Objective Assessment of Sensory Nerve Fiber Sensitivity
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This pilot study utilizes a unique technology to determine nerve fiber sensitivity. This will allow us to determine whether this method and device can discern changes in pain intensity and type, which is predicated on differing nerve fiber sensitivities.
Pupillary Reflex Parameters [ Time Frame: 0,5,10,15,20,25,30,35 minutes ]
The primary measurable endpoint is the change in the Area Under the Curve (AUC) of the three sensory nerve fiber types that occurs as a response to tourniquet ischemia and reperfusion. The change is calculated by the difference between measurements at various time points: baseline, tourniquet application, and tourniquet release.
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Layout table for eligibility information
Ages Eligible for Study:
18 Years to 65 Years (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Healthy Adult Volunteers will be from within the Children's National Medical Center and the surrounding community.
The subject is 18 to 65 years of age
The subject is willing to have a tourniquet applied as part of the study
The subject is willing and able to provide written informed consent to the study participation
The subject is willing and able to comply with all study procedures
Eye pathology precluding pupillometry
Subjects who have ongoing pain requiring medical attention