Comparison of HFNC With NIV in Weaning COPD
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|ClinicalTrials.gov Identifier: NCT03458364|
Recruitment Status : Recruiting
First Posted : March 8, 2018
Last Update Posted : March 8, 2018
|Condition or disease||Intervention/treatment||Phase|
|Chronic Obstructive Pulmonary Disease With (Acute) Exacerbation||Device: High flow nasal cannula Device: Noninvasive ventilation||Not Applicable|
High flow nasal cannula (HFNC) provides high concentration oxygen in a high flow, which exceeds patient's inspiratory flow demand, to improve oxygenation. In a recent meta-analysis of seven trials with 1771 patients, HFNC was shown to improve oxygenation and avoid intubation in patients with severe hypoxemia. The high velocity of the gas can rinse the dead space of the upper airway and reduce CO2 rebreathing, reduce COPD patients' work of breathing and improve the dynamic compliance of respiratory system.
Thus, we proposed a randomized controlled trial to investigate the value of high flow nasal cannula in weaning AECOPD patients from invasive ventilation, with comparison of noninvasive ventilation.
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||40 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||None (Open Label)|
|Official Title:||Comparison of High Flow Nasal Cannula With Noninvasive Ventilation in Facilitating Weaning Chronic Obstructive Pulmonary Disease From Invasive Ventilation: a Prospective Randomized Controlled Study|
|Actual Study Start Date :||June 26, 2017|
|Estimated Primary Completion Date :||April 2018|
|Estimated Study Completion Date :||June 2018|
Experimental: High flow nasal cannula
High flow nasal cannula (HFNC) is a type of oxygen device, which provides high concentration oxygen in a high flow, which exceeds patient's inspiratory flow demand, to improve oxygenation.
Device: High flow nasal cannula
High-flow nasal cannula (HFNC) oxygen therapy is a recent technique delivering a high flow of heated and humidified gas. HFNC is simpler to use and apply than noninvasive ventilation (NIV) and appears to be a good alternative treatment for hypoxemic acute respiratory failure (ARF). HFNC is better tolerated than NIV, delivers high fraction of inspired oxygen (FiO2), generates a low level of positive pressure and provides washout of dead space in the upper airways, thereby improving mechanical pulmonary properties and unloading inspiratory muscles during ARF.
Other Name: High flow high humidity nasal cannula
Active Comparator: Noninvasive ventilation
Non-invasive ventilation (NIV) refers to the provision of ventilatory support through the patient's upper airway using a mask. This technique is distinguished from those which bypass the upper airway with a tracheal tube, laryngeal mask, or tracheostomy and are therefore considered invasive.
Device: Noninvasive ventilation
Non-invasive ventilation (NIV) is the use of airway support administered through a face (nasal) mask instead of an endotracheal tube. Inhaled gases are given with positive end-expiratory pressure often with pressure support or with assist control ventilation at a set tidal volume and rate. Numerous studies have shown this technique to be as effective as, and better tolerated than, intubation and mechanical ventilation in patients with exacerbations of COPD
Other Name: Noninvasive positive pressure ventilation; Noninvasive mechanical ventilation
- Weaning failure [ Time Frame: 48 Hours ]Reintubation within 48 hours after extubation
- ICU stay [ Time Frame: 3-7 days ]days of staying in ICU
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03458364
|Contact: Guoqiang Jing, BSemail@example.com|
|Contact: Jie Li, MS||Jie_Li@rush.edu|
|Binzhou Medical University Hospital||Recruiting|
|Yantai, Shandong, China, 264003|
|Contact: Guoqing Jing 86-0-13954319467 firstname.lastname@example.org|
|Study Chair:||Xiaozhi Wang, MD||Binzhou Medical University|