Apelin12 in Acne Vulgaris
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|ClinicalTrials.gov Identifier: NCT03480503|
Recruitment Status : Unknown
Verified March 2018 by Amira Abdelaziz, Assiut University.
Recruitment status was: Not yet recruiting
First Posted : March 29, 2018
Last Update Posted : March 29, 2018
Acne vulgaris is a common chronic inflammatory disease of the pilosebaceous unit which is characterized by the formation of non-inflammatory open and closed comedones and inflammatory papules, pustules, nodules and cysts.
It is a multifactorial disease that affects mostly adolescent population. Acne appears very early in puberty during the preteen years, often before menarche in girls. Because many adolescents have acne, it is difficult to predict which individuals are prone to severe cases.
The pathogenesis of acne is complex, with strong evidence supporting the involvement of follicular hyperkeratinization, hyperactivity of the sebaceous glands, colonization of Propionibacterium acnes and yeast, and inflammation. Although the importance of androgens in the pathophysiology of acne has been supported by both clinical studies and experimental data, the research evaluating adipokines are very few in patients with acne vulgaris.
|Condition or disease|
|Study Type :||Observational|
|Estimated Enrollment :||90 participants|
|Official Title:||Serum apelin12 in Acne Vulgaris|
|Estimated Study Start Date :||May 2018|
|Estimated Primary Completion Date :||October 2019|
|Estimated Study Completion Date :||December 2019|
Patients with acne vulgaris , measurement of serum apelin12 by using ELISA technique ,complete lipid profile and fasting blood glucose.
Healthy control volunteers, measurement of serum apelin12 by using ELISA technique ,complete lipid profile and fasting blood glucose.
- serum apelin12 [ Time Frame: 12 hour ]blood samples will be taken then measurement of serum apelin12 by using ELISA technique after fasting 12 hours.
- Complete lipid profile. [ Time Frame: 12hour ]blood samples will be taken and complete lipid profile will be measured after fasting 12 hours by biochemical measurement.
- Fasting blood glucose [ Time Frame: 7hours ]blood samples will be taken and fasting blood glucose level will be measured after fasting 7 hours by biochemical measurement method.
Biospecimen Retention: Samples With DNA
The venous blood sample will be taken from acne patients and control group after fasting for 10-12 hours and the following will be done:
Fasting blood glucose. Complete lipid profile. Serum level of apelin-12 will be measured using enzyme linked immunosorbent assay(ELISA) technique .
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03480503
|Contact: Doaa Abu taleb, lecturer||01001463937||Dodda_aboutaleb@yahoo.com|
|Contact: Eman Kamal, assis email@example.com|