Meningitis With Cerebral Vasculitis in Children
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|ClinicalTrials.gov Identifier: NCT03595761|
Recruitment Status : Completed
First Posted : July 23, 2018
Last Update Posted : July 25, 2018
Purulent meningitis are life-threatening diseases in childhood. Cerebral vasculitis have been described in bacterial meningitis, but poor is known about their physiology and their impact on outcome.
The investigators decide to realize a retrospective mono-centric study carried out at Montpellier university hospital which looks back at a 7-year study(2009-2016).
The Investigators selected purulent meningitis cases based on the bacteriological data provided by the HDB (hospital data base). The Investigators divides in two groups : Group A if patients present a cerebral vasculitis ( radiologic diagnostic by RMI or tomodensitometry), in all, cases the diagnosis of vasculitis was confirmed by a radiologist specialised in neuropaediatrics by a second reading;Group B purulent meningitis with a cerebral vasculitis imaging.
Tuberculous meningitis, meningitis in CSF shunt, and in patients having chemotherapy were excluded.
The investigators report clinical and biological finding, inflammatory marker at the onset. The Investigators register also the clinical evolution and sequelae
|Condition or disease|
Meningitis steel are a cause of death in childhood. Cerebral complication are often responsable of poor prognosis. One of these complication vasculitis is steel not weel understood. There are only few study about it on children.
It is a retrospective study about 17 cases of chil which bacterial meningitis coupled wiethe cerebral vasculitis, the Investigators will describe epidemiology, bacteriology, evolution and corticosteroid treatment in this patients.
|Study Type :||Observational|
|Actual Enrollment :||17 participants|
|Official Title:||Retrospective Study About 17 Cases of Child With Bacterial Meningitis Coupled With Cerebral Vasculitis|
|Actual Study Start Date :||June 1, 2017|
|Actual Primary Completion Date :||August 1, 2017|
|Actual Study Completion Date :||August 31, 2017|
- Found a difference demographic data [ Time Frame: 1 day ]Found a difference demographic data between population A and B (age)
- Found a difference demographic data [ Time Frame: 1 day ]Found a difference demographic data between population A and B (gender)
- Found a difference Clinical manifestation [ Time Frame: 1 day ]Found a difference Clinical manifestation between population A and B
- Found a difference Inflammatory parkers [ Time Frame: 1 day ]Found a difference Inflammatory parkers between population A and B
- Found a difference Infectious agent [ Time Frame: 1 day ]Found a difference Infectious agent between population A and B
- Found a difference in the evolution of the diseases between group A and B [ Time Frame: 1 day ]The data analysed will be : presence of seizure within the next 6 month before the last survey, necessity of antiepileptic treatment, development delay, presence of neurologic deficiency(palsy), persistence of abnormality on neuroimaging.
- In the A group, studying the relationship between prescription of steroids pulse and final outcome and presence of sequelae. [ Time Frame: 1 day ]Sequelae will be defined by the presence of one of this element : : presence of seizure within the next 6 month before the last survey, necessity of antiepileptic treatment, development delay, presence of neurologic deficiency(palsy), persistence of abnormality on neuroimaging.
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Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03595761
|Montpellier, France, 34290|
|Study Director:||Eric JEZIORSKI||UH|