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Efficacy of Wet Cupping on Reactive Oxygen Species and Antioxidants

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ClinicalTrials.gov Identifier: NCT03503903
Recruitment Status : Completed
First Posted : April 20, 2018
Last Update Posted : February 26, 2019
Sponsor:
Information provided by (Responsible Party):
SULEYMAN ERSOY, Karabuk University

Brief Summary:
This study evaluates the efficacy of Wet cupping Therapy on oxidative stress and antioxidant capacity of the body.The healthy volunteers will receive wet cupping application and their initial venous blood samples and samples after the treatment will be evaluated for oxidative stress.

Condition or disease Intervention/treatment Phase
Healthy Procedure: Wet Cupping Not Applicable

Detailed Description:
Among the healthy individuals who applied for Wet Cupping Therapy (WCT) to Traditional and Complementary Therapies center in Karabuk Medical Faculty Education and Research Hospital for general wellbeing 24 volunteers were enrolled in the study. They will receive three concecutive WCT application in one month interval.Their venous blood samples obtained initially and after the completion of the three concecutive applications, will be evaluted in terms of Reactive Oxygen species and Antioxidant capacity.Additionally samples from the cupping blood during the first and the third WCT application will also be obtained and evaluated.

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 24 participants
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Efficacy of Wet Cupping on Reactive Oxygen Species and Antioxidant Capacity:A Self-controlled Interventional Study
Actual Study Start Date : March 1, 2018
Actual Primary Completion Date : July 15, 2018
Actual Study Completion Date : August 1, 2018

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Antioxidants

Arm Intervention/treatment
Experimental: Wet Cupping
One armed self-controlled study. Individuals in this arm will receive three concecutive WCT application
Procedure: Wet Cupping
CT was applied using plastic disposable vacuum cups on the back in the 5 areas of C7 cervical spine (DU14 acupoint), T2-4 lateral spine bilaterally (BL41-42 acupoint) and T6-8 lateral spine bilaterally (BL44-46), which are the recommended sites for headache (12). The cupping technique procedure was conducted in five phases:Primary suction,Area disinfection,Scarification,Secondary suction and bloodletting,Removing and dressing.




Primary Outcome Measures :
  1. TAS [ Time Frame: 7 days ]
    Total antioxidant status

  2. TOS [ Time Frame: 7 days ]
    Total oxidant status


Secondary Outcome Measures :
  1. SOD [ Time Frame: 7 days ]
    Super oxide dismutase

  2. CAT [ Time Frame: 7 days ]
    Catalase



Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 50 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

Healthy male adults

Must apply Traditional and complemantary medicine center for general well being.

Exclusion Criteria:

Any chronic disorder

Antiagregant drug usage

Bleeding disorders

-


Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03503903


Locations
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Turkey
Karabuk University Karabuk Research and Education hospital
Karabük, Karabuk, Turkey, 78070
Sponsors and Collaborators
Karabuk University
Investigators
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Principal Investigator: SULEYMAN ERSOY Karabuk University
  Study Documents (Full-Text)

Documents provided by SULEYMAN ERSOY, Karabuk University:
Study Protocol  [PDF] January 5, 2018
Statistical Analysis Plan  [PDF] January 5, 2018


Publications:
. Burton, M. Smith, T. Falkenberg, Building WHO's global strategy for traditional medicine, European Journal of Integrative Medicine 7(1) (2015) 13-15.
M. Ahmedi, M.R. Siddiqui, The value of wet cupping as a therapy in modern medicine-An Islamic Perspective, (2014).
S. El Sayed, H. Mahmoud, M. Nabo, Methods of wet cupping therapy (Al-Hijamah): in light of modern medicine and prophetic medicine, Alternative & Integrative Medicine (2013) 1-16.

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Responsible Party: SULEYMAN ERSOY, Asist.Prof. Department of Family Medicine, Karabuk University
ClinicalTrials.gov Identifier: NCT03503903     History of Changes
Other Study ID Numbers: KBU-BAP-17/1-KA-070
First Posted: April 20, 2018    Key Record Dates
Last Update Posted: February 26, 2019
Last Verified: February 2019
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: Undecided

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Keywords provided by SULEYMAN ERSOY, Karabuk University:
Wet cupping therapy
antioxidant capacity
Additional relevant MeSH terms:
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Antioxidants
Molecular Mechanisms of Pharmacological Action
Protective Agents
Physiological Effects of Drugs