Optical Coherence Tomography Examination in Acute Myocardial Infarction (OCTAMI)
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|ClinicalTrials.gov Identifier: NCT03593928|
Recruitment Status : Recruiting
First Posted : July 20, 2018
Last Update Posted : May 16, 2019
|Condition or disease|
|Myocardial Infarction Optical Coherence Tomography|
Acute myocardial infarction (AMI), which results from coronary artery occlusion due to thrombosis, remains the leading cause of death and disability worldwide. Pathological studies have demonstrated that plaque rupture accompanied by subsequent thrombus formation is the main mechanism responsible for AMI, accounting for approximately two thirds of cases; the remaining approximately one third of cases are the result of plaque erosion. Moreover, previous studies showed that the risk of cardiovascular events is significantly higher in patients with plaque rupture compared to those with plaque erosion. The EROSION study suggested that in patients with acute coronary syndrome presenting with plaque erosion, conservative treatment with anti-thrombotic therapy may be a reasonable option instead of stents implantation. Therefore, it is important to differentiate between the culprit morphologies in order to perform an accurate risk stratification and determine a personalized treatment strategy with the goal to improve the prognosis of patients with AMI.
Optical coherence tomography (OCT), a newly developed high resolution near infrared light-based intravascular imaging modality, can visualize the microstructure of atherosclerotic plaques such as the fibrotic cap, lipid pool, thrombi, and so on, and has been considered as the golden standard for differentiating plaque morphology in vivo.
In this study, we aimed to find risk factors and biomarkers for culprit lesion morphology as assessed by OCT.
|Study Type :||Observational|
|Estimated Enrollment :||400 participants|
|Official Title:||Pre-intervention and Post-intervention Optical Coherence Tomography Examination for Culprit Lesion in Patients With ST-segment Elevation Myocardial Infarction|
|Actual Study Start Date :||March 29, 2017|
|Estimated Primary Completion Date :||March 29, 2020|
|Estimated Study Completion Date :||April 29, 2020|
- culprit lesion morphology as assessed by OCT [ Time Frame: 1 day (pre-intervention OCT examination of culprit lesion) ]plaque rupture, plaque erosion or calcified nodule
Biospecimen Retention: Samples With DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03593928
|Contact: Hongbing Yan, MDemail@example.com|
|Contact: Yu Tan, PhDfirstname.lastname@example.org|
|Chinese Academy of Medical Sciences, Fuwai Hospital||Recruiting|
|Beijing, Beijing, China, 100037|
|Contact: Hongbing Yan, MD (0086)10+88322281 email@example.com|
|Contact: Yu Tan, PhD (0086)10+88322287 firstname.lastname@example.org|
|Principal Investigator:||Hongbing Yan, MD||Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences|