The Changes of Body Composition, Glucolipid Metabolism and Bone Metabolism in Obese Children After Weight Loss
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|ClinicalTrials.gov Identifier: NCT03490448|
Recruitment Status : Completed
First Posted : April 6, 2018
Last Update Posted : April 6, 2018
Vitamin D plays a significant role in calcium and phosphorus homeostasis for maintaining structural integrity and function of musculoskeletal system. Furthermore, recent studies have revealed that vitamin D can decrease the risk of many conditions other than skeletal disease, including autoimmune diseases, cancers, obesity and obesity-related diseases, such as type 2 diabetes and cardiovascular disease. Vitamin D may influence calcium absorption to affect obesity indirectly, regulate adipocyte differentiation and relieve the development of metabolic syndrome by mediating levels of inflammatory factors.
Another indicator of bone metabolism-osteocalcin may also be involved in energy metabolism and glucose metabolism, and undercarboxylated osteocalcin (ucOC) is the form which has physiological activity. ucOC may recombine with the receptors on the surface of pancreas β cells, adipocytes, hepatocytes and intestinal endocrine cell to regulate insulin secretion and insulin sensitivity.
Currently, the prevalence of vitamin D deficiency is a global problem in all age groups currently, even in countries with sun exposure all year around. The obesity group tend to have a higher incidence of vitamin D deficiency.Moreover, the obesity group tend to have a higher incidence of vitamin D deficiency and a lower level of serum osteocalcin.
This study observed the changes of body composition and glucolipid metabolism and bone metabolism during weight loss, and investigated the correlations among them.
|Condition or disease||Intervention/treatment||Phase|
|Obesity, Childhood Vitamin D Deficiency||Behavioral: aerobic exercise and appropriate caloric control||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||53 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Primary Purpose:||Health Services Research|
|Official Title:||The Changes of Body Composition, Glucolipid Metabolism and Bone Metabolism in Obese Children and Adolescents After Weight Loss Camp|
|Actual Study Start Date :||July 6, 2014|
|Actual Primary Completion Date :||August 16, 2014|
|Actual Study Completion Date :||August 16, 2014|
aerobic exercise and appropriate caloric control
Behavioral: aerobic exercise and appropriate caloric control
The dietary was designed on the basis of ensuring the daily energy physiological requirement, and basal metabolic rate (BMR) was calculated to formulate diet project according to Harris-Benedict formula. The diet was composed of 20% protein, 30% fat and 50% carbohydrates.In the exercise, heart rate was monitored to ensure the small-medial load aerobic exercise. All kinds of sports were conducted indoor, twice per day, 6 days per week, and lasted for 2 hours every time.
- changes of serum 25-OHD after weight loss [ Time Frame: after six-week weight loss camp ]
- changes of serum osteocalcin after weight loss [ Time Frame: after six-week weight loss camp ]
- changes of body composition after weight loss [ Time Frame: after six-week weight loss camp ]Indicators of body composition included weight, body mass index, triceps skinfold thickness and subcutaneous skinfold thickness.
- changes of glucolipid metabolism after weight loss [ Time Frame: after six-week weight loss camp ]Indicators of glucose metabolism included fasting blood glucose (FBG) and fasting insulin (FINS). Indicators of lipid metabolism included Total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL) and low density lipoprotein (LDL).
- changes of other bone metabolism indicators after weight loss [ Time Frame: after six-week weight loss camp ]Other bone metabolism indicators included parathyroid hormone (PTH), bone specific alkaline phosphatase (BALP), total propeptide of type I procollagen (T-PINP) and β-isomerized form carboxy-terminal telopeptide of type I collagen (β-CTX).
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03490448
|Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine|
|Shanghai, Shanghai, China, 200092|
|Principal Investigator:||Qingya Tang, Mater||Department of Clinical Nutrition, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine|