Right Ventricular Function During Liver Transplantation as Assessed by Transesophageal Echocardiography.
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|ClinicalTrials.gov Identifier: NCT03459924|
Recruitment Status : Active, not recruiting
First Posted : March 9, 2018
Last Update Posted : March 9, 2018
|Condition or disease|
|Liver Transplant; Complications|
Evaluation of right ventricular function (RVF) during orthotopic liver transplantation (OLT) has been extensively reported with modified pulmonary artery catheters that measure the right ventricular ejection fraction. However, quantitative analysis of RVF using transesophageal echocardiography (TEE) are scarce in this setting.
Methods: Nineteen cirrhotic patients who underwent OLT from April-2012 to April-2013 will be studied. Analysis of echocardiogram-derived parameters routinely used to evaluate ventricular function will be done. In particular, the RVF was quantitatively assessed by two parameters derived from TEE: tricuspid annular plane systolic excursion (TAPSE) and right ventricular fractional area change (RVFAC). Exclusion criteria: pulmonary hypertension, fulminant hepatitis, age less than 18 or greater than 65 years old and cardiopulmonary diseases. All echocardiographic and hemodynamic data set have been collected at 5 stages during the procedure, according to Institutional Protocol: baseline, hepatectomy, anhepatic phase, post-reperfusion, and closure.
Statistical Analysis: One-way ANOVA for repeated measurements will be used if the data have normal distribution, otherwise Friedman test will be used. P<0.05 is to be considered significant.
|Study Type :||Observational|
|Actual Enrollment :||19 participants|
|Official Title:||Intraoperative Evaluation of Right Ventricular Function During Liver Transplantation: a Quantitative Analysis Using Transesophageal Echocardiography|
|Actual Study Start Date :||February 27, 2018|
|Estimated Primary Completion Date :||January 1, 2019|
|Estimated Study Completion Date :||January 1, 2019|
- Development of new right ventricular dysfunction during liver transplantation [ Time Frame: Through study completion, after 1 year of data retrieval and analysis. ]Signs of right ventricular dysfunction as assessed by transesophageal echocardiography
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Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03459924
|Federal University of Rio de Janeiro|
|Rio De Janeiro, Brazil, 21941590|
|Study Chair:||Nubia V Figueiredo, MSc, PhD||Universidade Federal do Rio de Janeiro|