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Trial record 82 of 245 for:    "ottawa heart institute"

Treatment in Thoracic Aortic Aneurysm: Surgery vs Surveillance (TITAN:SvS)

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ClinicalTrials.gov Identifier: NCT03536312
Recruitment Status : Recruiting
First Posted : May 24, 2018
Last Update Posted : October 25, 2018
Sponsor:
Collaborator:
University of Calgary
Information provided by (Responsible Party):
Ottawa Heart Institute Research Corporation

Brief Summary:

The ascending aorta conducts blood from the heart to the rest of the body. The ascending aorta can become enlarged, and the risk of tearing and rupturing becomes higher with larger aorta. When the ascending aorta tears or ruptures, the risk dying is high even if surgery is done as soon as possible. Traditionally, when the ascending aorta gets above 5.5 cm, surgery is recommended to replace the aorta. However, this threshold is based relatively weak evidence, and sometimes patients with smaller aorta can tear or rupture. On the other hand, surgery carries its own risk as well. Since there are risk of waiting or doing surgery, there is currently no great support for either approach for patients with a smaller aorta. In the TITAN SvS trial, patients with an ascending aorta between 5.0 to 5.5 cm is assigned by chance to the early surgery group, in which they will undergo replacement of aorta, or the surveillance group, in which they will be closely monitored. The chance of dying or suffer tearing or rupture of aorta between the two groups will be compared. The result of the trial will guide future practice for patients with enlarged ascending aorta.

This is a prospective, multi-centre randomized control trial that compares the all-cause mortality, aneurysm-related aortic events, rate of stroke, and quality of life for those patients undergoing early elective ascending aortic surgery to those patients undergoing surveillance. Patients referred for an ascending aortic aneurysm that meets the inclusion criteria will be randomized to the early elective surgery group or the surveillance group. Recruitment will end when the desired sample size is reached, and the patients will be followed for a minimum 2-year period. The primary objective of the trial is to compare the composite outcome of the all-cause mortality and incidence of acute aortic events between surveillance and elective ascending aortic surgery for patients with degenerative or bicuspid valve-related ascending aortic aneurysm after 2 years of follow up. The hypothesis is that the early surgery group will have a significantly lower all-cause mortality and incidence of acute aortic events at 2 years of follow up compare to the surveillance group. The result of this trial will provide evidence based guidance in the appropriate management of ascending aortic aneurysm based on the size criteria, and establish a large database for future investigations.


Condition or disease Intervention/treatment Phase
Ascending Aortic Aneurysm Enlargement Ascending Aorta Aneurysm Procedure: Thoracic Aortic Surgery Not Applicable

Detailed Description:

All patients referred electively to a participating investigator for the evaluation of their ascending aortic aneurysm will be screened for study eligibility. Patients between the age of 18 and 79 with an asymptomatic ascending aortic aneurysm between 5.0 cm and 5.4 cm in maximal diameter are entered into the randomization study. Patients with ascending aortic aneurysm with a diameter of 4.5 cm - 4.9 cm will be observed with serial CT, and will be considered for enrollment into the trial once the aneurysm reaches 5.0 cm.

When the patient is first assessed in clinic, a pre-randomization evaluation will be completed. Baseline information of the patient, including demographics, past medical history, family history, medications, smoking habits, and the characteristics of the aneurysm, is collected. Measurements including weight, height, heart rate, blood pressure in both arms, is recorded. Basic blood work, including hemoglobin, white cell count, platelets, electrolytes, creatinine, random blood sugar, HbA1c, and cholesterol profile is taken for analysis. An electrocardiograph, chest X-ray, and a CT scan from the surgeon's institution is also obtained. SF-36, the quality of life questionnaire, will be completed by the patient. Those patients that are suitable for the trial based on inclusion and exclusion criteria will then be randomized en-site through a computer-generated randomization program.

For the patients randomized to elective surgery group, the surgery is scheduled within 10-12 weeks of randomization. In the interim, the patient will be placed on maximal medical therapy for their aneurysm, including beta-blocker, statin, and blood pressure control, and the doses of these medication will be individualized based on each patient's own physiological response. The types of surgery (ascending aortic replacement, Bentall procedure, valve-sparing root replacement, etc.) will be at the discretion of the surgeon. The details of the surgery and the patient's course of postoperative hospital stay is recorded. The patient will be managed postoperatively according to routine hospital care. After discharge, patients will be seen at 1 months for their routine postoperative follow up, then annually counting from their index clinic visit before the surgery. At the first postoperative clinic visit, weight, height, heart rate, blood pressure in both arms, is recorded. Basic blood work, including hemoglobin, white cell count, platelets, electrolytes, creatinine is taken for analysis. An electrocardiograph and chest X-ray will be obtained. All subsequent clinic visits can be done in person or by phone conducted by a study coordinator. A CT scan will be obtained at all subsequent clinic visits. Mortality status and occurrence of acute aortic event or stroke in the previous year will be assessed at every annual clinic visit. Quality of life assessment by SF-36 questionnaire will be completed by the patient in person or by phone at 1 year and 2 years follow-up. Annual follow-up will continue until either the patient dies or the trial ends. Patients who are randomized to the surveillance group will be placed on maximal medical therapy for their aneurysm, including beta-blocker, statin, and blood pressure control. The doses of these medication will be individualized based on each patient's own physiological response. The patients will undergo a CT scan of the chest at the first clinic visit then annually for the duration of the study. All CTs will be uploaded to a core CT imaging lab where the image will be reviewed by a Radiologist. If the aneurysm grows beyond 5.5 cm or the patient develop symptoms, the surgeon will consider the patient for surgery. At all clinic visits, in addition to CT, weight, height, heart rate, blood pressure in both arms, an electrocardiograph, and a chest X-ray will be obtained. The surveillance visits continue until either the patient dies, the trial ends, or surgery is considered. If the patient is no longer considered a suitable candidate for surgery or refuse surgery, follow-up will continue, and the patient will no longer be a part of the trial and will only be registered in the side arm.


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Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 446 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Intervention Model Description: Patients between the age of 18 and 79 with an asymptomatic ascending aortic aneurysm between 5.0 cm and 5.4 cm in maximal diameter are entered into the randomization study. Patients with ascending aortic aneurysm with a diameter of 4.5 cm - 4.9 cm will be observed with serial CT, and will be considered for enrolment into the trial once the aneurysm reaches 5.0 cm.
Masking: Single (Outcomes Assessor)
Masking Description: Information will be encrypted for assessors
Primary Purpose: Other
Official Title: Treatment in Thoracic Aortic Aneurysm: Surgery vs Surveillance (TITAN:SvS)
Actual Study Start Date : September 1, 2018
Estimated Primary Completion Date : May 31, 2025
Estimated Study Completion Date : May 31, 2026

Resource links provided by the National Library of Medicine


Arm Intervention/treatment
No Intervention: Surveillance Arm
Patients in the Non-Operative Registry will be followed in clinic annually with a CT scan to monitor the status of their ascending aortic aneurysm, until the end of the study, the occurrence of an aortic event, or death.
Surgery/Treatment Arm
Patients in the Operative Registry will have thoracic aortic surgery
Procedure: Thoracic Aortic Surgery
Thoracic aortic surgery to treat thoracic aortic aneurysm




Primary Outcome Measures :
  1. All-cause mortality and incidence of acute aortic events in both surveillance and elective ascending aortic surgery groups for patients with degenerative or bicuspid valve-related ascending aortic aneurysm after 2 years of follow up. [ Time Frame: 2 years ]
    At 2 years follow up, number of patients in surveillance versus treatment group suffering from mortality or acute aortic dissection


Secondary Outcome Measures :
  1. Intraoperative mortality and 30 day mortality of ascending aortic aneurysm repair [ Time Frame: 30 days from surgery ]
    Document death during surgery or within 30 days post surgery

  2. Incidence of need for elective ascending aortic aneurysm repair in the surveillance group [ Time Frame: 2 years ]
    How many patients on the surveillance arm of the trial need to have surgery prior to the end of trial surveillance

  3. Non aneurysm related death [ Time Frame: 2 years ]
    How many patients in either surgical or surveillance arm have a non aneurysm related death

  4. Aneurysm related death [ Time Frame: 2 years ]
    How many patients in either the surveillance or surgical arm have an aneurysm related death

  5. Incidence of cerebrovascular accidents (CVA) [ Time Frame: 2 years ]
    How many patients have a CVA on the surgical or surveillance arm

  6. Annual growth rate in diameter of ascending aortic aneurysm in the surveillance group [ Time Frame: 2 years ]
    Prospective assessment of the rate of growth in mm/yr of moderate sized ascending aortic aneurysms

  7. Quality of life at 1 year and 2 years for both groups [ Time Frame: 2 years ]
    Patients will fill in questionnaires to assess impact of surveillance strategy versus surgery on quality of life



Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


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Ages Eligible for Study:   18 Years to 79 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  1. All patients referred electively to a participating investigator for the evaluation of their ascending aortic aneurysm will be screened for study eligibility.
  2. Patients between the age of 18 and 79 with an asymptomatic ascending aortic aneurysm between 5.0 cm and 5.4 cm in maximal diameter are entered into the randomization study.
  3. Patients with ascending aortic aneurysm with a diameter of 4.5 cm - 4.9 cm will be observed with serial CT, and will be considered for enrollment into the trial once the aneurysm reaches 5.0 cm.

Exclusion Criteria:

  1. Patients with symptomatic attributable to ascending aortic aneurysms
  2. Patients who are unable to give informed consents
  3. Patients who are unable to attend for regular follow-up/compliant with protocol
  4. Previous cardiac surgery
  5. Patients whose primary indication for cardiac surgery is non-AsAA related
  6. AsAA expansion rate exceeding 0.5 cm/year
  7. Arch aneurysms with no ascending aorta involvement (no aneurysmal segments before the innominate artery)
  8. Ascending aortic and arch aneurysm with descending thoracic aorta involvement
  9. Patients with known connective tissue disease (E.g. Marfan syndrome, Loey-Dietz, Turner syndrome, etc.)
  10. Patients with possible genetic aortopathies (family history of aortic aneurysms/premature aortic dissections/ruptures)
  11. Patients with inflammatory arteritis (takayasu's arteritis, syphilitic arteritis, etc.)
  12. Those who are deemed unfit for surgery (will not be included in the randomized control trial but will be included in the registry)

    • Severe pulmonary disease
    • Cr = 250
    • Child Pugh Class B or C
    • NYHA III or IV
    • MI within the last 6 months
    • Major surgical procedure or angioplasty within 3 months
    • Expected survival less than 5 years because of other disease (e.g. invasive cancer)

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03536312


Contacts
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Contact: Jehangir Appoo, MD 4039442515 jehangir.appoo@ahs.ca
Contact: Clare Russell 4039442515 clare.russell@ahs.ca

Locations
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Canada, Alberta
University of Calgary Recruiting
Calgary, Alberta, Canada, T2N 2T9
Contact: Clare Russell    4039442515    clare.russell@ahs.ca   
Contact: Jehangir Appoo, MD    4039442515    jehangir.appoo@ahs.ca   
Principal Investigator: Jehangir Appoo, MD         
Sub-Investigator: Alexander Gregory, MD         
Sub-Investigator: Vamshi Kotha, MD         
Sub-Investigator: Herget Eric, MD         
Canada, Ontario
University of Ottawa Heart Institute Recruiting
Ottawa, Ontario, Canada, K1Y 4W7
Contact: Munir Boodhwani, MD    6136967237    MBoodhwani@ottawaheart.ca   
Principal Investigator: Munir Boodhwani, MD         
Sponsors and Collaborators
Ottawa Heart Institute Research Corporation
University of Calgary
Investigators
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Principal Investigator: Munir Boodhwani, MD Ottawa Heart Institute Research Corporation

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Responsible Party: Ottawa Heart Institute Research Corporation
ClinicalTrials.gov Identifier: NCT03536312     History of Changes
Other Study ID Numbers: REB17-2124
First Posted: May 24, 2018    Key Record Dates
Last Update Posted: October 25, 2018
Last Verified: October 2018
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No

Additional relevant MeSH terms:
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Aneurysm
Aortic Aneurysm
Hypertrophy
Aortic Aneurysm, Thoracic
Vascular Diseases
Cardiovascular Diseases
Aortic Diseases
Pathological Conditions, Anatomical