Value on Survival of Liver Volume After an Acute Decompensation of an Alcoholic Cirrhosis (PROLIV)
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Investigator seek to determine whether the volume of the liver can predict the survival after a decompensation of a patient suffering from chronic liver disease caused by excessive alcohol consumption (or alcoholic cirrhosis). Our hypothesis is that patients with a "small" liver have a lower survival compared to patients having a "normal" sized liver.
Condition or disease
Alcoholic CirrhosisAlcoholic Liver Disease
In this observational, prospective and multicentre clinical trial, investigator seek to determine the prognostic value of liver volume during an acute decompensation. Investigator plan to enroll admitted adult patients with acute decompensation of an alcoholic cirrhosis (abstinent or not), followed for one year or until death or liver transplantation. Liver volume will be evaluated using CT-scan or MRI reconstructions.
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Layout table for eligibility information
Ages Eligible for Study:
18 Years and older (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
All patients suffering from alcoholic cirrhosis, withdrawn or not, hospitalised for an acute decompensation
Patient suffering from alcoholic cirrhosis (withdrawn or not)
Patient admitted in emergency for an alcoholic cirrhosis decompensation only
Prescription for a cutting imaging (CT scan or MRI) during hospitalisation
Alcohol consumption of more than 3 units per day for men and 2 units for women in average, over at least the last 5 years before the cirrhosis diagnosis
Patient suffering from decompensated cirrhosis defined by at least one of the following criteria : Model For End-Stage Liver Disease (MELD) score above or equal to 15, ascites needing iterative punctures, symptomatic bacterial ou fungal infections, acute digestive bleeding due to portal hypertension, hepatic encephalopathy defined by a West Haven score above or equal to 2
Nodule with typical criteria of hepatocellular carcinoma
B or C viral infections actives
Presence of transjugular intrahepatic portosystemic shunt (TIPS)
Presence of an occlusive thrombosis of the porta or one of the principal branches