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Platinum-based Chemotherapy With Atezolizumab and Niraparib in Patients With Recurrent Ovarian Cancer (ANITA) (ANITA)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT03598270
Recruitment Status : Recruiting
First Posted : July 26, 2018
Last Update Posted : December 3, 2019
Sponsor:
Collaborators:
Hoffmann-La Roche
Tesaro, Inc.
AGO Study Group
Belgian Gynaecological Oncology Group
ARCAGY/ GINECO GROUP
The Israeli Society of Gynecologic Oncology
MaNGO
Information provided by (Responsible Party):
Grupo Español de Investigación en Cáncer de Ovario

Brief Summary:

Atezolizumab in this study is expected to have a positive benefit-risk profile for the treatment of patients with platinum-sensitive relapse of ovarian cancer. Of interest, atezolizumab is being investigated also in combination with platinum-based doublet chemotherapy in second line (2L)/ third line (3L) platinum-sensitive recurrent ovarian cancer patients in ATALANTE (NCT02891824), which also includes bevacizumab in the combination. The study is proceeding as expected after >100 patients enrolled and under independent Data Monitoring Committee (IDMC) supervision.

Platinum-containing therapy is considered the treatment of choice for patients with platinum-sensitive relapse. However the duration of response and the prolongation of the progression free interval with chemotherapy are usually brief, among other because these chemotherapy regimens cannot be continued until progression as they are associated with neurological, renal and hematological toxicity and cannot generally be tolerated for more than about 6 to 9 cycles.

Niraparib received FDA approval in March 2017 as maintenance treatment of adult patients with recurrent epithelial ovarian, fallopian tube or primary peritoneal cancer who are in complete or partial response to platinum-based chemotherapy. Recently, the European Medicines Agency (EMA) has also approved niraparib as maintenance monotherapy. Despite the progress brought about by niraparib, there is a need for a more effective treatment to extend the progression free interval in this patient population. The combination with immune checkpoint inhibitors such as anti-death protein 1 (anti-PD1) or anti-death protein ligand 1 (anti-PD-L1) has a compelling rationale to this aim, especially under the light of the emerging clinical data of this combination.

The use of atezolizumab concurrent to platinum-containing chemotherapy followed by niraparib as maintenance therapy after completion of chemotherapy, as per normal clinical practice, may provide further benefit to patients in terms of prolonging the progression free interval and increasing the interval between lines of chemotherapy, hence delaying further hospitalization and the cumulative toxicities associated with chemotherapy. Additionally, preliminary studies with atezolizumab suggest an acceptable tolerability profile for long term clinical use in recurrent ovarian cancer patients and other indications.


Condition or disease Intervention/treatment Phase
Recurrent Ovarian Carcinoma Drug: Placebo Drug: Carboplatin Drug: Paclitaxel Drug: Niraparib Drug: Gemcitabine Drug: Pegylated liposomal doxorubicin (PLD) Drug: Atezolizumab Phase 3

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Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 414 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Intervention Model Description: Randomized, double-blinded, multi-center study
Masking: Triple (Participant, Care Provider, Investigator)
Masking Description:

Atezolizumab and placebo treatment will be double blinded, unknown to both the subject and the study staff, including the treating physician. In order to maintain the blind, atezolizumab and placebo will be identical in appearance and packaging.

The study medication will be labeled using a unique kit id number, which is linked to the randomization scheme. The active and placebo kits will be presented in the same packaging to ensure blinding of the study medication Individual treatment codes, indicating the treatment randomization for each randomized patient, will be available to the investigator(s) or pharmacists from the IVRS/IWRS. Routines for this will be described in the Interactive Voice Response System/Interactive Web Response System (IVRS/IWRS) user manual that will be provided to each centre.

Primary Purpose: Treatment
Official Title: A Phase III Randomized, Double-blinded Trial of Platinum-based Chemotherapy With or Without Atezolizumab Followed by Niraparib Maintenance With or Without Atezolizumab in Patients With Recurrent Ovarian, Tubal or Peritoneal Cancer and Platinum Treatment-free Interval (TFIp) >6 Months
Actual Study Start Date : November 21, 2018
Estimated Primary Completion Date : May 2023
Estimated Study Completion Date : November 2023


Arm Intervention/treatment
Placebo Comparator: Arm A (Control Arm)

Placebo of atezolizumab in combination with one of the platinum based regimens below (investigator's choice) followed by maintenance niraparib with placebo:

  • Carboplatin plus paclitaxel and placebo every 3 weeks. Non-progressing patients will be switched to maintenance niraparib in combination with placebo every 3 weeks
  • Carboplatin plus gemcitabine and placebo every 3 weeks. Non-progressing patients will be switched to maintenance niraparib in combination with placebo every 3 weeks.
  • Carboplatin plus pegylated liposomal doxorubicin (PLD) and placebo every 4 weeks. Non-progressing patients will be switched to maintenance niraparib in combination with placebo every 3 weeks.
Drug: Placebo
Volume equivalent to 1200 mg of atezolizumab drug product. Intravenous Day 1
Other Name: Placebo of Atezolizumab

Drug: Carboplatin
Intravenous. Day 1

Drug: Paclitaxel
175 mg/m². Intravenous. Day 1

Drug: Niraparib
200 mg or 300 mg. Oral. From day 1 to 21

Drug: Gemcitabine
1000 mg/m². Intravenous. Day 1 and day 8.

Drug: Pegylated liposomal doxorubicin (PLD)
30 mg/m². Intravenous. Day 1

Experimental: Arm B (experimental arm)

Atezolizumab in combination with one of the platinum based regimens below (investigator's choice) followed by maintenance niraparib with atezolizumab:

  • Carboplatin plus paclitaxel and atezolizumab every 3 weeks. Non-progressing patients will be switched to maintenance niraparib in combination with atezolizumab every 3 weeks.
  • Carboplatin plus gemcitabine and atezolizumab every 3 weeks. Non-progressing patients will be switched to maintenance niraparib in combination with atezolizumab every 3 weeks.
  • Carboplatin plus pegylated liposomal doxorubicin (PLD) and atezolizumab every 4 weeks. Non-progressing patients will be switched to maintenance niraparib in combination with atezolizumab every 3 weeks.
Drug: Carboplatin
Intravenous. Day 1

Drug: Paclitaxel
175 mg/m². Intravenous. Day 1

Drug: Niraparib
200 mg or 300 mg. Oral. From day 1 to 21

Drug: Gemcitabine
1000 mg/m². Intravenous. Day 1 and day 8.

Drug: Pegylated liposomal doxorubicin (PLD)
30 mg/m². Intravenous. Day 1

Drug: Atezolizumab
1200 mg. Intravenous. Day 1
Other Name: Tecentriq




Primary Outcome Measures :
  1. Progression-free survival (PFS) [ Time Frame: 30 months ]
    Period from study entry (day of randomization) until disease progression, death or date of last contact. Progression will be based on tumor assessment made by the investigators according to the RECIST v1.1 criteria.


Secondary Outcome Measures :
  1. Overall survival (OS) [ Time Frame: 60 months ]
    The observed length of life from entry into the study (day of randomization) to death due to any cause, or the date of last contact if patient alive.

  2. Time to first subsequent therapy or death (TFST) [ Time Frame: 60 months ]
    Time from the date of randomization in the current study to the start date of the first subsequent anticancer therapy.

  3. Time to second subsequent therapy or death (TSST) [ Time Frame: 60 months ]
    Time from the date of randomization in the current study to the start date of the second subsequent anticancer therapy

  4. Time to second progression or death (PFS2) [ Time Frame: 60 months ]
    Time from treatment randomization to the earliest date of assessment of progression on the next anticancer therapy following study treatment or death by any cause.

  5. Incidence of Treatment Adverse Events [ Time Frame: 60 months ]
    Frequency and severity of adverse events as assessed by CTCAE version 4.03 for the regimens administered on this study

  6. Patient-reported abdominal symptoms [ Time Frame: 60 months ]
    Clinically-meaningful improvement in patient-reported abdominal pain or bloating, defined as a 10-point decrease from the baseline score on either of the two items of the EORTC quality of life questionnaire-ovarian cancer module (QLQ-OV28) abdominal/GI symptom scale (items 31 and 32)

  7. Patient-reported outcomes (PROs) of function and health related quality of life (HRQoL) [ Time Frame: 60 months ]
    Clinical improvement, remaining stable, or deterioration in patient-reported function and HRQoL, defined as a 10-point increase, changes within 10 points, and a 10-point decrease, respectively, from the baseline score on each of the functional (physical, role, emotional, and social) and global health status/HRQoL scales of EORTC QLQ-C30

  8. Objective Response Rate (ORR) [ Time Frame: 60 months ]
    Based on investigator assessment by RECIST v1.1 during the chemotherapy phase and during the maintenance phase

  9. Duration of response (DOR) [ Time Frame: 60 months ]
    Based on investigator assessment by RECIST v1.1 during the chemotherapy phase and during the maintenance phase

  10. Progression-free survival (PFS) from the beginning of the maintenance phase in all patients, in patients in complete or partial response after completing chemotherapy and in patients with stable disease after completing chemotherapy [ Time Frame: 60 months ]
    Period from start of maintenance treatment until disease progression, death or date of last contact assessed by the investigator according to RECIST v1.1 criteria, in all patients receiving maintenance treatment as well as in the subgroup of patients with complete response/partial response (CR/PR) of stable disease (SD) after completing chemotherapy

  11. Progression Free Survival (PFS) and BRCA status [ Time Frame: 60 months ]
    Relationship of PFS with BRCA mutational status

  12. Overall Survival (OS) and BRCA status [ Time Frame: 60 months ]
    Relationship of OS with BRCA mutational status

  13. Time to first subsequent therapy or death (TFST) and BRCA status [ Time Frame: 60 months ]
    Relationship of TFST with BRCA mutational status

  14. Objective Response Rate (ORR) and BRCA status [ Time Frame: 60 months ]
    Relationship of ORR with BRCA mutational status

  15. Duration of Response (DOR) and BRCA status [ Time Frame: 60 months ]
    Relationship of DOR with BRCA mutational status

  16. Characterize the pharmacokinetics (PK) of atezolizumab [ Time Frame: 60 months ]
    Serum concentration (Cmax) of atezolizumab

  17. Characterize the pharmacokinetics (PK) of atezolizumab [ Time Frame: 60 months ]
    Serum concentration (Cmin) of atezolizumab

  18. Determine the incidence of anti-therapeutic antibody (ATAs) [ Time Frame: 60 months ]
    Incidence of ATAs during the study relative to the prevalence of ATAs at baseline


Other Outcome Measures:
  1. Evaluate PROs of disease associated with atezolizumab versus placebo [ Time Frame: 60 months ]
    Mean and mean changes from the baseline score in disease by cycle and between treatment arms as assessed by scale of european organization for research and treatment of cancer quality of life questionnaire core-30 (EORTC QLQ-C30)

  2. Evaluate PROs of disease associated with atezolizumab versus placebo [ Time Frame: 60 months ]
    Mean and mean changes from the baseline score in disease by cycle and between treatment arms as assessed by scale quality of life questionnaire ovarian 28 (QLQ-OV28)

  3. Evaluate treatment-related symptoms associated with atezolizumab versus placebo [ Time Frame: 60 months ]
    Mean and mean changes from the baseline score in treatment-related symptoms by cycle and between treatment arms as assessed by all symptom item scale of EORTC QLQ-C30.

  4. Evaluate treatment-related symptoms associated with atezolizumab versus placebo [ Time Frame: 60 months ]
    Mean and mean changes from the baseline score in treatment-related symptoms by cycle and between treatment arms as assessed by all symptom item scale of EORTC QLQ-OV28

  5. Treatment burden [ Time Frame: 60 months ]
    Any treatment burden patients may experience in association with atezolizumab versus placebo, as measured by a single item (from GP5: "I am bothered by side effects of treatment") from the physical wellbeing subscale of the Functional Assessment of Cancer Therapy - General (FACT-G) Quality of Life instrument

  6. Patients' health utility [ Time Frame: 60 months ]
    Evaluate and compare between treatment arms patients' health utility as measured by European Quality of Life Visual Analogue Scale (EQ-VAS) to generate utility scores for use in economic models for reimbursement

  7. Patients' health utility [ Time Frame: 60 months ]
    Evaluate and compare between treatment arms patients' health utility as measured by EuroQoL 5 Dimension to generate utility scores for use in economic models for reimbursement

  8. Patients' health utility [ Time Frame: 60 months ]
    Evaluate and compare between treatment arms patients' health utility as measured by 5 Level Questionnaire (EQ-5D-5L) to generate utility scores for use in economic models for reimbursement

  9. Association of PD-L1 expression and other immune biomarkers with clinical outcomes [ Time Frame: 60 months ]
    Relationship between tumour immune-related or disease type-related biomarkers (including but not limited to mutational burden, PD-L1, tumor-infiltrating lymphocytes (TILs) and cluster of differentiation (CD)8) in tumour tissues or blood samples, and clinical outcomes

  10. Biomarkers predictive of the response to atezolizumab. [ Time Frame: 60 months ]
    Relationship between exploratory biomarkers (circulating cell-free DNA) assessed from plasma before and during/after treatment, and clinical outcomes

  11. Biomarkers predictive of the response to atezolizumab. [ Time Frame: 60 months ]
    Relationship between exploratory biomarkers (proteins) assessed from plasma before and during/after treatment, and clinical outcomes

  12. Biomarkers predictive of the response to atezolizumab. [ Time Frame: 60 months ]
    Relationship between exploratory biomarkers (cytokines) assessed from plasma before and during/after treatment, and clinical outcomes

  13. Effect of antibiotic (ATB) use on the efficacy of atezolizumab. [ Time Frame: 60 months ]
    Relationship between ATB use within 2 month before and 1 month after the first study administration with atezolizumab efficacy as measured by PFS.

  14. To evaluate the efficacy of atezolizumab vs placebo according to previous use of PARP inhibitors in front line. [ Time Frame: 60 months ]
    Relationship between previous use of PARP inhibitors in front line and clinical outcomes.



Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   Female
Gender Based Eligibility:   Yes
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  1. Patients ≥ 18 years old
  2. Life expectancy ≥3 months
  3. Signed informed consent and ability to comply with treatment and follow-up
  4. Histologically confirmed diagnosis (cytology alone excluded) of high- grade serous or endometrioid ovarian, primary peritoneal or tubal carcinoma.
  5. BReast CAncer (BRCA) mutational status is known (germline or somatic)
  6. Relapsed disease more than 6 months after the last platinum dose
  7. No more than 2 prior lines of chemotherapy are allowed, and the last one must contain a platinum-based regimen
  8. At least one measurable lesion to assess response by RECIST v1.1 criteria.
  9. Archival tumor sample must be available. In the absence of an archival biopsy, a tumour tissue biopsy will need to be collected prior to study enrolment.
  10. Performance status determined by Eastern Cooperative Oncology Group (ECOG) score of 0-1
  11. Normal organ and bone marrow function:

    • Haemoglobin ≥10.0 g/dL
    • Absolute neutrophil count (ANC) ≥1.5 x 109/L
    • Lymphocyte count ≥0.5 × 109/L
    • Platelet count ≥100 x 109/L
    • Total bilirubin ≤1.5 x institutional upper limit of normal (ULN)
    • Serum albumin ≥2.5 g/dL
    • Aspartate aminotransferase (AST) and Alanine aminotransferase (ALT) ≤2.5 x ULN, unless liver metastases are present in which case they must be ≤5 x ULN
    • Serum creatinine ≤1.5 x institutional ULN or calculated creatinine clearance ≥ 30 mL/min using the Cockcroft-Gault equation
    • Patients not receiving anticoagulant medication must have an International Normalized Ratio (INR) ≤1.5 and an Activated ProThrombin Time (aPTT) ≤1.5 x ULN.
  12. Negative Test Results for Hepatitis.
  13. Toxicities related to previous treatments must be recovered to < grade 2
  14. Female participants must be postmenopausal or surgically sterile or otherwise have a negative serum pregnancy test within 7 days of the first study treatment and agree to abstain from heterosexual intercourse or use single or combined contraceptive methods.
  15. Participant must agree to not donate blood during the study or for 90 days after the last dose of study treatment.
  16. Participant must agree to not breastfeed during the study or for 180 days after the last dose of study treatment.

Exclusion Criteria:

  1. Non-epithelial tumor of the ovary, the fallopian tube or the peritoneum.
  2. Ovarian tumors of low malignant potential or low grade
  3. Other malignancy within the last 5 years except curatively treated non-melanoma skin cancer, in situ cancer of the cervix and ductal carcinoma in situ (DCIS)
  4. Major surgery within 4 weeks of starting study treatment or patients who have not completely recovered (Grade ≥ 2) from the effects of any major surgery at randomization
  5. Core biopsy or other minor surgical procedure, excluding placement of a vascular access device, within 7 days prior to Day 1, Cycle 1
  6. Administration of other chemotherapy drugs, anticancer therapy or anti-neoplastic hormonal therapy, or treatment with other investigational agents or devices within 28 days prior to randomization, or within a time interval less than at least 5 half-lives of the investigational agent, whichever is shorter, or anticipation to do it during the trial treatment period (non-investigational hormonal replacement therapy is permitted)
  7. Palliative radiotherapy (e.g., for pain or bleeding) within 6 weeks prior to randomization or patients who have not completely recovered (Grade ≥ 2) from the effects of previous radiotherapy
  8. Current or recent (within 10 days prior to randomization) chronic use of aspirin (>325 mg/day) or clopidogrel (>75 mg/day)
  9. Clinically significant (e.g. active) cardiovascular disease
  10. Resting ECG with corrected QT interval (QTc) >470 msec on 2 or more time points within a 24 hour period or family history of long QT syndrome
  11. Left ventricular ejection fraction defined by multigated acquisition/echocardiogram (MUGA/ECHO) below the institutional lower limit of normal (only applicable for patients intended to be treated with pegylated liposomal doxorubicin)
  12. History or clinical suspicion of brain metastases or spinal cord compression. CT/MRI of the brain is mandatory (within 4 weeks prior to randomization) in case of suspected brain metastases. Spinal MRI is mandatory (within 4 weeks prior to randomization) in case of suspected spinal cord compression
  13. History or evidence upon neurological examination of central nervous system (CNS) disorders (e.g. uncontrolled epileptic seizures) unless adequately treated with standard medical therapy
  14. Current, clinically relevant bowel obstruction, including sub-occlusive disease, related to underlying disease
  15. Uncontrolled tumor-related pain
  16. Uncontrolled pleural effusion, pericardial effusion, or ascites requiring recurrent drainage procedures (once monthly or more frequently). Patients with indwelling catheters (e.g., PleurX) are allowed
  17. Uncontrolled hypercalcemia (>1.5 mmol/L ionized calcium or calcium >12 mg/dL or corrected serum calcium > ULN) or symptomatic hypercalcemia requiring continued use of bisphosphonate therapy or denosumab
  18. Evidence of any other disease, metabolic dysfunction, physical examination finding or laboratory finding giving reasonable suspicion of a disease or condition that contraindicates the use of an investigational drug or puts the patient at high risk for treatment related complications
  19. Pregnant or lactating women
  20. Simultaneously receiving therapy in any interventional clinical trial
  21. Prior treatment with CD137 agonists or immune checkpoint stimulating or blockade therapies, such as anti-PD1, anti-PDL1 or anti-CTLA4 therapeutic antibodies
  22. Treatment with systemic immunostimulatory agents (including but not limited to interferon-alpha (IFN-α) and interleukin-2 (IL-2) within 4 weeks or five half-lives of the drug (whichever is shorter) prior to Cycle 1, Day 1
  23. Treatment with systemic corticosteroids or other systemic immunosuppressive medications (including but not limited to prednisone, dexamethasone, cyclophosphamide, azathioprine, methotrexate, thalidomide, and anti-tumor necrosis factor (TNF) agents) within 2 weeks prior to Cycle 1, Day 1, or anticipated requirement for systemic immunosuppressive medications during the trial
  24. History of autoimmune disease, including but not limited to myasthenia gravis, myositis, autoimmune hepatitis, systemic lupus erythematosus, rheumatoid arthritis, inflammatory bowel disease, vascular thrombosis associated with anti-phospholipid syndrome, Wegener's granulomatosis, Sjögren's syndrome, Guillain-Barré syndrome, multiple sclerosis, vasculitis, or glomerulonephritis
  25. History of idiopathic pulmonary fibrosis (including pneumonitis), drug-induced pneumonitis, organizing pneumonia (i.e., bronchiolitis obliterans, cryptogenic organizing pneumonia), or evidence of active pneumonitis
  26. Immunocompromised patients, e.g., patients who are known to be serologically positive for human immunodeficiency virus (HIV)
  27. Signs or symptoms of infection within 2 weeks prior to Cycle 1, Day 1
  28. Active tuberculosis
  29. Administration of a live, attenuated vaccine (including against influenza) within 4 weeks prior to Cycle 1, Day 1 or anticipation that it will be administered at any time during the treatment period of the study
  30. History of severe allergic, anaphylactic, or other hypersensitivity reactions to chimeric or humanized antibodies or fusion proteins
  31. Known hypersensitivity or allergy to biopharmaceuticals produced in Chinese hamster ovary cells or to any component of the atezolizumab formulation or allergy to any of the other drugs included in the protocol or their solvents (including to Cremophor®)
  32. Patient has received prior treatment with a poly (adenosine diphosphate (ADP)-ribose) polymerase (PARP) inhibitor in the recurrent setting or has participated in a study where any treatment arm included administration of a PARP inhibitor in the recurrent setting, unless the patient is unblinded and there is evidence of not having received a PARP inhibitor
  33. Patient has had any known ≥Grade 3 hematological toxicity anemia, neutropenia or thrombocytopenia due to prior cancer chemotherapy that persisted >4 weeks and was related to the most recent treatment
  34. Patient has any known history or current diagnosis of Myelodysplasic syndrome (MDS) or Anaplastic Myeloid Leukemia (AML)
  35. Previous allogeneic bone marrow transplant or previous solid organ transplantation
  36. Patient has a condition (such as transfusion dependent anemia or thrombocytopenia), therapy, or laboratory abnormality that might confound the study results or interfere with the patient's participation for the full duration of the study treatment
  37. Participant has any known hypersensitivity to niraparib components or excipients

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03598270


Contacts
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Contact: Javier Sanchez, MBA MSc +34 669 528 261 jsanchez@grupogeico.net
Contact: Carmen Marqués, MD cmarques@grupogeico.net

Locations
Show Show 58 study locations
Sponsors and Collaborators
Grupo Español de Investigación en Cáncer de Ovario
Hoffmann-La Roche
Tesaro, Inc.
AGO Study Group
Belgian Gynaecological Oncology Group
ARCAGY/ GINECO GROUP
The Israeli Society of Gynecologic Oncology
MaNGO
Investigators
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Principal Investigator: Antonio Gonzalez, MD PhD Clinica Universitaria de Navarra
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Responsible Party: Grupo Español de Investigación en Cáncer de Ovario
ClinicalTrials.gov Identifier: NCT03598270    
Other Study ID Numbers: ENGOT-Ov41/GEICO 69-O/ANITA
2018-000366-11 ( EudraCT Number )
ENGOT-Ov41 ( Other Identifier: ENGOT )
GEICO 69-O ( Other Identifier: GEICO )
First Posted: July 26, 2018    Key Record Dates
Last Update Posted: December 3, 2019
Last Verified: November 2019

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Keywords provided by Grupo Español de Investigación en Cáncer de Ovario:
Ovarian
Atezolizumab
Niraparib
Additional relevant MeSH terms:
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Ovarian Neoplasms
Carcinoma, Ovarian Epithelial
Endocrine Gland Neoplasms
Neoplasms by Site
Neoplasms
Ovarian Diseases
Adnexal Diseases
Genital Neoplasms, Female
Urogenital Neoplasms
Endocrine System Diseases
Gonadal Disorders
Carcinoma
Neoplasms, Glandular and Epithelial
Neoplasms by Histologic Type
Gemcitabine
Paclitaxel
Carboplatin
Doxorubicin
Liposomal doxorubicin
Atezolizumab
Niraparib
Antibodies, Monoclonal
Antineoplastic Agents, Phytogenic
Antineoplastic Agents
Tubulin Modulators
Antimitotic Agents
Mitosis Modulators
Molecular Mechanisms of Pharmacological Action
Antimetabolites, Antineoplastic
Antimetabolites