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Trial record 17 of 579 for:    meningitis

Meningitis With Cerebral Vasculitis in Children

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ClinicalTrials.gov Identifier: NCT03595761
Recruitment Status : Completed
First Posted : July 23, 2018
Last Update Posted : July 25, 2018
Sponsor:
Information provided by (Responsible Party):
University Hospital, Montpellier

Brief Summary:

Purulent meningitis are life-threatening diseases in childhood. Cerebral vasculitis have been described in bacterial meningitis, but poor is known about their physiology and their impact on outcome.

The investigators decide to realize a retrospective mono-centric study carried out at Montpellier university hospital which looks back at a 7-year study(2009-2016).

The Investigators selected purulent meningitis cases based on the bacteriological data provided by the HDB (hospital data base). The Investigators divides in two groups : Group A if patients present a cerebral vasculitis ( radiologic diagnostic by RMI or tomodensitometry), in all, cases the diagnosis of vasculitis was confirmed by a radiologist specialised in neuropaediatrics by a second reading;Group B purulent meningitis with a cerebral vasculitis imaging.

Tuberculous meningitis, meningitis in CSF shunt, and in patients having chemotherapy were excluded.

The investigators report clinical and biological finding, inflammatory marker at the onset. The Investigators register also the clinical evolution and sequelae


Condition or disease
Bacterial Meningitis

Detailed Description:

Meningitis steel are a cause of death in childhood. Cerebral complication are often responsable of poor prognosis. One of these complication vasculitis is steel not weel understood. There are only few study about it on children.

It is a retrospective study about 17 cases of chil which bacterial meningitis coupled wiethe cerebral vasculitis, the Investigators will describe epidemiology, bacteriology, evolution and corticosteroid treatment in this patients.


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Study Type : Observational
Actual Enrollment : 17 participants
Observational Model: Cohort
Time Perspective: Retrospective
Official Title: Retrospective Study About 17 Cases of Child With Bacterial Meningitis Coupled With Cerebral Vasculitis
Actual Study Start Date : June 1, 2017
Actual Primary Completion Date : August 1, 2017
Actual Study Completion Date : August 31, 2017

Resource links provided by the National Library of Medicine





Primary Outcome Measures :
  1. Found a difference demographic data [ Time Frame: 1 day ]
    Found a difference demographic data between population A and B (age)

  2. Found a difference demographic data [ Time Frame: 1 day ]
    Found a difference demographic data between population A and B (gender)

  3. Found a difference Clinical manifestation [ Time Frame: 1 day ]
    Found a difference Clinical manifestation between population A and B

  4. Found a difference Inflammatory parkers [ Time Frame: 1 day ]
    Found a difference Inflammatory parkers between population A and B

  5. Found a difference Infectious agent [ Time Frame: 1 day ]
    Found a difference Infectious agent between population A and B


Secondary Outcome Measures :
  1. Found a difference in the evolution of the diseases between group A and B [ Time Frame: 1 day ]
    The data analysed will be : presence of seizure within the next 6 month before the last survey, necessity of antiepileptic treatment, development delay, presence of neurologic deficiency(palsy), persistence of abnormality on neuroimaging.

  2. In the A group, studying the relationship between prescription of steroids pulse and final outcome and presence of sequelae. [ Time Frame: 1 day ]
    Sequelae will be defined by the presence of one of this element : : presence of seizure within the next 6 month before the last survey, necessity of antiepileptic treatment, development delay, presence of neurologic deficiency(palsy), persistence of abnormality on neuroimaging.



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Ages Eligible for Study:   up to 18 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Children with bacterial meningitis, and cerrbal vasculitis
Criteria

Inclusion Criteria:

  • bacterial meningitis with LCR confirmation

Exclusion criteria:

  • tuberculous meningitis, immunosuppressor treatment, material like DVP

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03595761


Locations
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France
Uhmontpellier
Montpellier, France, 34290
Sponsors and Collaborators
University Hospital, Montpellier
Investigators
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Study Director: Eric JEZIORSKI UH

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Responsible Party: University Hospital, Montpellier
ClinicalTrials.gov Identifier: NCT03595761     History of Changes
Other Study ID Numbers: RECHMPL17_0193
First Posted: July 23, 2018    Key Record Dates
Last Update Posted: July 25, 2018
Last Verified: July 2017
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: Undecided
Plan Description: NC

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No

Keywords provided by University Hospital, Montpellier:
cerebral vasculitis

Additional relevant MeSH terms:
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Meningitis
Meningitis, Bacterial
Vasculitis
Vasculitis, Central Nervous System
Central Nervous System Diseases
Nervous System Diseases
Vascular Diseases
Cardiovascular Diseases
Central Nervous System Bacterial Infections
Bacterial Infections
Central Nervous System Infections
Autoimmune Diseases of the Nervous System
Cerebrovascular Disorders
Brain Diseases
Autoimmune Diseases
Immune System Diseases