European Paediatric AFM Associated With EV-D68 Follow-up Study.
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The study is a follow-up study on children with acute flaccid paresis associated with enterovirus D68 infection. Only children living in Europe are eligible. The study aim is to clarify the outcome of the disease and investigate possible clinical correlation with outcome, including initial severity, demographic characteristics, treatment and MRI findings.
Total Hammersmith Functional Motor scale- score at follow-up [ Time Frame: 1 year ]
O'Hagen, J. M., et al. (2007). "An expanded version of the Hammersmith Functional Motor Scale for SMA II and III patients." Neuromuscul Disord 17(9-10): 693-697.Neurol. 2003;7(4):155-9.
The scale is a 33 items evaluation (0, 1 or 2 points in each item) and results in an overall functional score. Range: 0-66, with a higher score reflecting better performance. No sub-scores will be used.
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Layout table for eligibility information
Ages Eligible for Study:
up to 18 Years (Child, Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Acute flaccid paresis (AFP) at onset, and
Enterovirus D-68 polymerase chain reaction (PCR) positive in any specimen in a timely sample (+/- 3 weeks from onset of paresis), and
Age <18 years at onset, and
Magnetic resonance imaging (MRI) of spine and brain at onset with signs of myelitis.
central nervous system (CNS) malignancy
Bleeding or infarctions in CNS
Previous demyelinating disease
Other infections cause of myelitis is more likely
Patient and/or legal guardian is not able/willing to sign the consent form