Lymphocyte Markers As Predictors Of Responsiveness To Rituximab Among Patients With Idiopathic Nephrotic Syndrome
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Resolution of proteinuria (urine protein:creatinine <0.02 g/mmol or urine protein excretion <0.3 g/1.73m2/day) and ability to wean off prednisolone and calcineurin inhibitor at three months after the last dose of rituximab.
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Layout table for eligibility information
Ages Eligible for Study:
1 Year and older (Child, Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Age 1-18 years old at the time of diagnosis of nephrotic syndrome
Steroid-dependent (SDNS) or steroid-resistant nephrotic syndrome (SDNS)
eGFR <60 ml/min per 1.73m2
infantile onset of nephrotic syndrome
nephrotic syndrome secondary to chronic infections such as hepatitis B, hepatitis C or human immunodeficiency virus, systemic lupus erythematosus, Henoch-Schönlein purpura, IgA nephropathy, membranoproliferative glomerulonephritis or membranous nephropathy
current or previous therapy for tuberculosis
presence of mutations in WT1, NPHS1, NPHS2 and TRPC6.