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Trial record 1 of 264 for:    Migraine AND Acute Migraine
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Oxygenation and Perfusion in Patients With Acute Migraine Attacks (OPAMA)

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ClinicalTrials.gov Identifier: NCT03536936
Recruitment Status : Completed
First Posted : May 25, 2018
Last Update Posted : May 25, 2018
Sponsor:
Information provided by (Responsible Party):
University Hospital Inselspital, Berne

Brief Summary:
The aim of the study is to retrospectively evaluate brain perfusion and oxygenation in acute migraine attacks. Magnetic resonance perfusion and susceptibility weighted imaging are the technics to measure perfusion and oxygenation respectively.

Condition or disease
Migraine Migraine With Aura Migraine; Status

Detailed Description:

The aim of the study is to demonstrate a possible correlation between areas of hypoperfusion and prominent cortical veins during migraine attacks.

These focal ares of altered vascular supply of the brain will be evaluated for correlation with topograhy of symptoms.


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Study Type : Observational
Actual Enrollment : 1000 participants
Observational Model: Cohort
Time Perspective: Retrospective
Official Title: Oxygenation and Perfusion in Patients With Acute Migraine Attacks
Actual Study Start Date : January 1, 2010
Actual Primary Completion Date : April 30, 2018
Actual Study Completion Date : April 30, 2018

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Migraine




Primary Outcome Measures :
  1. Focal cerebral hypoperfusion and elevated oxygenation in acute migraine attack [ Time Frame: Patients, who are admitted to hospital, undergo magnetic resonance imaging within 5 days of migraine attack; time frame: symptoms to imaging : 5 days; ]
    Focal cerebral hypoperfusion and elevated oxygenation in acute migraine attack, measured with visual scores on imaging, using a consensus between two readers



Information from the National Library of Medicine

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Ages Eligible for Study:   6 Years to 80 Years   (Child, Adult, Older Adult)
Sexes Eligible for Study:   All
Sampling Method:   Non-Probability Sample
Study Population
Patients who present to hospital emergency with acute symptoms of stroke, undergo MR imaging to exclude stroke or other stroke mimics, and at discharge have confirmed diagnosis of acute migraine attack.
Criteria

Inclusion Criteria:

final clinical diagnosis of migraine

Exclusion Criteria:

brain tumors, seizures/epilepsy, confirmed cerebral infarct from cerebral atery occlusion, sinus vein thrombosis;


Publications of Results:

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Responsible Party: University Hospital Inselspital, Berne
ClinicalTrials.gov Identifier: NCT03536936     History of Changes
Other Study ID Numbers: Migraine Brain Perfusion
First Posted: May 25, 2018    Key Record Dates
Last Update Posted: May 25, 2018
Last Verified: May 2018
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No

Additional relevant MeSH terms:
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Migraine Disorders
Migraine with Aura
Headache Disorders, Primary
Headache Disorders
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases