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Trial record 36 of 228 for:    EDN1

Short-term Effects of Tai Chi Chuan Exercise on the Regulation of Lipid and Glucose Metabolisms and Endothelial Function

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ClinicalTrials.gov Identifier: NCT03503084
Recruitment Status : Completed
First Posted : April 19, 2018
Last Update Posted : April 19, 2018
Sponsor:
Collaborator:
Taipei Veterans General Hospital, Taiwan
Information provided by (Responsible Party):
Cheng-Deng Kuo, Changhua Christian Hospital

Brief Summary:
The short term effects of TCC exercise are the significant increase in serum insulin and insulin resistance, and the significant decrease in serum TC, HDL-C, ET-1 and insulin sensitivity in TCC practitioners. TCC might be benefit the health of its practitioners through the regulation of lipid and glucose metabolism and endothelial function.

Condition or disease Intervention/treatment Phase
Physiological Effect of TCC on Glucose Metabolism Behavioral: Classical Yang's TCC exercise Not Applicable

Detailed Description:
Tai Chi Chuan (TCC) has been shown to be beneficial to the health. However, its effects on lipid and glucose metabolism are not fully understood. This study investigated the short term effect of TCC exercise on lipid and glucose metabolism and endothelial function in TCC practitioners. Twenty-one TCC practitioners and nineteen normal controls were included in this study. The hemodynamics, serum insulin, indices of insulin resistance/sensitivity, serum endothelin-1 (ET-1), blood lipids and aldosterone before and 30 min after a rest or a session of classical Yang's TCC exercise were compared.

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 40 participants
Intervention Model: Single Group Assignment
Intervention Model Description: Twenty-one TCC practitioners and nineteen normal controls were included in this study. The hemodynamics, serum insulin, indices of insulin resistance/sensitivity, serum endothelin-1 (ET-1), blood lipids and aldosterone before and 30 min after a rest or a session of classical Yang's TCC exercise were compared.
Masking: None (Open Label)
Primary Purpose: Health Services Research
Official Title: The Effect of Tai Chi Chuan on the Endothelin, Insulin, Blood Lipid, Blood Sugar, Aldosterone and Hemodynamics in the Elderly Adults
Actual Study Start Date : May 1, 2009
Actual Primary Completion Date : November 30, 2009
Actual Study Completion Date : December 31, 2009

Resource links provided by the National Library of Medicine


Arm Intervention/treatment
Experimental: TCC group
Classical Yang's TCC exercise
Behavioral: Classical Yang's TCC exercise



Primary Outcome Measures :
  1. change in quantitative insulin sensitivity check index [ Time Frame: before and 30 minutes after the completion of TCC exercise ]
    change in insulin sensitivity due to TCC


Secondary Outcome Measures :
  1. change in serum total cholesterol [ Time Frame: before and 30 minutes after the completion of TCC exercise ]
    change in serum total cholesterol due to TCC

  2. change in homeostasis model assessment-estimated insulin resistance [ Time Frame: before and 30 minutes after the completion of TCC exercise ]
    change in insulin resistance by TCC


Other Outcome Measures:
  1. change in serum triglyceride [ Time Frame: before and 30 minutes after the completion of TCC exercise ]
    change in serum level of triglyceride due to TCC

  2. change in serum low density lipoprotein [ Time Frame: before and 30 minutes after the completion of TCC exercise ]
    change in serum level of low density lipoprotein due to TCC

  3. change in serum high density lipoprotein [ Time Frame: before and 30 minutes after the completion of TCC exercise ]
    change in serum level of high density lipoprotein due to TCC

  4. change in serum insulin [ Time Frame: before and 30 minutes after the completion of TCC exercise ]
    change in serum level of insulin due to TCC

  5. change in serum endothelin-1 [ Time Frame: before and 30 minutes after the completion of TCC exercise ]
    change in serum level of endothelin-1 due to TCC

  6. change in serum aldosterone [ Time Frame: before and 30 minutes after the completion of TCC exercise ]
    change in serum level of aldosterone due to TCC



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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • TCC practitioners in a TCC training center in Taiwan over 50 years of age
  • Healthy subjects without TCC experience over 50 years of age

Exclusion Criteria:

  • Subjects who had major cardiopulmonary disease
  • Subjects who have diabetes mellitus, renal or liver disease

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03503084


Locations
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Taiwan
Wan-An Lu
Ilan, Taiwan
Sponsors and Collaborators
Changhua Christian Hospital
Taipei Veterans General Hospital, Taiwan
Investigators
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Principal Investigator: Cheng-Deng Kuo, MD,PhD Changhua Christian Hospital

Publications of Results:

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Responsible Party: Cheng-Deng Kuo, Principal Investigator, Changhua Christian Hospital
ClinicalTrials.gov Identifier: NCT03503084     History of Changes
Other Study ID Numbers: V98E2-014
First Posted: April 19, 2018    Key Record Dates
Last Update Posted: April 19, 2018
Last Verified: April 2018
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No
Plan Description: Individual participant data (IPD) are available after the manuscript has been accepted for publication

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Keywords provided by Cheng-Deng Kuo, Changhua Christian Hospital:
Tai Chi Chuan
insulin resistance
cholesterol
endothelin-1
Additional relevant MeSH terms:
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Insulin
Hypoglycemic Agents
Physiological Effects of Drugs