Bariatric Surgery and Pharmacokinetics of Hydrochlorothiazide
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Changes to gastric pH, gastric emptying time, gastrointestinal transit-time or the pre-systemic metabolizing effect of enzymes secreted in the mucosa may all alter the pharmacokinetics of medicines. These factors are potentially influenced by bariatric surgery. Little is so far known about how gastric bypass and sleeve gastrectomy impacts the biological availability of medication. In this study the pharmacokinetic effects of bariatric surgery on hydrochlorothiazide are investigated.
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Layout table for eligibility information
Ages Eligible for Study:
18 Years to 70 Years (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Patients referred for bariatric surgery (gastric bypass or sleeve gastrectomy)
Preparing to undergo gastric bypass or sleeve gastrectomy in Central Norway
Being a Norwegian citizen
Having previously undergone resections in the GI-tract