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Neutrophil Lymphocyte Ratio and Platelet Lymphocyte Ratio in Rheumatoid Arthritis

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ClinicalTrials.gov Identifier: NCT03617250
Recruitment Status : Not yet recruiting
First Posted : August 6, 2018
Last Update Posted : July 12, 2019
Sponsor:
Information provided by (Responsible Party):
Noha Foad, Assiut University

Brief Summary:
Rheumatoid arthritis is an autoimmune disease characterized by synovial inflammation and joint destruction that follows a relapsing- remitting course.Disease activity assessment is important for rheumatoid arthritis management .Neutrophil lymphocyte ratio and platelet lymphocyte ratio are associated with inflammatory status and can be used to assess disease activity in rheumatoid arthritis

Condition or disease Intervention/treatment
Rheumatoid Arthritis Other: Disease Activity Score-28

  Show Detailed Description

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Study Type : Observational
Estimated Enrollment : 100 participants
Observational Model: Case-Control
Time Perspective: Prospective
Official Title: The Correlation Between Neutrophil Lymphocyte Ratio and Platelet Lymphocyte Ratio With Disease Activity in Rheumatoid Arthritis
Estimated Study Start Date : November 1, 2019
Estimated Primary Completion Date : June 1, 2020
Estimated Study Completion Date : September 1, 2020

Resource links provided by the National Library of Medicine


Group/Cohort Intervention/treatment
Active patients
50 rheumatoid patients with active disease according to Disease Activity Score-28
Other: Disease Activity Score-28
Assessment of neutrophil-lymphocyte ratio and platelet-lymphocyte ratio and their association with Disease Activity Score-28

patients with remission
50 patients with remission according to Disease Activity Score-28
Other: Disease Activity Score-28
Assessment of neutrophil-lymphocyte ratio and platelet-lymphocyte ratio and their association with Disease Activity Score-28




Primary Outcome Measures :
  1. Assessment of inflammation in rheumatoid arthritis [ Time Frame: Average one year ]
    By using Disease Activity Score-28 to classify patients into patients with active disease and patients with remission



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Ages Eligible for Study:   18 Years to 70 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
One hundred rheumatoid arthritis patients divided into two groups. The first group with active disease and the second group with disease remission. There are 50 healthy participants age and sex matched as control group.
Criteria

Inclusion Criteria

  • One hundred patients suffering from Rheumatoid arthritis .

Exclusion Criteria:

Patients with:

  • Diabetes mellitus, hypertension, acute or chronic renal failure, acute or Chronic liver disease obstructive lung disease, Coronary artery disease.
  • Hematologic disorders other than anemia or history of receiving blood transfusion during the past three months.
  • Acute or chronic infections.
  • Pregnancy or in the postpartum period.
  • History of allergic diseases or any malignant disease.
  • Patients with leucocytic count less than 4000 u/l

Publications:

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Responsible Party: Noha Foad, Principal Investigator, Assiut University
ClinicalTrials.gov Identifier: NCT03617250     History of Changes
Other Study ID Numbers: RHEUMA
First Posted: August 6, 2018    Key Record Dates
Last Update Posted: July 12, 2019
Last Verified: July 2018

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No

Additional relevant MeSH terms:
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Arthritis
Arthritis, Rheumatoid
Joint Diseases
Musculoskeletal Diseases
Rheumatic Diseases
Connective Tissue Diseases
Autoimmune Diseases
Immune System Diseases