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Strain for Risk Assessment and Therapeutic Strategies in Patients With Acute Heart Failure (STRATS-AHF) Registry (STRATS-AHF)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT03513653
Recruitment Status : Active, not recruiting
First Posted : May 1, 2018
Last Update Posted : October 22, 2020
Sponsor:
Collaborators:
Seoul National University Bundang Hospital
Chungnam National University Hospital
Information provided by (Responsible Party):
Goo-Yeong Cho, Seoul National University Bundang Hospital

Study Description
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Brief Summary:
STRATS-AHF (STrain for Risk Assessment and Therapeutic Strategies in patients with Acute Heart Failure) registry enrolled 4,312 patients hospitalized for acute HF from 3 tertiary university hospitals (Seoul National University Bundang Hospital, Seoul National University Hospital, and Chungnam National University Hospital) from January 2009 through December 2016.

Condition or disease Intervention/treatment
Heart Failure Acute Heart Failure Echocardiography Diagnostic Test: Echocardiography with speckle-tracking imaging

Detailed Description:
Patients with signs or symptoms of heart failure and either lung congestion, or objective findings of left ventricular (LV) systolic dysfunction or structural heart disease, were eligible for the study. Echocardiography was performed and both LV ejection fraction (LVEF) and LV global longitudinal strain (LV-GLS), right ventricular GLS (RV-GLS) were measured.
Study Design
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Study Type : Observational
Actual Enrollment : 4312 participants
Observational Model: Cohort
Time Perspective: Retrospective
Official Title: Strain for Risk Assessment and Therapeutic Strategies in Patients With Acute Heart Failure (STRATS-AHF) Registry
Actual Study Start Date : January 1, 2009
Actual Primary Completion Date : September 5, 2017
Estimated Study Completion Date : December 31, 2022

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Heart Failure

Groups and Cohorts
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Group/Cohort Intervention/treatment
Acute heart failure
Patients hospitalized for acute heart failure and underwent echocardiography with speckle-tracking imaging
 Diagnostic Test: Echocardiography with speckle-tracking imaging
  1. Measurement of left ventricular ejection fraction and global longitudinal strain
  2. Measurement of left atrial reservoir strain (peak atrial longitudinal strain)
  3. Measurement of right ventricular global longitudinal strain


Outcome Measures
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Primary Outcome Measures :
  1. All-cause mortality [ Time Frame: up to 5 years ]
    Death from any cause


Secondary Outcome Measures :
  1. Hospitalization for heart failure [ Time Frame: up to 5 years ]
    Any hospitalization for acute heart failure after the index hospitalization

  2. Composite of all-cause mortality and hospitalization for heart failure [ Time Frame: up to 5 years ]
    Death from any cause or any hospitalization for acute heart failure after the index hospitalization

  3. Ischemic stroke [ Time Frame: up to 5 years ]
    Ischemic stroke (an episode of neurological dysfunction caused by embolism) after the index hospitalization


Eligibility Criteria
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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Patients hospitalized for acute heart failure
Criteria

Inclusion Criteria:

  • Patients with signs or symptoms of HF and either lung congestion, or objective findings of LV systolic dysfunction or structural heart disease

Exclusion Criteria:

  • Patients who presented with acute coronary syndrome
Contacts and Locations
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Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03513653


Locations
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Korea, Republic of
Seoul National University Bundang Hospital
Seongnam-si, Gyeonggi-do, Korea, Republic of, 13620
Chungnam National University Hospital
Daejeon, Korea, Republic of, 35015
Seoul National University Hospital
Seoul, Korea, Republic of, 03080
Sponsors and Collaborators
Seoul National University Hospital
Seoul National University Bundang Hospital
Chungnam National University Hospital
Investigators
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Principal Investigator: Goo-Yeong Cho, MD, PhD Seoul National University Bundang Hospital
More Information
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Publications:

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):

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Responsible Party: Goo-Yeong Cho, Professor, Seoul National University Bundang Hospital
ClinicalTrials.gov Identifier: NCT03513653    
Other Study ID Numbers: B-1702/384-111
First Posted: May 1, 2018    Key Record Dates
Last Update Posted: October 22, 2020
Last Verified: October 2020
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: Undecided

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Keywords provided by Goo-Yeong Cho, Seoul National University Bundang Hospital:
acute heart failure
global longitudinal strain
ejection fraction
echocardiography
mortality
Additional relevant MeSH terms:
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Heart Failure
Heart Diseases
Cardiovascular Diseases