Quantitative MRI for Patients With Sickle Cell Disease Undergoing Hematopoietic Cell Transplant
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|ClinicalTrials.gov Identifier: NCT03458897|
Recruitment Status : Recruiting
First Posted : March 8, 2018
Last Update Posted : May 2, 2019
|Condition or disease||Intervention/treatment||Phase|
|Sickle Cell Disease||Diagnostic Test: serial functional magnetic resonance imaging (MRI)||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||10 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Official Title:||Quantitative MRI for Patients With Sickle Cell Disease Undergoing Hematopoietic Cell Transplant|
|Actual Study Start Date :||May 3, 2018|
|Estimated Primary Completion Date :||August 2022|
|Estimated Study Completion Date :||August 2023|
Experimental: MRI arm
Subjects with sickle cell disease undergoing bone marrow transplantation will undergo serial functional MRI (up to 4 scans).
Diagnostic Test: serial functional magnetic resonance imaging (MRI)
All subjects with sickle cell disease undergoing bone marrow transplantation will undergo up to 4 functional MRI scans.
- Feasibility [ Time Frame: 110 days post transplant ]Feasibility will be measured by the number of subjects who undergo at least 2 of 4 scheduled functional MRI's
- MRI and hemoglobin S. [ Time Frame: 1 year post transplant ]Correlation between functional MRI result and hemoglobin S level.
- MRI and neutrophil engraftment [ Time Frame: 1 year post transplant ]Correlation between functional MRI result and time to neutrophil engraftment
- MRI and chimerism [ Time Frame: 1 year post transplant ]Correlation between functional MRI result and time to donor/ recipient chimerism
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03458897
|Contact: Connie Varnerfirstname.lastname@example.org|
|United States, Michigan|
|University of Michigan||Recruiting|
|Ann Arbor, Michigan, United States, 48109|
|Contact: Connie Varner email@example.com|
|Principal Investigator: Ghada Abusin, MBBS|
|Principal Investigator:||Ghada Abusin, MBBS MS||University of Michigan|