Indicators of Growth, Nutritional Status and Comorbide Disorders of Newborns With Down Syndrome (DownSy)
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|ClinicalTrials.gov Identifier: NCT03553706|
Recruitment Status : Completed
First Posted : June 12, 2018
Last Update Posted : June 12, 2018
Objective To access predictive values of the auxological parameters and indexes for risk of comorbid malformations in newborns with Down syndrome (DS)
Study design In this cohort retrospective study, 141 newborns with proven trisomy 21 born at the Department of Gynecology and Obstetrics of the University of Split Hospital (1990 to 2015) were included. The data were obtained from the medical histories of mothers, infants and the delivery protocol.
The objective was to access predictive values of the auxological parameters and indexes for risk of comorbid malformations in newborns with Down syndrome (DS)
Conclusion Higher CI were found in hyportrophic (SGA) newborns with DS and indicated their intrauterine growth restriction with brain sparing and increased further risk of severe psychomotor retardation. The SGA newborns have lower parameters and indexes of nutritive status and significantly differed from eutrophic and hypertrophic newborns. These SGA newborns with DS have increased developmental risks and that requires further diagnostic attention.
|Condition or disease|
|Down Syndrome,Auxological Indexes, Auxological Parametars, Intrauterine Growth Restriction|
Use of anthropometric charts developed specifically for children with DS have a better expression of real growth restriction (small for gestation age/SGA, 9.9%) than the application of the percentile curve for typical children (SGA, 24.1%). These differences were also noted in the evaluation of other anthropometric measures. Cephalization index (CI) proved to be the only predictor from the considered auxological parameters and indexes with minimal predictive value in the prediction of heart defects type ASD II and VSD.
The presence of comorbid disorders in newborns with DS did not have a significant predictive role on growth indicators and nutritive status of the newborn, but we noted a strong association between preterm births and white matter injury (WMI).
|Study Type :||Observational|
|Actual Enrollment :||141 participants|
|Official Title:||Interference Indicators of Growth, Nutritional Status and Comorbid Malformations of Newborns With Down Syndrome (DS)|
|Actual Study Start Date :||May 20, 2018|
|Actual Primary Completion Date :||May 30, 2018|
|Actual Study Completion Date :||May 30, 2018|
- Categorization of subjects according to norms of growth rates for typical children and children with Down syndrome [ Time Frame: 7 days ]Comparison of children with Down syndrome according to values of birth weight, birth length and head circumference classified by anthropometric charts for typical children and anthropometric charts for children with DS
- Testing the differences of auxological characteristic according to gestational age [ Time Frame: 7 days ]Comparison of auxological parameters and auxological indexes of premature and term babies with DS
- Auxological characteristics of SGA, AGA and LGA children with DS by norms for DS [ Time Frame: 7 days ]Comparison of auxological parameters and auxological indexes between hypotrophic (SGA), eutrophic (AGA) and hypertrophic (HGA) children with DS
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Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03553706
|Asija Rota Ceprnja|
|Split, Dalmatia, Croatia, +385 21|
|Principal Investigator:||Asija Rota Ceprnja, MD||University Hospital Split Department for Rehabilitation|