Systemic Inflammatory Response: Thiamine and Magnesium Status (Sir TaM Study) (SirTaM)
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|ClinicalTrials.gov Identifier: NCT03554668|
Recruitment Status : Recruiting
First Posted : June 13, 2018
Last Update Posted : June 13, 2018
We wish to determine to what extent magnesium, thiamine and transketolase activity are affected by the Systemic Inflammatory Response (SIR). The knee arthroplasty model affords the ideal study design, as surgery generates an inflammatory response.
Blood samples are drawn preoperatively and for up to four days post operatively, and again at three months post-operation.
|Condition or disease||Intervention/treatment|
|Inflammation Magnesium Deficiency Iron-deficiency Thiamine Deficiency||Diagnostic Test: Blood draw|
Show Detailed Description
|Study Type :||Observational|
|Estimated Enrollment :||40 participants|
|Official Title:||The Relation Between Acute Changes in the Systemic Inflammatory Response, Thiamine and Magnesium Concentrations and Transketolase Activity After Elective Knee Arthroplasty.|
|Actual Study Start Date :||January 15, 2018|
|Estimated Primary Completion Date :||February 1, 2019|
|Estimated Study Completion Date :||June 1, 2019|
Post total knee replacement patients
Diagnostic Test: Blood draw
We take blood samples at pre-op and subsequent time points, up to three months post op.
- serum magnesium [ Time Frame: three months ]blood sample
- thiamine [ Time Frame: three months ]blood sample
- erythrocyte transketolase activity [ Time Frame: three months ]blood sample
- Iron receptor status [ Time Frame: three months ]blood sample
Biospecimen Retention: Samples Without DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03554668
|Glasgow Royal Infirmary||Recruiting|
|Glasgow, United Kingdom, G4 0SF|
|Contact: Donogh Maguire, MB BCh 0141 2115166 Donogh.Maguire@gla.ac.uk|
|Contact: Blyth Mark, Mb BCh 0141 2114000 Mark.Blyth@ggc.scot.nhs.uk|