Association Between Proton Pump Inhibitors and Hematologic Toxicity of Pemetrexed (IPPEM)

• ClinicalTrials.gov Identifier: NCT03537833
• Recruitment Status: Recruiting
• First Posted: May 25, 2018
• Last Update Posted: December 16, 2019
• Sponsor: CHU de Reims
• Information provided by (Responsible Party): CHU de Reims

Study Description

Brief Summary:

Pemetrexed is a multi-folate inhibitor approved in the treatment of non-small cell lung cancer (NSCLC) and pleural mesothelioma. Its toxicity profile is mainly hematologic (anemia, neutropenia and thrombopenia) and can be limiting when > grade 2 according to NCI-CTCAE criteria. First clinical trials highlighted hematologic toxicity, especially anemia, which was reduced by decreasing pemetrexed dosage from 600 to 500 mg/m² Q3W and by adding systematic vitamin supplementation (B9/B12). Despite this, incidence of hematological toxicity remains frequent with anemia occurring in more than 20% of patients treated by pemetrexed in combination. Methotrexate, a well-known antineoplastic drugs used in several cancer and non-cancer disease conditions can also induced severe hematologic toxicity in case of methotrexate-reduced elimination and, as a consequence, its accumulation. For example, the elimination of methotrexate is mediated by tubular secretion through type 1 and type 3 organic anion transport (hOAT1 and hOAT3). Association with drugs that inhibits hOATs can induced a hematological toxicity caused by methotrexate accumulation. Among these, proton pump inhibitors (PPIs) are known to inhibit hOATs. The drug interaction that results from their combination with methotrexate is clinically relevant and lead to an increased hematological toxicity. However, hypothetical drug interaction between PPIs and pemetrexed is unknown while pemetrexed seems to be mostly eliminated by hOAT3 (11-fold higher than methotrexate). One study revealed lansoprazole to inhibits in vitro hOAT3. This same study investigates in a retrospective chart patients treated by pemetrexed and the study found a significant association between combination with PPI and hematological toxicity by pemetrexed. Unfortunately this study lacks of relevant methodology and suffered from its retrospective chart. This potential drug interaction must be a real concern for oncologists and clinical pharmacists. The investigators aim to investigate the potential association between PPIs and pemetrexed combination and the incidence of hematological toxicity in a multicenter and prospective study.

Condition or disease	Intervention/treatment
Patients With Non-small Cell Lung Cancer (NSCLC) and Pleural Mesothelioma and Treated With a Pemetrexed-based Chemotherapy	Other: pemetrexed-related hematological toxicity

Detailed Description:

Prospective, longitudinal, multicenter and observational study. All eligible patients will receive clear information about aims and research modalities on the medical consultation and before first course of chemotherapy. If patient agrees with study aims and protocol, disease and therapeutic management will not be change.

Research agree and participation leads to

Data collection:

• Clinical data: weight, height, body mass index

  1. Demographic data: sociodemographic data, comorbidities
  2. Disease data: related to tumor disease and antineoplastic protocol including adjuvant medications like antiemetic of antidiarrheal agents for example.
• complete medication review: a minimum of 3 information sources among the patient and/or family and close, patient health records, community pharmacy, general practitioner,
• activation of a specific study patient record
• biologic data collection: blood count and thrombocythemia during all period study and three week after patient study completion,
• supplementary data in case of hematologic toxicity: hospitalization, growth factors (like erythropoietin and/or granulocyte colony-stimulating factor use), blood transfusions, intravenous iron, chemotherapy treatment delay All patients are followed since inclusion and for 18 months. Research logistic Patients will be recruited in cancer hospital service where patients received pemetrexed in the four study participant centers. Full information and all necessary clarification about study will be explained to all eligible patients with an appropriate consent form. Data collection using case report form will be performed by pharmacists and physicians from hospitalization setting.

Recruiting duration period Twelve months

Subject duration period Eighteen months Subject accessibility Patients will be recruited in one of the four participant centers Statistical analysis Number of patients to include with statistical considerations

It is planned to include 100 patients per group after calculating the number of subjects required (nQuery software) taking into account the following assumptions:

• Risk alpha = 0.05
• Statistical power = 90%
• Percentage of patients without hematologic toxicity in PPI-negative group = 0.62
• Percentage of patients without hematologic toxicity in PPI-positive group = 0.88 (Hazard ratio = 3.74) Statistical analysis methods of criteria Data description will be performed using mean and standard deviation or median (interquartile interval and minimum and maximum) for quantitative variables according to variable distribution and number and percentage for qualitative variables.

Bivariate analysis will be conducted in order to found the association between hematological toxicity or not and clinical variables. Multivariate analysis will be performed with Cox model, using a dependent variable "presence or not of a hematologic toxicity" and independents variables, variables that are associated with a "p" less than 0.20 with confusion factors adjustment.

Treatment of missing data The study will be performed in order to minimize the number of missing data. For each variable number and percentage of missing data will be described.

Study Design

• Study Type: Observational
• Estimated Enrollment: 200 participants
• Observational Model: Cohort
• Time Perspective: Prospective
• Official Title: Association Between Proton Pump Inhibitors and the Incidence of Hematologic Toxicity of Pemetrexed: a Prospective, Multicenter, Observational and Longitudinal Study Among Patients Treated by a Pemetrexed-based Chemotherapy
• Actual Study Start Date: May 2, 2018
• Estimated Primary Completion Date: November 2, 2020
• Estimated Study Completion Date: May 2, 2022

Groups and Cohorts

Group/Cohort	Intervention/treatment
"PPI-positive" or "test group"; Patients treated with PPI	Other: pemetrexed-related hematological toxicity; hematological toxicity will be found on biologic data the day or the day before chemotherapy. Classification will based on NCI-CTCAE criteria
"PPI-negative" or "control group"; Patients not treated with PPI	Other: pemetrexed-related hematological toxicity; hematological toxicity will be found on biologic data the day or the day before chemotherapy. Classification will based on NCI-CTCAE criteria

Outcome Measures

Primary Outcome Measures :

1. Association between PPI consumption and pemetrexed-related hematological toxicity (grade ≥ 3) [ Time Frame: Day 0 ]
   The hematological toxicity will be found on biologic data the day or the day before chemotherapy. Classification will based on NCI-CTCAE criteria

Eligibility Criteria

• Ages Eligible for Study: 18 Years and older (Adult, Older Adult)
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: No
• Sampling Method: Non-Probability Sample

Study Population

Patients who receive a pemetrexed-based chemotherapy regimen for the treatment of non-small cell lung cancer (NSCLC) or mesothelioma

Criteria

Inclusion criteria :

• Patients who receive a pemetrexed-based chemotherapy regimen for the treatment of non-small cell lung cancer (NSCLC) or mesothelioma,
• Patients who consent to participate,
• Patients for whom it is possible to characterize the consumption of proton pump inhibitors with name of the PPI and dosage.

Exclusion criteria :

• Patients who receive pemetrexed out of intravenous of for another condition than NSCLC or mesothelioma
• Patients under 18 or who refused the participation in the data collection,
• Patient previously treated by a pemetrexed-based chemotherapy,
• Patients who first receive a pemetrexed-based regimen with an initial dose adjustment (<500 mg/m²)

Contacts and Locations

Contacts

Contact: Florian SLIMANO; 3 10 73 62 96 ext 0033; fslimano@chu-reims.fr

Locations

France

Chu Reims; Recruiting

Reims, France, 51092

Contact: Damien JOLLY 326788472 ext 33 djolly@chu-reims.fr

Sponsors and Collaborators

CHU de Reims

More Information

• Responsible Party: CHU de Reims
• ClinicalTrials.gov Identifier: NCT03537833
• Other Study ID Numbers: PO18047
• First Posted: May 25, 2018
• Last Update Posted: December 16, 2019
• Last Verified: December 2019

Individual Participant Data (IPD) Sharing Statement:

• Plan to Share IPD: Undecided

• Studies a U.S. FDA-regulated Drug Product: No
• Studies a U.S. FDA-regulated Device Product: No

Additional relevant MeSH terms:

Mesothelioma; Neoplasms; Adenoma; Neoplasms, Glandular and Epithelial; Neoplasms by Histologic Type; Neoplasms, Mesothelial; Pemetrexed; Antineoplastic Agents; Enzyme Inhibitors; Molecular Mechanisms of Pharmacological Action; Folic Acid Antagonists; Nucleic Acid Synthesis Inhibitors