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DNA Methylation and Hydroxymethylation Levels in Patients With Coronary Heart Disease

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ClinicalTrials.gov Identifier: NCT03462277
Recruitment Status : Recruiting
First Posted : March 12, 2018
Last Update Posted : November 12, 2018
Sponsor:
Information provided by (Responsible Party):
Dongying Zhang, Chongqing Medical University

Brief Summary:
The purpose of this trial is to investigate the relationship between DNA methylation and hydroxymethylation and the expression of DNMTs, TET family gene and the degree of coronary heart disease.

Condition or disease
Coronary Heart Disease

Detailed Description:
  1. To determine the levels of DNA methylation and hydroxymethylation with coronary heart disease.
  2. To investigate the relationship between DNA methylation and hydroxymethylation and the degree of coronary atherosclerosis.

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Study Type : Observational [Patient Registry]
Estimated Enrollment : 200 participants
Observational Model: Cohort
Time Perspective: Prospective
Target Follow-Up Duration: 1 Year
Official Title: DNA Methylation and Hydroxymethylation Levels in Patients With Coronary Heart Disease
Actual Study Start Date : January 1, 2018
Estimated Primary Completion Date : December 1, 2018
Estimated Study Completion Date : December 1, 2018

Resource links provided by the National Library of Medicine


Group/Cohort
Control group
Control group was defined as people with negative findings in coronary angiograms.
Coronary Heart Disease group
CHD patients was defined as at least one lesion in a coronary artery or branches in coronary angiograms.



Primary Outcome Measures :
  1. DNA Methylation and Hydroxymethylation Levels [ Time Frame: 1 month ]
    Collection of blood samples and measuring the samples by PCR and ELISA


Biospecimen Retention:   Samples With DNA
human blood samples, human aortic tissues


Information from the National Library of Medicine

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Ages Eligible for Study:   65 Years and older   (Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

Patients with Coronary Heart Disease and Patients without Coronary Heart Disease.

All patients underwent carotid ultrasound and coronary angiograms.

Criteria

Inclusion Criteria:

Male and Female. Patients older than 65 years old who are willing to participate in the study. CHD patients was defined as at least one lesion in a coronary artery or branches in coronary angiograms. Control group was defined as people with negative findings in coronary angiograms.

Exclusion Criteria:

Patients with concurrent infection or any documented inflammatory illness, such as arthritis or connective tissue diseases, or any other malignancy. Patients with a history of cardiomyopathy. Pregnant women. Severe hepatic dysfunction or End-stage renal failure. Uncontrolled hypertension.


Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03462277


Contacts
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Contact: Dongying Zhang, doctor +8613608398395 zdy.chris@qq.com

Locations
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China
The First Affiliated Hospital of Chongqing Medical University Recruiting
Chongqing, China
Contact: Dongying Zhang, doctor    +8613608398395    zdy.chris@qq.com   
Sponsors and Collaborators
Chongqing Medical University
Investigators
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Study Director: Dongying Zhang, doctor First Affiliated Hospital of Chongqing Medical University
Principal Investigator: Dan Jiang First Affiliated Hospital of Chongqing Medical University

Additional Information:

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Responsible Party: Dongying Zhang, doctor, Chongqing Medical University
ClinicalTrials.gov Identifier: NCT03462277     History of Changes
Other Study ID Numbers: 2016-39
First Posted: March 12, 2018    Key Record Dates
Last Update Posted: November 12, 2018
Last Verified: November 2018

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No

Keywords provided by Dongying Zhang, Chongqing Medical University:
methylation
hydroxymethylation
atherosclerosis
coronary heart disease

Additional relevant MeSH terms:
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Heart Diseases
Coronary Disease
Coronary Artery Disease
Myocardial Ischemia
Cardiovascular Diseases
Vascular Diseases
Arteriosclerosis
Arterial Occlusive Diseases