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The Use of Perfusion CT Derived Parameters as Early Acute Pancreatitis Severity Biomarker Compared to Clinico Biological Score (K-PA)

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ClinicalTrials.gov Identifier: NCT03456557
Recruitment Status : Completed
First Posted : March 7, 2018
Last Update Posted : April 14, 2020
Sponsor:
Information provided by (Responsible Party):
Poitiers University Hospital

Brief Summary:

The investigators to establish whether early microvascular permeability parameter evaluated by perfusion-CT could be good biomarkers for severity in acute pancreatitis.

Therefore the investigators want to compare 48 hours-clinico-biological systemic inflammatory response syndrome score to initial microvascular permeability parameters ( ktrans - capillary membrane permeability factor- and pancreatic blood flow ) calculated by OLEA software using inclusion perfusion CT.


Condition or disease Intervention/treatment Phase
Acute Pancreatitis Radiation: Perfusion computed tomography. Not Applicable

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 15 participants
Allocation: N/A
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Diagnostic
Official Title: The Use of Perfusion CT Derived Parameters as Early Acute Pancreatitis Severity Biomarker Compared to Clinico Biological Score
Actual Study Start Date : March 7, 2018
Actual Primary Completion Date : December 9, 2018
Actual Study Completion Date : December 9, 2018

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Pancreatitis

Arm Intervention/treatment
Experimental: Computed tomography. Radiation: Perfusion computed tomography.
Using specific post treatment imaging software ( Olea® ) we will calculatell permeability parameters : the pancreatic blood flow and the k-trans, capillary membrane permeability factor.




Primary Outcome Measures :
  1. Relation between CT perfusion calculated k-trans and clinicobiological SIRS score in early phase of acute pancreatitis. [ Time Frame: admission day ]


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Ages Eligible for Study:   18 Years to 100 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Patient with acute pancreatitis (based on the Atlanta definition).

Exclusion Criteria:

  • Patient under 18 yearras old
  • Contraindication of injection of iodinated contrast medium
  • Pregnancy

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03456557


Locations
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France
Chu de Poitiers
Poitiers, France, 86021
Sponsors and Collaborators
Poitiers University Hospital
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Responsible Party: Poitiers University Hospital
ClinicalTrials.gov Identifier: NCT03456557    
Other Study ID Numbers: K-PA Study
First Posted: March 7, 2018    Key Record Dates
Last Update Posted: April 14, 2020
Last Verified: April 2020

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Additional relevant MeSH terms:
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Pancreatitis
Pancreatic Diseases
Digestive System Diseases