Effects of Black Pepper on the Absorption of Nutrients in Vegetables
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ClinicalTrials.gov Identifier: NCT03490955 |
Recruitment Status : Unknown
Verified September 2018 by University of Massachusetts, Amherst.
Recruitment status was: Not yet recruiting
First Posted : April 6, 2018
Last Update Posted : November 16, 2018
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Condition or disease | Intervention/treatment | Phase |
---|---|---|
Black Pepper Absorption Carotenoid | Other: salad dressing and black pepper Other: salad dressing Other: black pepper Other: salad | Not Applicable |
Study Type : | Interventional (Clinical Trial) |
Estimated Enrollment : | 16 participants |
Allocation: | Randomized |
Intervention Model: | Crossover Assignment |
Masking: | Single (Investigator) |
Primary Purpose: | Treatment |
Official Title: | Effects of Black Pepper on the Absorption of Nutrients in Vegetables |
Estimated Study Start Date : | December 6, 2018 |
Estimated Primary Completion Date : | June 15, 2019 |
Estimated Study Completion Date : | June 30, 2019 |

Arm | Intervention/treatment |
---|---|
Sham Comparator: Salad
Subjects will consume a vegetable salad without dressing one time in the morning.
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Other: salad
Subjects will consume a vegetable salad without dressing and without black pepper one time in the morning |
Active Comparator: Salad dressing
Subjects will consume a vegetable salad with dressing one time in the morning
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Other: salad dressing
Subjects will consume a vegetable salad with dressing one time in the morning |
Active Comparator: black pepper
Subjects will consume a vegetable salad without dressing but with black pepper one time in the morning
|
Other: black pepper
Subjects will consume a vegetable salad without dressing but with black pepper one time in the morning |
Active Comparator: Salad dressing and black pepper
Subjects will consume a vegetable salad with dressing and with black pepper one time in the morning
|
Other: salad dressing and black pepper
Subjects will consume a vegetable salad with black pepper and dressing one time in the morning |
- Determine the level of carotenoids in blood [ Time Frame: 12-16 weeks ]Utilize HPLC to quantify blood levels of carotenoids in subjects consumed test articles

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Ages Eligible for Study: | 18 Years to 30 Years (Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
- 18-30 year old healthy adults
Exclusion Criteria:
- those who are <18 or >30 years old, have a BMI of <20 or >29 kg/m2, have a weight change >4.5 kg (9.91 pounds) in the past 3 months, exceed exercise activities of a recreational level over the past 3 months, have any diseases, especially intestinal disorders including lipid malabsorption or lactose intolerance, had abnormal liver or kidney function tests.
- Those who smoke, consume more than two alcoholic drinks per day, use medication affecting lipid profiles or dietary supplements affecting plasma cholesterol (e.g., Benocol or fiber supplements) will also be excluded.
- Additionally, this study excludes menopausal women, those using hormone-based contraceptives, those with abnormal menstrual cycles, and those who are pregnant, lactating or planning to become pregnant.

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03490955
Contact: Hang Xiao | 4135452281 | hangxiao@foodsci.umass.edu | |
Contact: Zhengze Li | 4135452281 | zhengzeli@foodsci.umass.edu |
Responsible Party: | University of Massachusetts, Amherst |
ClinicalTrials.gov Identifier: | NCT03490955 |
Other Study ID Numbers: |
2017-3973 |
First Posted: | April 6, 2018 Key Record Dates |
Last Update Posted: | November 16, 2018 |
Last Verified: | September 2018 |
Studies a U.S. FDA-regulated Drug Product: | No |
Studies a U.S. FDA-regulated Device Product: | No |