50 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Postmenopausal women (>12 months amenorrhea) with age above or equal 50 years old.
  • No hormone therapy or phytoestrogens

Exclusion Criteria:

  • No-drinker alcohol (no alcohol intake whatsoever in their diet);
  • Non- smokers;
  • Hypertensive with uncontrolled blood pressure values;
  • Diabetic with uncontrolled glycemia;
  • Presence of arthropathies;
  • Presence of myopathies;
  • Skeletal musculotendinous disorder.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03619070


Contacts
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Contact: Fabio L Orsatti, PhD +55343700-6634 fabiorsatti@gmail.com

Locations
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Brazil
Post-degree program in physical education Recruiting
Uberaba, MG - Minas Gerais, Brazil, 38061-500
Contact: Fabio L Orsatti    +55 34 3700-6634    fabiorsatti@gmail.com   
Sponsors and Collaborators
Universidade Federal do Triangulo Mineiro
Investigators
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Principal Investigator: Fabio L Orsatti, PhD Federal University of Triangulo Mineiro
Publications:

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Responsible Party: Fábio Lera Orsatti, Principal Investigator, Universidade Federal do Triangulo Mineiro
ClinicalTrials.gov Identifier: NCT03619070    
Other Study ID Numbers: 85052218.0.0000.5154
First Posted: August 7, 2018    Key Record Dates
Last Update Posted: August 8, 2018
Last Verified: August 2018
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Keywords provided by Fábio Lera Orsatti, Universidade Federal do Triangulo Mineiro:
Fatigability
Postmenopausal Woman
Resistance training
Physical performance
Older adults