Periodic Limb Movement and Genetic Generalized Epilepsy (Epilepsy)
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|ClinicalTrials.gov Identifier: NCT03587506|
Recruitment Status : Completed
First Posted : July 16, 2018
Last Update Posted : July 16, 2018
|Condition or disease|
|Epilepsy Generalized Idiopathic Not Intractable|
Although periodic limb movements are prevalent among patients with epilepsy, the exact relationship between these movements and epilepsy remains elusive. Objective: The aim of this work was to study the periodic limb movements among patients with genetic generalized epilepsy in relation to different clinical characteristics and seizure recurrence. Methods: Sixty individuals participated in this study: thirty of them were newly diagnosed with genetic generalized epilepsy and thirty were healthy individuals. Sleep quality was assessed using the Pittsburgh Sleep Quality Index questionnaire, and a standard polysomnographic study was conducted to all subjects. All patients then received sodium valproate in therapeutic doses and were followed up for six months. Electroencephalogram (EEG) was done after the follow-up period and seizure recurrence was assessed. Accordingly, patients were classified into three groups according to clinical seizure recurrence and follow-up EEG findings.
Periodic limb movement index and frequency were compared among the patients' groups and were correlated with different clinical characteristics.
|Study Type :||Observational|
|Actual Enrollment :||60 participants|
|Official Title:||The Relationship Between Periodic Limb Movement and Seizure Recurrence in Genetic Generalized Epilepsy|
|Actual Study Start Date :||September 3, 2015|
|Actual Primary Completion Date :||September 2016|
|Actual Study Completion Date :||December 2016|
Group I (n=10) included patients who did not develop any major or minor seizure during the follow-up period and their follow up EEG was free of any epileptiform discharge
Patients: group II
Group II (n=11) included patients who developed only minor seizures and their follow up EEG showed epileptiform discharge
Patients: group III
Group III (n=9) were patients who developed one or more major seizures during the follow-up period whatever their EEG findings.
healthy volunteers (n=30) who were not related to the patients and had no family history of epilepsy.
- Seizure recurrence [ Time Frame: 6 months ]Clinical major or minor seizure, and electrical seizure