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Behavioral Economic Analysis of Demand for Marijuana

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ClinicalTrials.gov Identifier: NCT03518567
Recruitment Status : Recruiting
First Posted : May 8, 2018
Last Update Posted : October 23, 2018
Sponsor:
Information provided by (Responsible Party):
Elizabeth Aston, Brown University

Brief Summary:
This laboratory study will employ a multi-session experimental design to examine the behavioral economic demand for marijuana, by studying effect of marijuana administration (High THC) on demand for marijuana, and marijuana smoking topography. The study will recruit 100 non-treatment seeking marijuana users who smoke marijuana at least twice weekly.

Condition or disease Intervention/treatment Phase
Marijuana Smoking Drug: Smoked marijuana cigarettes: High THC dose (6% THC) Phase 2

Detailed Description:
This laboratory study will employ a multi-session experimental design to examine craving for marijuana, the effect of marijuana administration (High THC) on behavioral economic demand for marijuana, and marijuana smoking topography. The study will recruit 100 non-treatment seeking marijuana users who smoke marijuana at least twice weekly. The relationship between hypothetical and actual demand for marijuana will be examined. We will also investigate relationship between demand for marijuana and indices of marijuana smoking topography. The study will recruit 100 non-treatment seeking marijuana users who smoke marijuana at least twice weekly to obtain a final sample of 85 with complete data (15% of attrition). Participants will be tested at a baseline session and during two experimental sessions (an ad libitum marijuana smoking session and a marijuana smoking topography session). This study will confirm the utility of the hypothetical marijuana purchase task as a reliable and valid tool for assessing behavioral economic marijuana demand.

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Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 100 participants
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Official Title: Behavioral Economic Analysis of Demand for Marijuana
Actual Study Start Date : October 15, 2018
Estimated Primary Completion Date : April 30, 2020
Estimated Study Completion Date : April 30, 2020

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Marijuana

Arm Intervention/treatment
Experimental: High THC dose (6% THC)
Smoked marijuana cigarettes (High THC dose [6% THC])
Drug: Smoked marijuana cigarettes: High THC dose (6% THC)
Smoked marijuana cigarettes (High THC dose [6% THC])




Primary Outcome Measures :
  1. Change in Marijuana Purchase Task (MPT) [ Time Frame: MPT will be administered twice during the experimental session, up to 6 hours: at baseline and pre-smoking ]
    The Marijuana Purchase Task will be used to collect data on marijuana demand. Participants indicate how much marijuana they would purchase at varying levels of price (e.g., free - $60). Indices of marijuana demand are derived from the task and used to determine the relative value of marijuana for each participant.


Secondary Outcome Measures :
  1. Change in Marijuana Craving Questionnaire (MCQ) [ Time Frame: The MCQ will be administered pre- and post- marijuana smoking during the experimental session, up to 6 hours ]
    The Marijuana Craving Questionnaire will be used to collect data on craving for marijuana.

  2. Marijuana Smoking Topography [ Time Frame: Marijuana smoking topography indices will be collected during the ad libitum marijuana smoking topography experimental session, up to 6 hours ]
    Indices of Marijuana Smoking Topography will be obtained during the experimental session. Participants will smoke marijuana through a smoking topography device. The device tracks number of puffs, puff length, and inter-puff-interval.



Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 50 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • marijuana use at least 8 times in the past month on average and at least monthly for the past 6 months
  • English-speaking
  • negative urine toxicology screen for drugs other than marijuana
  • non-treatment seeking
  • purchase of marijuana at least twice in the past 6 months to confirm familiarity with the construct to be measured

Exclusion Criteria:

  • positive pregnancy test
  • nursing
  • inability to use contraception during the study
  • poor physical health
  • positive breath alcohol concentration
  • diagnosis of a current affective disorder, psychosis, and panic disorder
  • self-report of past serious adverse reaction to marijuana
  • current psychotropic drug use
  • smoking more than 20 tobacco cigarettes per day
  • inability to abstain from marijuana for 15 hours
  • body mass index outside 18.5-30 kg/m2 range

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03518567


Contacts
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Contact: Elizabeth Aston, PhD 401-863-6668 elizabeth_aston@brown.edu

Locations
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United States, Rhode Island
Brown University Recruiting
Providence, Rhode Island, United States, 02903
Contact: Elizabeth Aston, PhD    401-863-6668      
Contact: Jane Metrik, PhD    401-863-6650      
Sponsors and Collaborators
Brown University
Investigators
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Principal Investigator: Elizabeth Aston, PhD Brown University

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Responsible Party: Elizabeth Aston, Assistant Professor, Brown University
ClinicalTrials.gov Identifier: NCT03518567     History of Changes
Other Study ID Numbers: #1502001185
First Posted: May 8, 2018    Key Record Dates
Last Update Posted: October 23, 2018
Last Verified: October 2018

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Studies a U.S. FDA-regulated Drug Product: Yes
Studies a U.S. FDA-regulated Device Product: No

Additional relevant MeSH terms:
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Marijuana Abuse
Marijuana Use
Substance-Related Disorders
Chemically-Induced Disorders
Mental Disorders