Effects of PS128 on Parkinsonian Symptoms
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT03566589|
Recruitment Status : Completed
First Posted : June 25, 2018
Last Update Posted : April 10, 2020
|Condition or disease||Intervention/treatment||Phase|
|Parkinson Disease||Dietary Supplement: Lactobacillus plantarum PS128||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||30 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Official Title:||Effects of Lactobacillus Plantarum PS128 on the Parkinsonian Symptoms in Parkinson's Disease: a Pilot Study|
|Actual Study Start Date :||July 2, 2018|
|Actual Primary Completion Date :||November 9, 2018|
|Actual Study Completion Date :||December 30, 2018|
daily ingestion of Lactobacillus plantarum PS128 capsules
Dietary Supplement: Lactobacillus plantarum PS128
daily ingestion of 60 billion colony forming unit (CFU) of Lactobacillus plantarum PS128 (30 billion CFU/capsule)
Other Name: PS128
- Change in Unified Parkinson's Disease Rating Scale (UPDRS) Score From Baseline to Change in Unified Parkinson's Disease Rating Scale (UPDRS) (Part III) Motor Score From Baseline to Week 12 Assessed On Medication [ Time Frame: Baseline to Week 12 ]The UPDRS scores is a rating tool used to gauge the course of Parkinson's disease in patients. The minimum total score possible is 0 and the maximum total score possible is 199. Higher values represent a worse outcome.
- Change in Nonmotor Symptoms: 30-item Screening Questionnaire (NMS-Quest) Score From Baseline to Week 12 Assessed On Medication [ Time Frame: to Week 12 Assessed On Medication ]NMS-Quest is a 30-item Screening tool for non-motor symptoms of Parkinson's disease. The minimum total score possible is 0 and the maximum total score possible is 30. Higher values represent a worse outcome.
- Change in Patient Global Impression of Change (PGIC) Score From Baseline to Week 12 Assessed On Medication [ Time Frame: to Week 12 Assessed On Medication ]The PGIC consists of one item taken from the clinical global impression and adapted to the patient. The minimum total score possible is 1 and the maximum total score possible is 7. Higher values represent a worse outcome.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03566589
|Professor Lu Neurological Clinic|
|Taoyuan City, Guishan Dist., Taiwan, 333|