Role of Frontal Cortex in the Pathophysiology of Gilles de la Tourette Syndrome (GTS) (TIC-EEG)
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|ClinicalTrials.gov Identifier: NCT03604510|
Recruitment Status : Recruiting
First Posted : July 27, 2018
Last Update Posted : February 26, 2019
Tourette's syndrome (TS) is a debilitating and severe syndrome whose pathophysiology remains unclear.
In order to precise the cortical regions involved in the generation of tics, investigators will realize an electroencephalogram (EEG) recording in the frontal cortex of TS patients in ecological conditions (EEG-holter). Activity changes will be correlated with event markers of tics and neurovegetative parameters. Statistical analyses will be compared between epochs of EEG recording with tics and without tics. The aim is to define the cortical regions involved in the genesis of tics in order to consider new targets for cortical stimulation.
|Condition or disease||Intervention/treatment||Phase|
|Tourette Syndrome||Procedure: Electroencephalographic recordings||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||15 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Primary Purpose:||Health Services Research|
|Official Title:||Role of Frontal Cortex in the Pathophysiology of Gilles de la Tourette Syndrome (GTS)|
|Actual Study Start Date :||February 2, 2018|
|Estimated Primary Completion Date :||February 2, 2020|
|Estimated Study Completion Date :||February 2, 2020|
Experimental: Electroencephalographic recordings
Procedure: Electroencephalographic recordings
24 hours of electroencephalographic recordings (EEG-Holter) of prefrontal activity of Tourette's syndrome (TS) patients in ecological conditions.
- Electroencephalogram (EEG) signal [ Time Frame: During 24 hours ]24 hours recording of encephalographic activity (EEG) in ecological conditions through Holter EEG.
- Tic occurence [ Time Frame: During 24 hours ]Occurence of tic recorded by the patient with a button press connected with a case and automatically recorded with an accelerometers for motor tics.
- Age [ Time Frame: Day 0 ]
- Gender [ Time Frame: Day 0 ]
- Disease duration [ Time Frame: Day 0 ]
- Neurovegetative marker of emotions : RR Interval [ Time Frame: During 24 hours ]Intervals between R waves (RR interval) from the electrocardiogram
- Neurovegetative marker of emotions : skin conductance [ Time Frame: During 24 hours ]Skin conductance registered with a Bracelet sensor
- MINI (Mini International Neuropsychiatric Interview) [ Time Frame: Day 0 ]
- Montgomery and Asberg Depression Rating Sacle (MADRS) Score [ Time Frame: Day 0 ]
- State Trait Anxiety Inventory (STAI A and B) [ Time Frame: Day 0 ]
- Global Assessment of Functioning Score (Global Assessment of Functioning Scale) [ Time Frame: Day 0 ]
- Yale Global Tic severity score (YGTS) [ Time Frame: Day 0 ]
- ADHD RS rating score (ADHD RS rating Scale) [ Time Frame: Day 0 ]
- Yale Brown Obsessive Compulsive Score (Y-BOCS Scale) [ Time Frame: Day 0 ]
- Obsessive-Compulsive Inventory-Revised Score (OCI-R) [ Time Frame: Day 0 ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03604510
|Contact: Antoine Daubigney||05 56 79 55 firstname.lastname@example.org|
|Contact: Clotilde Huet||05 57 82 09 email@example.com|
|CHU de Bordeaux||Recruiting|
|Bordeaux, France, 33 076|
|Contact: Antoine Daubigney 05 56 79 55 13 firstname.lastname@example.org|
|Contact: Clotilde Huet 05 57 82 09 54 email@example.com|