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Trial record 1 of 212 for:    differential ventilation
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Differential Lung Ventilation vs. CPAP

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ClinicalTrials.gov Identifier: NCT03563612
Recruitment Status : Completed
First Posted : June 20, 2018
Last Update Posted : June 20, 2018
Sponsor:
Information provided by (Responsible Party):
Dr Michal Barak, Rambam Health Care Campus

Brief Summary:
In this study we compared the efficacy of continuous positive airway pressure (CPAP) to differential lung ventilation, in terms of patient's oxygenation, during video assisted thoracoscopic lung resection.

Condition or disease Intervention/treatment Phase
One Lung Ventilation Continuous Positive Airway Pressure Differential Lung Ventilation Device: cpap Not Applicable

Detailed Description:

Background: One Lung Ventilation (OLV) is the technique used during lung resection surgery in order to facilitate optimal surgical conditions. OLV may result in hypoxemia due to the shunt created. Several techniques are used to overcome the hypoxemia, one of which is continuous positive airway pressure (CPAP) to the non-dependent lung. Another technique is ventilating the non-dependent lung with a minimal volume, thus creating differential lung ventilation (DLV). In this study we compared the efficacy of CPAP to DLV during video assisted thoracoscopic lung resection.

Patients and Method: This is a prospective study of 30 adult patients undergoing elective video assisted thoracoscopic lung lobectomy. Each patient was ventilated in four modes: two lung ventilation, OLV, OLV+CPAP and OLV+DLV. Fifteen patients were ventilated with CPAP first and DLV next, and the other 15 were ventilated with DLV first and then CPAP. Five minutes separated each mode, during which the non-dependent lung was open to room air. We measured the patient's arterial blood gas during each mode of ventilation. The surgeons, who were blinded to the ventilation technique, were asked to assess the surgical conditions at each stage.

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 29 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Intervention Model Description: prospective randomized controlled crossover study
Masking: Double (Participant, Outcomes Assessor)
Primary Purpose: Treatment
Official Title: Differential Lung Ventilation vs. CPAP During One Lung Ventilation for Video Assisted Lung Surgery
Actual Study Start Date : April 1, 2017
Actual Primary Completion Date : September 30, 2017
Actual Study Completion Date : September 30, 2017

Arm Intervention/treatment
Active Comparator: cpap first, differential ventilation later Device: cpap
application of cpap to the non-dependent lung, during one lung ventilation

Active Comparator: differential ventilation first, cpap late Device: cpap
application of cpap to the non-dependent lung, during one lung ventilation




Primary Outcome Measures :
  1. arterial blood oxygenation [ Time Frame: intraoperative ]
    PaO2


Secondary Outcome Measures :
  1. interference with surgical field exposure [ Time Frame: intraoperative ]
    interference

  2. airway pressure in the dependent lung during one lung ventilation [ Time Frame: intraoperative ]
    airway pressure



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Ages Eligible for Study:   18 Years to 80 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  1. Adult patients diagnised with lung cancer
  2. Scheduled to have thoracoscopic lung lobectomy -

Exclusion Criteria:

  1. Pregnancy
  2. ASA>=4
  3. Difficult intubation -

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03563612


Locations
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Israel
Rambam Health Care Campus
Haifa, Israel
Sponsors and Collaborators
Rambam Health Care Campus
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
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Responsible Party: Dr Michal Barak, Senior Anesthesiologist, Rambam Health Care Campus
ClinicalTrials.gov Identifier: NCT03563612    
Other Study ID Numbers: RMB-0032-16
First Posted: June 20, 2018    Key Record Dates
Last Update Posted: June 20, 2018
Last Verified: June 2018

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Keywords provided by Dr Michal Barak, Rambam Health Care Campus:
one lung ventilation
continuous positive airway pressure
differential lung ventilation