The Impact of Acute Trans-resveratrol Administration on Whole Body Metabolism During Cognitive Demand.
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|ClinicalTrials.gov Identifier: NCT03546075|
Recruitment Status : Completed
First Posted : June 5, 2018
Last Update Posted : June 5, 2018
Background: Increased cerebral vaso-dilation during cognitive demand is hypothesised to improve cognitive performance due to an improved micronutrient status. Despite previous research demonstrating that oral resveratrol can modulate cerebral haemodynamics, this has not translated into expected improvements to cognitive performance in young, healthy populations. As the brain is the most metabolic organ in the body, even subtle changes to fuel utilization and overall energy expenditure are detectable during cognitive demand. The measurement of both overall energy expenditure and fuel utilization may provide further insight to the effects of resveratrol and whether oral supplementation of this polyphenol can provide clear, cognitive benefits in a young, healthy sample.
Objectives: The current study investigated the metabolic consequences of resveratrol on whole body metabolism and fuel oxidisation during cognitive performance.
Methods: This repeated measures, double blind, placebo controlled, balanced design required participants (N=24 for metabolic activity & N=26 for cognitive outcomes) to complete a serial subtraction demand battery at baseline, 45 minutes, 2 and 3 hours following 500 mg, 250 mg trans-resveratrol or inert placebo, on three separate occasions whilst connected to an on-line gas analysis system.
|Condition or disease||Intervention/treatment||Phase|
|Cognitive Change||Dietary Supplement: Resveratrol Other: Placebo||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||27 participants|
|Intervention Model:||Crossover Assignment|
|Masking:||Double (Participant, Investigator)|
|Primary Purpose:||Basic Science|
|Official Title:||The Impact of Acute Trans-resveratrol Administration on Whole Body Metabolism During Cognitive Task Performance: a Double Blind, Randomised, Placebo-controlled Investigation.|
|Actual Study Start Date :||May 7, 2015|
|Actual Primary Completion Date :||December 18, 2015|
|Actual Study Completion Date :||December 18, 2015|
|Experimental: 500 mg Resveratrol||
Dietary Supplement: Resveratrol
|Experimental: 250 mg Resveratrol||
Dietary Supplement: Resveratrol
|Placebo Comparator: Placebo||
- Cognitive performance [ Time Frame: 1 Hour ]Participants completed three Serial subtraction tasks (Serial 3, 7 & 17). Outcomes measured from all three of these tasks were the number correct entries and number of errors. The addition of the two outcomes can also provide a 'total' number of responses entered.
- Whole body metabolism [ Time Frame: 1 Hour ]Whole body energy expenditure was measured via indirect calorimetry and was reported in calories burned per minute (Kcal / min).
- Fuel Oxidisation [ Time Frame: 1 Hour ]Fuel oxidation was measured via indirect calorimetry and examined the rate of carbohydrate and fat oxidisation (both in grams per minute (g / min)).
- Pulmonary gases [ Time Frame: 1 Hour ]An on-line gas analysis system was used to measure oxygen intake and carbon dioxide excretion (both in litres per minute (L / min)) from the participant's expired pulmonary air.